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Wyświetlanie 1-5 z 5
Tytuł:
Effect of aging and oxidative/genotoxic stress on poly(ADP-ribose) polymerase-1 activity in rat brain
Autorzy:
Strosznajder, Robert
Jesko, Henryk
Adamczyk, Agata
Powiązania:
https://bibliotekanauki.pl/articles/1041342.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
aging
poly(ADP-ribosyl)ation
brain
p53 protein
PARP-1
genotoxic stress
oxidative stress
Opis:
Poly(ADP-ribose) polymerase-1 (PARP-1, EC 2.4.2.30), a DNA-bound enzyme, plays a key role in genome stability, but after overactivation can also be responsible for cell death. The aim of the present study was to investigate PARP-1 activity in the hippocampus, brain cortex, striatum and cerebellum in adult (4 months) and aged (24 months) specific pathogen free Wistar rats and to correlate it with PARP-1 protein level and p53 expression. Moreover, the response of PARP-1 in adult and aged hippocampus to oxidative/genotoxic stress was evaluated. Our data indicated a statistically significant enhancement of PARP-1 activity in aged hippocampus and cerebral cortex comparing to adults without statistically significant changes in PARP-1 protein level. The expression of p53 mRNA was elevated in all aged brain parts with the exception of the cerebral cortex. Our data suggest that enhancement of PARP-1 activity and p53 expression in aged brain may indicate higher DNA damage. Our data also indicate that during excessive oxidative/genotoxic stress there is no response of PARP-1 activity in aged hippocampus in contrast to a significant enhancement of PARP-1 activity in adults which may have important consequences for the physiology and pathology of the brain.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 909-914
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relief as an important factor in determining priority landscapes: a case study on Polish landscape parks
Autorzy:
Wałdykowski, Piotr
Adamczyk, Joanna
Ciszewska, Agata
Powiązania:
https://bibliotekanauki.pl/articles/947094.pdf
Data publikacji:
2020
Wydawca:
Uniwersytet Warszawski. Wydział Geografii i Studiów Regionalnych
Tematy:
Relief typology
landscape conservation
applied geomorphology
landscape audit
Opis:
The practical problems of implementing the Regulation on Landscape Audits (European Landscape Convention, ELC) in Poland are discussed through the topic of landscape relief, on an example of landscape classification of three of Poland’s landscape parks. In the existing landscape typologies, various criteria are proposed, in which relief is usually considered to be one of the leading components. The study was carried out for the purposes of the Landscape Parks Conservation Plans, based on a comparison of the method under the Principles of Landscape Audits and the authors’ method. The results indicate that the landscape types set out in the regulation insufficiently take relief into account, leading to omitting the local specific nature of the terrain. The essential attributes of the terrain in the analysed parks are the morphometry of relief and its genesis. Relief helps to determine the landscape types that are more related to the terrain.
Źródło:
Miscellanea Geographica. Regional Studies on Development; 2020, 24, 1; 42-50
0867-6046
2084-6118
Pojawia się w:
Miscellanea Geographica. Regional Studies on Development
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nasal glial heterotopia – Clinical manifestation in 2.5 month-old boy
Autorzy:
Kałużna-Młynarczyk, Agata
Pucher, Beata
Sroczyński, Jakub
Kotowski, Michał
Adamczyk, Paulina
Szydłowski, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/1399445.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
congenital defec
midline nasal tumor
nasal glial heterotopia
nasal glioma
rhinology
Opis:
Nasal glial heterotopia is a rare congenital defect that is formed during embryonic development. This lesion is a part of a larger group of diseases, congenital midline nasal tumors, that occur with a frequency of one per 20,000-40,000 live births. Histologically, nasal glial heterotopia is a concentration of glial tissue which exhibits no malignant potential. We can differentiate three basic types of the disease based on the location of the lesion: 60% of nasal gliomas are extra nasal, 30% are intranasal and only 10% combine extra- and intranasal components. Because of its rare occurrence, correct diagnosis is quite difficult. We present a case of a 2.5-month-old male who was admitted to the Department of Pediatric Otolaryngology for the diagnosis and treatment of a tumor deforming the bridge of his nose. Initial differential diagnosis included encephalocele, glial heterotopia (nasal glioma), angioma, nasal dorsal cyst, rhabdomyosarcoma, lacrimal duct cysts. We performed endoscopic examination, radiological imaging (CT, MRI) and histological assessment of the lesion. The patient was diagnosed with nasal glial heterotopia (extra-and intranasal) based on diagnostic studies and clinical manifestation. The resection of the lesion was performed by means of dual access, external and endoscopic. The results of surgical treatment are satisfactory, control endoscopy showed no presence of residual tumor.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2019, 8, 2; 43-48
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acute mastoiditis, a severe complication of acute otitis media in children – prevalence, diagnosis and treatment
Autorzy:
Kałużna-Młynarczyk, Agata
Pucher, Beata
Nurczyk, Nel
Adamczyk, Paulina
Prauzińska, Magdalena
Kotowski, Michał
Szydłowski, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/551997.pdf
Data publikacji:
2018
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
mastoiditis
otitis media
child
ear diseases.
Źródło:
Family Medicine & Primary Care Review; 2018, 3; 227-231
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevalence of allergy in children with adenoid hypertrophy and otitis media with effusion admitted to the Department of Pediatric Otolaryngology in Poznan
Autorzy:
Adamczyk, Paulina
Pucher, Beata
Prauzińska, Magdalena
Kałuzna-Młynarczyk, Agata
Kotowski, Michał
Szydłowski, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/552782.pdf
Data publikacji:
2018
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
hypersensitivity, adenoids, otitis media with effusion.
Źródło:
Family Medicine & Primary Care Review; 2018, 3; 205-209
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-5 z 5

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