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Wyświetlanie 1-15 z 16
Tytuł:
Artificial heart: Hydrophobic coating to make it more natural
Autorzy:
Ziętek, P. A.
Butruk, B.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/115759.pdf
Data publikacji:
2011
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
hydrophobic coatings
polyurethane vascular devices
blood coagulation
Opis:
Polyurethanes are biocompatible materials commonly used in medical applications, mainly as coatings for vascular grafts and artificial hearts. There are many methods to increase hemocompatibility of polyurethane surfaces. Presented study was undertaken to obtain hydrophobic polyurethane coatings by silicone and perfl uorocarbohydrate modification. The aim of this work was to obtain smooth and homogenous coatings, as porous materials are likely to cause blood coagulation. Surface analysis (IR spectroscopy and scanning acoustic microscopy) revealed that the applied method allows to modify polyurethane surface successfully. An increase in material hydrophobicity was confirmed contact angle measurement.
Źródło:
Challenges of Modern Technology; 2011, 2, 3; 15-19
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Some remarks on the convergence in measure and on a dominated sequence of operators measurable with respect to a semifinite von Neumann algebra
Autorzy:
Ciach, Leszek Jan
Powiązania:
https://bibliotekanauki.pl/articles/726020.pdf
Data publikacji:
1988
Wydawca:
Polska Akademia Nauk. Instytut Matematyczny PAN
Źródło:
Colloquium Mathematicum; 1988, 55, 1; 109-121
0010-1354
Pojawia się w:
Colloquium Mathematicum
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The factor VIII protein and its function
Autorzy:
Mazurkiewicz-Pisarek, Anna
Płucienniczak, Grażyna
Ciach, Tomasz
Płucienniczak, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1038835.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Factor VIII (FVIII)
molecular structure
function
hemophilia A
bleeding disorders
Opis:
Factor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. Human factor VIII is a single chain of about 300 kDa consisting of domains described as A1-A2-B-A3-C1-C2. The protein undergoes processing prior to secretion into blood resulting in a heavy chain of 200 kDa (A1-A2-B) and a light chain of 80 kDa (A3-C1-C2) linked by metal ions. The role of factor VIII is to increase the catalytic efficiency of factor IXa in the activation of factor X. Variants of these factors lead frequently also to severe bleeding disorders.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 11-16
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cell outer membrane mimetic surface as a material with improved hemocompatibility
Autorzy:
Trzaskowski, M.
Butruk, B.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/115627.pdf
Data publikacji:
2011
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
phosphatidylcholine
polyurethane
cell outer membrane mimetic surface
artificial heart
Opis:
The phenomenon of blood coagulation on the surfaces of implantable devices such as artifi cial blood vessels, valves or hearts is the major problem that has to be taken into consideration during the construction of such devices. Since the main factor that has an infl uence on clotting of blood is the surface of the material the device is made of, numerous attempts has already been undertaken to modify surfaces of existing materials in order to provide necessary protection against clot formation, very often by coating the materials with bio-active substances. The aim of presented study was to create a coating of phosphatidylcholine that would mimic natural cell outer membrane on the surface of polyurethane — a material already in use in construction of cardiovascular implants. The obtained coated materials have been evaluated with the use of FT-IR/ATR spectroscopy. The change in contact angle of modifi ed material was also investigated. Finally in vitro cytotoxicity tests were performed in order to examine biocompatibility of obtained material.
Źródło:
Challenges of Modern Technology; 2011, 2, 4; 7-10
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of a Fibrous Electrostatic Filter for Treatment of Diesel Exhaust
Autorzy:
Ciach, T.
Sosnowski, T. R.
Powiązania:
https://bibliotekanauki.pl/articles/89862.pdf
Data publikacji:
2000
Wydawca:
Centralny Instytut Ochrony Pracy
Tematy:
diesel exhaust filtration
soot particles
exhaust
spaliny
spaliny silnika Diesla
filtracja spalin
sadza
Opis:
The paper presents results of investigations of a novel method for diesel exhaust filtration in a fibrous filter supplemented by the external electrostatic field (FEF), which may be used to eliminate the occupational hazard near sources of diesel emission. The reported research follows the preliminary basic study of soot removal in such systems (Ciach, Sosnowski, & Podgorski, 1995), and is focused on the construction and testing of a prototype technical-scale FEF device. The results suggest a strong relation between applied voltage and filtration efficiency of the system and demonstrate the influence of aerosol precharging on the efficiency, which can be more than 95%.
Źródło:
International Journal of Occupational Safety and Ergonomics; 2000, 6, 3; 321-333
1080-3548
Pojawia się w:
International Journal of Occupational Safety and Ergonomics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carboxymethyl Cellulose Oxidation to Form Aldehyde Group
Autorzy:
Kulikowska, A.
Wasiak, I.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/115877.pdf
Data publikacji:
2013
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
oxidation
carboxymethylcellulose
sodium periodate
hydrogen peroxide
iron tetrasulfophthalocyanine
utlenianie
karboksymetyloceluloza
nadjodan sodu
nadtlenek wodoru
żelazo tetrasulfophthalocyanine
Opis:
Oxidation of carboxymethyl cellulose (CMC) is a method of its modification, which allows to improve the functionality of this compound by increasing its reactivity. Presented work describes two methods of oxidation of carboxymethyl cellulose. The first is the conversion of CMC to its dialdehyde derivatives (DCMC) by sodium periodate. In the second method, hydrogen peroxide in the presence of iron tetrasulfophthalocyanine (FePcS) as catalyst was applied. Oxidation degree of CMC in different process parameters and time intervals was estimated using hydroxylamine hydrochloride. Modified CMC will be used in nanoparticles preparation in medical diagnostics.
Źródło:
Challenges of Modern Technology; 2013, 4, 2; 11-18
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of hydroxyapatite in a continuous reactor : a review
Autorzy:
Latocha, J.
Wojasiński, M.
Sobieszuk, P.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/185159.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
hydroxyapatite
synthesis in continuous reactor
continuous precipitation
microparticles
nanoparticles
hydroksyapatyt
synteza w reaktorze ciągłym
ciągłe opady
mikrocząsteczki
nanocząsteczki
Opis:
Because of excellent properties, similar to natural bone minerals, and variety of possible biomedical applications, hydroxyapatite (HAp) is a valuable compound among the calcium phosphate salts. A number of synthesis routes for producing HAp powders have been reported. Despite this fact, it is important to develop new methods providing precise control over the reaction and having potential to scale-up. The main motivation for the current paper is a view of continuous synthesis methods toward medical application of produced hydroxyapatite, especially in the form of nanoparticles.
Źródło:
Chemical and Process Engineering; 2018, 39, 3; 281--293
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of carboxymethylcellulose nanoparticles using various coiling agents
Synteza nanocząstek karboksymetylocelulozowych z wykorzystaniem różnych czynników zwijających
Autorzy:
Kulikowska, A.
Wasiak, I.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/2072916.pdf
Data publikacji:
2014
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
carboxymethylcellulose
benzylamine
hexylamine
octylamine
karboksymetyloceluloza
benzyloamina
heksyloamina
octyloamina
Opis:
Polysaccharide-based nanoparticles (NPs), due to their outstanding properties, attract much attention in the field of drug delivery systems. Presented work describes a method of carboxymethyl cellulose NPs synthesis which can serve as anticancer drugs carriers. The main goal of this research was to investigate the influence of type and amount of aliphatic amine and different carboxymethyl cellulose oxidation degree on the resulting NPs size.
Nanocząstki polisacharydowe ze względu na swoje unikalne właściwości cieszą się dużym zainteresowaniem w systemach podawania leków. Prezentowana praca opisuje metodę syntezy nanocząstek karboksymetylocelulozowych, które mogą pełnić rolę nośnika leków przeciwnowotworowych. Celem wykonanych badań było zbadanie wpływu typu i ilości użytej aminy alifatycznej oraz różnych stopni utlenienia karboksymetylocelulozy na rozmiar powstających nanocząstek.
Źródło:
Inżynieria i Aparatura Chemiczna; 2014, 4; 268--269
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of polylactide modification with β-TCP and lecithin on the properties of the material as a substrate for osteoblasts
Autorzy:
Olkowski, R.
Stefanek, A.
Kaszczewski, P.
Ciach, T.
Lewandowska-Szumieł, M.
Kalaszczyńska, I.
Powiązania:
https://bibliotekanauki.pl/articles/285423.pdf
Data publikacji:
2015
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polylactide
lecithin
osteoblasts
scaffold
bone tissue engineering
Opis:
Polylactide (PLLA) containing β-TCP is biodegradable composite and an attractive biomaterial for bone tissue engineering, however, hydrophobicity of PLLA based composites is major limitation for their use as scaffolds for cell culture. In our study lecithin was used to improve hydrophilicity and cytocompatibility of PLLA/ β-TCP composite. Thin films of PLLA, PLLA/ β-TCP and PLLA/β-TCP/lecithin were manufactured by solvent-casting technique. Comparative analysis of all types of films was performed. Addition of β-TCP did not change hydrophilicity of PLLA. The hydrophilicity of PLLA/β-TCP/lecithin increased in comparison to PLLA and PLLA/β-TCP. Degradation of PLLA/β-TCP composite surpassed the degradation of PLLA while addition of lecithin diminished the degradation of composite. The cytocompatibility of composites were studied in 7 day long in vitro assay. Human bone derived cells were seeded on all tested surfaces. Cell viability was estimated by Live/Dead fluorescent staining and Alamar Blue test. Surprisingly, although lecithin addition improved hydrophilicity of the PLLA-based composite, adhesion and proliferation of human bone derived cells were markedly hampered on PLLA/β-TCP/lecithin in comparison to PLLA and PLLA/β-TCP. Despite positive effect we found of lecithin addition on hydrophilicity and stability of PLLA-based composite, its effect on cell attachment and proliferation is negative. Hence, incorporation of lecithin did not improve properties of PLLA/β-TCP/lecithin composite intended for bone tissue regeneration.
Źródło:
Engineering of Biomaterials; 2015, 18, 131; 8-11
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of the coating process parameters on the quality of PUR/PVP hydrogel coatings for PVC medical devices
Autorzy:
Paradowska, A.
Kaźmierska, K.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/779563.pdf
Data publikacji:
2010
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
poliwinylopirolidon
powłoka hydrożelowa
metoda zanurzeniowa
poli(chlorek winylu)
Hydrogel coatings
dip-coating
poly(vinyl chloride)
polyvinylpyrrolidone
Opis:
To decrease friction factor and enhance the biocompatibility of medical devices manufactured from poly(vinyl chloride), PVC, the surface modification with wear resistant polyurethane/polyvinylpyrrolidone (PUR/PVP) hydrogel coating can be applied. In the present work substrates were dip-coated with PVP and PUR solutions and thermally cured. The variable process parameters were: solvent system; concentration of polymers (1, 2 or 3% w/v); coating baths temperature (22, 38 and 55°C); drying temperature (32, 50 and 67°C); length of break between process steps (5, 30 and 90 s); and solutions storage time (up to 72 hrs). The quality of coatings was determined by friction coefficients against porcine aorta, weights of the deposited layer and the swelling capacity. The solvent system and polymers concentration were crucial factors. The increased temperature of coating solutions caused increased deposition but decreased durability. The most lubricious samples were dried in 50oC. Coatings from the solutions prepared 24h prior to use had better properties than those from fresh solutions.
Źródło:
Polish Journal of Chemical Technology; 2010, 12, 2; 38-45
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effectiveness of e-government development in poland in 2004-2013
Autorzy:
Kaczorowska, A.
Ciach, K.
Powiązania:
https://bibliotekanauki.pl/articles/95119.pdf
Data publikacji:
2013
Wydawca:
Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
Tematy:
information society
informatization of the public administration
IT projects
e-government
government e-services
e-Government Benchmark Measurement
społeczeństwo informacyjne
informatyzacja administracji publicznej
projekty IT
e-administracja
Opis:
Poland more than 10 years later than the other European Union (EU) states acted towards informatizaton of public administration, thanks to which it was possible to share public services with individuals and companies by electronic means. This article will analyze the assessment of our country in the aspect of full online availability and maturity of 20 public services in all editions of the study entitled eGovernment Benchmark Measurement. It’s a comparative study, in which Poland appeared as a new member of EU in 2004. In the period from 2008 to the 2010, Poland has made a significant progress in most indicators of information society (SPI). However, in 2013 our country is still closer to the end than to the middle of the chain of e-government effectiveness in the EU.
Źródło:
Information Systems in Management; 2013, 2, 4; 274-288
2084-5537
2544-1728
Pojawia się w:
Information Systems in Management
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of the gene encoding blood coagulation factor VIII without domain B in E. coli bacterial expression system
Autorzy:
Mazurkiewicz-Pisarek, Anna
Mazurkiewicz, Alina
Mikiewicz, Diana
Baran, Piotr
Ciach, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/16706242.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
factor VIII
hemophilia type A
recombinant coagulation factor VIII
prokaryotic expression system
E. coli
recombinant protein production system
Opis:
In this article, we have demonstrated the feasibility of generating an active form of recombinant blood coagulation factor VIII using an E. coli bacterial expression system as a potential treatment for hemophilia type A. Factor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. So far, all available recombinant FVIII formulations have been produced using eukaryotic expression systems. Mammalian cells can produce catalytically active proteins with all the necessary posttranslational modifications. However, cultivating such cells is time-consuming and highly expensive, and the amount of the obtained product is usually low. In contrast to eukaryotic cells, bacterial culture is inexpensive and allows the acquisition of large quantities of recombinant proteins in a short time. With this study, we aimed to obtain recombinant blood coagulation factor VIII using the E. coli bacterial expression system, a method not previously explored for this purpose. Our research encompasses the synthesis of blood coagulation factor VIII and its expression in a prokaryotic system. To achieve this, we constructed a prokaryotic expression vector containing a synthetic factor VIII gene, which was then used for the transformation of an E. coli bacterial strain. The protein expression was confirmed by mass spectrometry, and we assessed the stability of the gene construct while determining the optimal growth conditions. The production of blood coagulation factor VIII by the E. coli bacterial strain was carried out on a quarter-technical scale. We established the conditions for isolation, denaturation, and renaturation of the protein, and subsequently confirmed the activity of FVIII.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2023, 104, 3; 247-262
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Electrospun poly-L-lactic acid/nanohydroxyapatite nanofibrous composite as a potential bone tissue replacement material
Elektroprzędzony nanowłóknisty kompozyt poli-L-kwasu mlekowego/hydroksyapatytu jako potencjalny materiał zastępujący tkankę kostną
Autorzy:
Wojasiński, M.
Bożyk, J
Wasiak, I.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/2072951.pdf
Data publikacji:
2014
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
substytut kości
nanoHAP
nanowłókna
elektroprzędzenie
bone replacement material
nanofibers
electrospinning
Opis:
W prezentowanych badaniach użyto nanocząstek hydroksyapatytu (nanoHAP) do przygotowania nanowłóknistego kompozytu poli-L-kwasu mlekowego/hydroksyapatytu za pomocą elektroprzędzenia. Zbadano średni rozmiar i strukturę nanoHAP, średnią średnicę nanowłókien i ich strukturę. Dodatkowo, zbadano skład chemiczny wszystkich przygotowanych materiałów. Wytworzono nanowłókna PLLA/nanoHAP o średniej średnicy włókna 202 ± 6 nm z jednorodnie rozproszonymi cząstkami nanoHAP w strukturze włóknistej.
In present study, nanoparticles of hydroxyapatite (nanoHAP) were used to prepare nanofibrous composite of poly-L-lactic acid/hydroxyapatite by electrospinning. An average size and structure of nanoHAP, nanofibers average diameter and structure of nanofibrous materials were investigated. Additionally, the chemical composition of all materials was investigated. Nanofibers of PLLA/nanoHAP having the average diameter of 202 ± 6 nm with uniformly dispersed nanoHAP in the fibrous structure were produced.
Źródło:
Inżynieria i Aparatura Chemiczna; 2014, 4; 322--323
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vitro immune evaluation of adenoviral vector-based platform for infectious diseases
Autorzy:
Baran, J.
Kuryk, L.
Szczepińska, T.
Łaźniewski, M.
Garofalo, M.
Mazurkiewicz-Pisarek, A.
Mikiewicz, D.
Mazurkiewicz, A.
Trzaskowski, M.
Wieczorek, M.
Pancer, K.
Hallmann, E.
Brydak, L.
Plewczynski, D.
Ciach, T.
Mierzejewska, J.
Staniszewska, M.
Powiązania:
https://bibliotekanauki.pl/articles/28825288.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2023, 104, 4; 403-419
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 16

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