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Wyświetlanie 1-15 z 752
Tytuł:
Interleukin 18 (IL-18) as a target for immune intervention
Autorzy:
Wawrocki, Sebastian
Druszczynska, Magdalena
Kowalewicz-Kulbat, Magdalena
Rudnicka, Wieslawa
Powiązania:
https://bibliotekanauki.pl/articles/1038841.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
interleukin-18 (IL-18)
IL-18 receptor
IL-18 binding protein
Opis:
Interleukin 18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and acquired immune response. In the milieu of IL-12 or IL-15, IL-18 is a potent inducer of IFN-gamma in natural killer (NK) cells and CD4 T helper (Th) 1 lymphocytes. However, IL-18 also modulates Th2 and Th17 cell responses, as well as the activity of CD8 cytotoxic cells and neutrophils, in a host microenvironment-dependent manner. It is produced by various hematopoietic and nonhematopoietic cells, including dendritic cells and macrophages. In an organism, bioactivity of the cytokine depends on the intensity of IL-18 production, the level of its natural inhibitory protein - IL-18BP (IL-18 binding protein) and the surface expression of IL-18 receptors (IL-18R) on the responding cells. This review summarizes the biology of the IL-18/IL-18BP/IL-18R system and its role in the host defense against infections. The prospects for IL-18 application in immunotherapeutic or prophylactic interventions in infectious and non-infectious diseases are discussed.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 59-63
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enriched water-H2 18 O purification to be used in routine 18FDG production
Autorzy:
Al Rayyes, A. H.
Powiązania:
https://bibliotekanauki.pl/articles/148761.pdf
Data publikacji:
2010
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
H2 18 O
radiopharmaceuticals
purification
18FDG
Opis:
18O-water obtained from an 2-deoxy-2-[18F]-fluoro-D-glucose (18FDG, Synthera) synthesis unit is used for purification. The purification process consists of ultraviolet (UV) irradiation followed by a distillation in a preevacuated system. After purification, the loss of enriched water was about only 5 per cent. Organic compounds, radioisotopes, trace metals and gases are eliminated efficiently. Results show that there is no significant difference in the production yield of 2-deoxy-2-[18F]-fluoro-D-glucose ([18F]FDG) whether using purified enriched water by the proposed method of purification or using the new enriched water. This method offers the necessary precaution from contamination by tritium during the purification process. The obtained 18FDG or Na-18F using the purified 18O-water is of tritium free.
Źródło:
Nukleonika; 2010, 55, 3; 401-405
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Strategia radzenia sobie z krzywdzicielem – polska walidacja kwestionariusza TIRM-18
Strategies of Coping with Transgressor - Polish Validation of TIRM-18 Questionnaire
Autorzy:
Kossakowska, Marlena M.
Powiązania:
https://bibliotekanauki.pl/articles/494948.pdf
Data publikacji:
2017-11-30
Wydawca:
Towarzystwo Naukowe Franciszka Salezego
Tematy:
przebaczenie
TIRM-18
życzliwość
odwet
unikanie
psychologia pozytywna
Forgiveness
TRIM-18
benevolence
revenge
avoidance
positive psychology
Opis:
Celem artykułu jest przedstawienie wyników polskiej walidacji kwestionariusza mierzącego strategie radzenia sobie z krzywdzicielem, które odpowiedzialne są za zjawisko przebaczania (TRIM-18; Transgression – Related Interpersonal Motivations; McCullough, Root and Cohen 2006). Artykuł zawiera opis procedury dotyczącej tłumaczenia z języka angielskiego na polski, wyniki analizy czynnikowej, analizy dyskryminacyjnej oraz trafności zewnętrznej. W poniższych badaniach wzięło udział 530 osób w wieku od 18 do 84 lat (345 kobiet i 185 mężczyzn). Do oceny trafności teoretycznej testu użyto jedenastu kwestionariuszy. Badanie potwierdza, że struktura polskiej wersji kwestionariusza TRIM-18 jest zgodna ze strukturą wersji anglojęzycznej. Kwestionariusz TRIM-18 w wersji polskiej okazał się jest również bardzo rzetelnym narzędziem. Może być z powodzeniem stosowany w warunkach polskich.
The aim of this paper is to present the results of Polish validation of Transgression – Related Interpersonal Motivations questionnaire (TRIM-18) by McCullough, Root, and Cohen (2006) which measures the phenomena of forgiveness. The article contains a description of the procedure of Polish translation, the results of the test reliability, discriminant and confirmatory validity. The study was conducted among 530 participants aged between 18 and 84 (345 females and 185 males). Eleven questionnaires were used for assessing the validity of the measurement. This study confirms that the structure of Polish TRIM-18 is relevant to the English language version. Polish TRIM-18 is also a very reliable tool. It can be successfully used in Polish conditions.
Źródło:
Seminare. Poszukiwania naukowe; 2017, 38, 4; 69-82
1232-8766
Pojawia się w:
Seminare. Poszukiwania naukowe
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
What Was a Relevant Translation in the 18th Century?
Autorzy:
Vasileanu, Monica
Powiązania:
https://bibliotekanauki.pl/articles/620940.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
18th century
cognitive effects
intertextuality
processing effort
relevance theory
translation
Opis:
The paper applies RT to analyse an 18th century translation of a Latin text by the preeminent Romanian scholar Demetrius Cantemir. The translation diverges significantly from the original and was met with harsh criticism. Using the conceptual toolkit of RT, I argue that the differences between the original and its English translation were motivated by the translator’s desire to yield the same cognitive effect without putting the audience to unnecessary processing effort. Both effects and effort need to be evaluated by taking into account the respective cognitive environments of the source-text and the target-text audiences. The intertextual dimension of the text under scrutiny adds to the difficulty of communicating the same message in different languages and cultures.
Źródło:
Research in Language; 2017, 15, 1; 79-96
1731-7533
Pojawia się w:
Research in Language
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Graphic layout of Polish 18th-century popular science periodicals
Autorzy:
Kamisińska, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/421918.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Polish press in the 18th century
popular science periodicals of the late 18th century
layout and graphic design
grafika prasowa XVIII wieku
polskie czasopisma popularnonaukowe XVIII wieku
Opis:
This article presents the results of a study of the graphic layout of twelve Polish popular science periodicals published in Warsaw and Cracow in the 18th century. The study compares the characteristic features of their layout and graphic design, identifies their European models, traces the sources of their texts and graphics (figures), and considers their use of various typefaces and special decorative elements to make the scientific content easier to grasp and understand.
Źródło:
Rocznik Historii Prasy Polskiej; 2016, 19, 3
1509-1074
Pojawia się w:
Rocznik Historii Prasy Polskiej
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rapid production of 18F fluoride from 2-fluoroaniline via the 19F(n,2n)18F reaction using 14 MeV neutrons
Autorzy:
Mikołajczak, R.
Staniszewska, J.
Mikołajewski, S.
Rurarz, E.
Powiązania:
https://bibliotekanauki.pl/articles/147126.pdf
Data publikacji:
2002
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
chemical and production yields
fluorine-18
radiochemical separation
(n,2n) reaction cross section
Opis:
No carrier-added 18F fluoride was produced via the 19F(n,2n)18F reaction by 14 MeV neutron irradiation of 2-fluoroaniline and subsequent extraction of the produced 18F fluoride ion with water. The fluoride was then purified by liquid chromatography on a Chromabond-NO2 column. The time required for all chemical procedures was about 1 h. The average chemical separation yield was about 70%. The 18F activity obtained after 3 hours of irradiation at a flux rate of 108 n cm-2s-1 after a necessary 20-min delay was equal to several kBq per gram of fluorine in a 2-fluoroaniline sample, in accordance with the theoretically expected value. Improvement of the 18F production yield can be achieved by increasing neutron fluxes. Neutron generators with 14 MeV neutron fluxes of the order of 1010 n cm-2s-1 can produce tens MBq of 18F, sufficient for whole-day work in biomedical applications. Our results show that 14 MeV neutron irradiation of 2-fluoroaniline is a low cost alternative for the production of this nuclide in the countries which do not posses either cyclotrons or electron linear accelerator facilities.
Źródło:
Nukleonika; 2002, 47, 1; 13-18
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
“The Judgment of Hercules”. Shaftesbury at the Crossroads of Art Theory
„Sąd Herkulesa”. Shaftesbury na rozstajnych drogach historii sztuki
Autorzy:
Jaźwierski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/2082092.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
art theory
aesthetic theory
literary theory
18th Century British aesthetics
18th Century French Art Theory
18th Century moral philosophy
neoclassicism
aesthetic experience
Opis:
In the early 18th century, British art theory was an almost virgin field, open to inevitable influences from the continent. Anthony Ashley Cooper, the Third Lord of Shaftesbury, who devoted the last years of his life to various problems of art, made an attempt to create the first serious theory of art in England. In this article, I try to show that Shaftesbury was faced with the need to choose between two competing approaches to art widespread in France at the turn of the century: the traditional approach, based on the poetic understanding of painting, the essence of which was history and its moral meaning, and the new one, proposed by Roger de Piles, based on the action of color and light and shade, which create a comprehensive visual effect independent of the story presented in the picture. Shaftesbury took a traditional approach, driven by moral fears and rather reluctant to make sensual pleasure the goal of art. At the same time, he appropriated the key concepts of Roger de Piles: the pictorial unity and the whole picture, ignoring the ideas associated with them. This should be understood as a half-measure that allowed him to modernize the language of art without the danger of compromising the moral importance of painting.
Źródło:
Rocznik Historii Sztuki; 2020, 45; 31-40
0080-3472
Pojawia się w:
Rocznik Historii Sztuki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Imaging of hypoxia in small animals with 18F fluoromisonidasole
Autorzy:
Kilian, K.
Rogulski, Z.
Cheda, Ł.
Drzał, A.
Gerszewska, M.
Cudny, M.
Elas, M.
Powiązania:
https://bibliotekanauki.pl/articles/148618.pdf
Data publikacji:
2016
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
18F-fluoromisonidazole
radiopharmaceuticals
hypoxia imaging
Opis:
A method of automated synthesis of [18F]fluoromisonidazole ([18F]FMISO) for application in preclinical studies on small animals was presented. A remote-controlled synthesizer Synthra RNplus was used for nucleophilic substitution of NITTP (1-(2'-nitro-1'-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonyl-propanediol) with 18F anion. Labeling of 5 mg of precursor was performed in anhydrous acetonitrile at 100°C for 10 min, and the hydrolysis with HCl was performed at 100°C for 5 min. Final purifi cation was done with high-performance liquid chromatography (HPLC) and the radiochemical purity of radiotracer was higher than 99%. Proposed [18F]FMISO synthesis was used as a reliable tool in studies on hypoxia in Lewis lung carcinoma (LLC) in mouse models.
Źródło:
Nukleonika; 2016, 61, 2; 119-223
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Harmonic mitigation in 18-pulse rectifier based on zigzag autotransformer by DC side auxiliary circuit
Autorzy:
Liu, Jiongde
Chen, Xiaoqiang
Wang, Ying
Chen, Tao
Powiązania:
https://bibliotekanauki.pl/articles/949860.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
18-pulse rectifier
harmonic suppressing
zigzag autotransformer
Opis:
To improve the power quality of a multi-pulse rectifier, a zigzag 18-pulse uncontrolled rectifier with an auxiliary circuit at the DC side is proposed. When the grid-side currents are sinusoidal waves, the required DC side injection currents to be compensated can be obtained by analyzing the AC-DC side relationship of diode bridge rectifiers. Then the 6 compensation currents generated by an active auxiliary circuit are injected into the DC side to eliminate the grid-side harmonics of the rectifier. The simulation results verifying the correctness of the theoretical analysis show that the proposed rectifier can mitigate the harmonic content, as the total harmonic distortion of the grid-side current is about 1.45%. In addition, the single-phase inverter used in the active auxiliary circuit has the characters of simple circuit structure and easy controllability.
Źródło:
Archives of Electrical Engineering; 2020, 69, 4; 891-905
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Extraction of rubidium ion from brine solutions by dicyclohexano-18-crown-6 / ionic liquid system
Autorzy:
Huang, Dongfang
Ma, Guixiang
Lv, Peng
Zhou, Quanbao
Powiązania:
https://bibliotekanauki.pl/articles/2204138.pdf
Data publikacji:
2023
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Rubidium
Ionic liquid
Dicyclohexano-18-crown-6
Solvent extraction
Opis:
Separation among rubidium and potassium ions from salt lake brines remains challenging. In this work, a typical room temperature ionic liquid 1-ethyl-3-metyhlimidazaolium bis(trifluoromethylsulfonyl)imide ([C2mim+][NTf2-]) was used as diluent and synergistic extractant, dicyclohexano-18-crown-6 (DCH18C6) was used as extractant to extract rubidium ions from brine solutions which contain high concentrations of potassium ions was investigated. Under the optimal conditions, the single extraction efficiency of rubidium ions was up 93.63%. The thermodynamic parameters of the rubidium ion extraction were obtained. Based on the slope analysis method, the extracted species in the organic phase were ascertained as 1:1 complex. UV-visible has been performed to investigate the ion concentration of ionic liquid before and after the interaction of metal ions and ligands. Rubidium ions in [Rb · DCH18C6]+ complex were stripped by 2.5 mol · L–1 NH4NO3. The extraction system offers high efficiency, simplicity and environmentally friendly application prospect to separate rubidium from brine solutions.
Źródło:
Polish Journal of Chemical Technology; 2023, 25, 1; 61--68
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 752

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