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Wyszukujesz frazę "total body irradiation (TBI)" wg kryterium: Temat


Wyświetlanie 1-2 z 2
Tytuł:
Effect of scattered radiation in the total body irradiation technique: evaluation of the spoiler and wall dose component in the depthdose distribution
Autorzy:
Piotrowski, T.
Adamska, K.
Malicki, J.
Powiązania:
https://bibliotekanauki.pl/articles/147640.pdf
Data publikacji:
2007
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
total body irradiation (TBI)
scattered radiation
leukaemia
Opis:
To determine the additional dose in layers of the body close to the skin during total body irradiation (TBI), due to radiation scattered off the treatment room walls and behind plexiglass spoilers applied to improve dose uniformity within the irradiated body. Large-field 6, 15 and 25 MV photon beams were generated by a Saturn 43 medical accelerator. A solid 30 ´ 30 ´ 30 cm3 PMMA (polymethylmethacrylate) phantom was used to represent radiation scattered from the body of the patient. Dose distributions were measured by a Farmer ionization chamber. The dose component arising from the spoiler was measured 5 mm below the phantom surface, over distances of 5-100 cm between the spoiler and the phantom surface. To measure the contribution of backscattered radiation from the walls, a small lead block was placed between the source and detector. Measurements were carried out in air with the PMMA phantom removed, to eliminate radiation backscattered from the phantom. As measured behind the spoiler, attenuation of the primary photon beam by the spoiler itself was by 8, 5 and 3% for 6, 15 and 25 MV beams, respectively. The highest dose contribution from the spoiler arose at 10 cm separation between the phantom surface and the spoiler. Assessed at a depth of 5 mm in the phantom, at spoiler-phantom separation of 10 cm, relative to case without spoiler and with wall backscatter subtracted, the dose enhancement due to the spoiler was by 8, 13 and 20% at beam energies 6, 15 and 25 MV, respectively. In these measurements, the distance between the source and the phantom surface was 300 cm and that between the source and the spoiler - 290 cm. The dose contributions due to radiation backscattered from the walls, relative to the case without any wall backscatter, estimated over the distal side of the phantom at a distance of 20 cm between the wall and that side of the phantom, were 5, 6 and 8% at beam energies 6, 15 and 25 MV, respectively. The use of a spoiler enhanced the dose in regions close to the phantom surface, compensating for the dose decrease over that area due to build-up effect. Radiation backscattered from the wall enhanced the dose in regions close to the phantom surface facing the wall.
Źródło:
Nukleonika; 2007, 52, 4; 153-158
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evolution of treatment planning and dose delivery methods during radiotherapy for patients undergoing bone marrow transplantation : a review
Autorzy:
Litoborska, Joanna
Piotrowski, Tomasz
Jodda, Agata
Malicki, Julian
Powiązania:
https://bibliotekanauki.pl/articles/147607.pdf
Data publikacji:
2020
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
total body irradiation
total marrow irradiation
TBI/TMI planning
TBI/TMI dose delivery
Opis:
Background and objectives: This study describes the treatment planning and dose delivery methods of radiotherapy for patients undergoing bone marrow transplantation. The analysis was carried out in the context of the evolution of these methods over the last 60 years. Materials and methods: A systematic literature search was carried out using the PubMed search engine. Overall, 90 relevant studies were included: 24 general studies, 10 describing isotopes usage, 24 related to conventional and 32 to advanced methods. Results: The analysis of the evolution of radiotherapy methods shows how signifi cantly the precision of dose planning methods and its delivery have changed. The atypical positioning caused by geometrical requirements for applications of isotopes or conventional techniques has been replaced by positioning on a therapeutic couch, which allows a more precise setup of the patient that is necessary for an exact delivery of the planned dose. The dose can be fully optimized and calculated on tomographic images by algorithms implemented in planning systems. Optimization process allows to reduce doses in organs at risk. The accuracy between planned and delivered doses can be checked by pretreatment verifi cation methods, and the patient positioning can be checked by image guidance procedures. Interpretation and conclusions: Current radiotherapy solutions allow a precise delivery of doses to the planning target volume while reducing doses to organs at risk. Nevertheless, it should be kept in mind that establishing radiotherapy as an important element of the whole therapeutic regimen resulted from the follow-up of patients treated by conventional techniques. To confi rm the clinical value of new advanced techniques, clinical trials are required.
Źródło:
Nukleonika; 2020, 65, 1; 19-30
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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