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Tytuł:
Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients
Autorzy:
Golembiewska, Edyta
Safranow, Krzysztof
Ciechanowski, Kazimierz
Bober, Joanna
Bogacka, Anna
Stepniewska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1039455.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
peritoneal dialysis
serum adiponectin
serum leptin
solute transport
Opis:
Aim: Adiponectin and leptin are two adipokines playing important roles in the regulation of body weight, appetite, carbohydrate and lipid metabolism. In patients with chronic kidney disease (CKD) adipokines accumulate in serum due to reduced renal clearance. Since adipokines have pleiotropic actions, the adipokine balance may have an impact on peritoneal membrane transport. The aim of this study was to assess whether serum adiponectin and leptin levels were related to peritoneal transport and residual renal function (RRF) in newly started peritoneal dialysis patients. Methods: 25 clinically stable patients, 4 to 6 weeks after the onset of PD, were included in the study. For each patient clinical and laboratory data were reviewed and standard PET test was performed. Serum adiponectin and leptin concentrations were determined and leptin/adiponectin (L/A) ratio was calculated. Results: Serum adiponectin correlated negatively with weight, BMI and glucose concentration. Serum leptin and L/A ratio correlated positively with BMI. Serum adiponectin correlated positively with dialysate to plasma (D/P) creatinine ratio and ultrafiltration in PET test. Serum leptin level and L/A ratio correlated strongly negatively with peritoneal creatinine clearance. Conclusions: Serum adiponectin concentration is positively associated with baseline solute transport. Leptin concentration and L/A ratio are negatively associated with dialysis adequacy in newly started PD patients.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 617-621
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An attempt to use the serum concentration of the phosphate (Pi) and the Ca x P productas markers of the progression of chronic kidney disease in cats
Autorzy:
Sławuta, P.
Kumiega, E.
Sikorska-Kopyłowicz, A.
Sapikowski, G.
Kurosad, A.
Powiązania:
https://bibliotekanauki.pl/articles/2087386.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
chronic kidney disease (CKD)
serum phosphate concentration
serum Ca x Pproduct
cats
Źródło:
Polish Journal of Veterinary Sciences; 2019, 4; 647-652
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dynamic changes of immunoglobulin concentrations in pig colostrum and serum around parturition
Autorzy:
Markowska-Daniel, I
Pomorska-Mol, M.
Pejsak, Z.
Powiązania:
https://bibliotekanauki.pl/articles/30942.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pig
serum
colostrum
immunoglobulin
immunity
dynamic change
parturition
perinatal period
piglet
porcine serum
Opis:
The aim of the study was the determination of IgA, IgM and IgG concentrations in porcine serum and colostrum, in order to evaluate their variations in the perinatal period, as well as to clarify whether there is a correlation between colostrum intake, initial level of immunoglobulins (Ig) in piglet serum and development of their own immunity. The mean IgA, IgM and IgG concentrations in sow serum 10 days before parturition were 1.58, 6.12 and 39.56 mg/ml, respectively. Seven days later only the IgG level was insignificantly lower (34.94 mg/ml, p=0.55), while concentrations of IgA and IgM increased to 2.25 and 7.25 mg/ml, respectively (p=0.23 and 0.62, respectively). The mean initial IgG concentration in colostrum at farrowing was 118.5 mg/ml and differed between sows. The average value of IgA in colostrum at birth was 23.8 mg/ml and decreased to 7.85 mg/ml at 6 hours (h) and to 4.59 mg/ml at 24 h after the onset of farrowing. IgM concentration at birth was 12.1 mg/ml and decreased to 4.23 mg/ml at 24 h postpartum. Positive relationships were found between concentrations of IgM and IgA in serum of piglets at 14 and 56 days of life (r = 0.41 and 0.80, respectively, p≤0.05) as well as for IgG concentration in the piglets serum at 7 days and 56 days of age (r = 0.48, p≤0.05). The above observations suggest that there is a correlation between the level of Ig in piglet serum in the first days of life and improvement of their own immunity.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 1; 21-27
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Barwniki skwaryliowe jako sondy fluorescencyjne do oznaczania biocząsteczek
Skwarylium dyes as fluorescence probes for biomolecules determination
Autorzy:
Jurek, K.
Kabatc, J.
Powiązania:
https://bibliotekanauki.pl/articles/159602.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Elektrotechniki
Tematy:
sondy fluorescencyjne
barwniki skwaryliowe
serum albuminy wołowej
squarylium dyes
fluorescent probes
bovine serum albumin
Opis:
Chemiczna modyfikacja struktury barwników skwaryliowych daje nowe układy chromoforowe o szerokim zakresie właściwości optycznych, takich jak absorpcja światła i emisja fluorescencji, z zakresu światła od widzialnego do bliskiej podczerwieni. Otrzymano nowe funkcjonalne barwniki, w których pod wpływem bodźca zewnętrznego lub oddziaływań chemicznych, zachodzą zmiany w rozmieszczeniu ładunku elektronowego w chromoforze skwaryliowym. Z uwagi na wyraźne zmiany ich właściwości spektroskopowych pod wpływem połączenia z substancją analizowaną, mogą zaleźć praktyczne zastosowanie, jako markery fluorescencyjne do oznaczania biocząsteczek.
Chemical modification of the structure of squarylium dyes gives a new chromophoric systems that have a wide range of optical properties, such as the light absorption and fluorescence emission in the range from the visible light to the near infrared one. The new functional dyes in which the changes of the electron charge distribution in chromophore under the influence of an external stimulus or chemical undergo have been obtained. The interaction between dye and analyte leads to the significant changes of their spectroscopic properties. It can give the possibility of practical application of these new dyes as the fluorescent markers for biomolecules labeling.
Źródło:
Prace Instytutu Elektrotechniki; 2015, 268; 57-64
0032-6216
Pojawia się w:
Prace Instytutu Elektrotechniki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The detection of specific acute phase serum protein complexes and immune complexes by Congo Red binding
Autorzy:
Rybarska, J
Konieczny, L.
Piekarska, B.
Stopa, B.
Roterman, I.
Powiązania:
https://bibliotekanauki.pl/articles/70851.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
serum protein
hemoglobin
human serum
acute phase
Congo Red
rabbit
antibody
haptoglobin
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum metallothionein in newly diagnosed patients with childhood solid tumours
Autorzy:
Krizkova, Sona
Masarik, Michal
Majzlik, Petr
Kukacka, Jiri
Kruseova, Jarmila
Adam, Vojtech
Prusa, Richard
Eckschlager, Tomas
Stiborova, Marie
Kizek, Rene
Powiązania:
https://bibliotekanauki.pl/articles/1040324.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cancer
Brdicka reaction
serum
marker
metallothionein
Opis:
Tumour markers are substances produced by malignant cells or by the organism as a response to cancer development. Determination of their levels can, therefore, be used to monitor the risk, presence and prognosis of a cancer disease or to monitor the therapeutic response or early detection of residual disease. Time-consuming imaging methods, examination of cerebrospinal fluid or tumour tissue and assays for hormones and tumour markers have been used for cancer diagnosis. However, no specific marker for diagnosis of childhood solid tumours has been discovered yet. In this study, metallothionein (MT) was evaluated as a prospective marker for such diseases. Serum metallothionein levels of patients with childhood solid tumours were determined using differential pulse voltammetry - Brdicka reaction. A more than 5-fold increase in the amount of metallothionein was found in sera of patients suffering from cancer disease, compared with those in sera of healthy donors. The average metallothionein level in the sera of healthy volunteers was 0.5 ± 0.2 μmol · dm-3 and was significantly different (p<0.05, determined using the Schefe test) from the average MT level found in serum samples of patients suffering from childhood solid tumours (3.4 ± 0.8 μmol · dm-3). Results found in this work indicate that the MT level in blood serum can be considered as a promising marker for diagnostics, prognosis and estimation of therapy efficiency of childhood tumours.
Źródło:
Acta Biochimica Polonica; 2010, 57, 4; 561-566
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
How dose walking exercise affect serum lipids in underweight female adults?
Autorzy:
Habibzadeh, N.
Powiązania:
https://bibliotekanauki.pl/articles/1917590.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
walking exercise
serum lipids
underweight women
Opis:
Introduction:Fat profile is an extremely important substrate for muscle contraction, both at rest and during exercise as yet, there is still no clear consequence of exercise on lipid profile regulation in underweight subjects and thus the purpose of this study was to compare lipids serums in underweight young women (BMI≤ 20) before and after walking intervention.Materials and methods:20 underweight young non-athlete women volunteered to participate in this study and then they were randomly assigned into two exercise (E: n=10, BMI=17.8±1.2, age: 21.1±1.7yr) and control (C: n=10, BMI=17.5 ±1.1, age: 21.9 ± 1.2) groups. Pre and post assessment were contained somatic (age, height, weight, BMI) and lipids profile (FBS, LDL, HDL, triglycerides and totalcholesterol) measurements. Exercise programme was consisted of 30-minutesupervised walking exercise at 60 % HR max at intensity equal with 40% VO2max 3 days per week for 2 months.Results:Data analysis showed post-BMI as well as body weight did not altered in comparison with pre - exercise programme (p>0.05). Subsequently all post - lipids variables included FBS, LDL, HDL, triglycerides and totalcholesterol were elevated compared with pre- intervention walking exercise (p< 0.05.)Conclusions:This study outlined that walking programme can be a stimuli toward ideal weight in slim individual because an increased lipids profile as indicators of an increased body mass in underwent individual who are at risk of diseases such as anorexia nervosa shows this notion. However, more investigation with longer duration is needed to justify thisconclusion.
Źródło:
Progress in Health Sciences; 2015, 5, 2; 249-252
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diagnostic values of calcium and magnesium forms determined in human serum and saliva
Wartosc diagnostyczna form wapnia i magnezu oznaczonych w ludzkiej surowicy krwi i slinie
Autorzy:
Andrusishina, I N
Powiązania:
https://bibliotekanauki.pl/articles/15539.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
diagnostic value
calcium form
magnesium form
determination
human serum
serum
human saliva
saliva
atomic absorption spectrometry
Opis:
Calcium and magnesium are known to be necessary for the normal function of various systems in animal and human organisms. There are many diseases caused by abnormal concentration of electrolytes, e.g. arterial hypertension or nervous system diseases such as multiple sclerosis, Mb. Alzheimer or Mb. Parkinson. The mechanisms of homeostasis indicate only the ionized forms of these elements. It is known that ionized calcium serves as an endocellular intermediary in action of enzymes and hormones in cells. Therefore, it is very important to define levels of total and ionized forms of Ca2+ and Mg2+ in blood serum and saliva by the method of atomic absorption spectrometry and to show their diagnostic value for various pathological conditions of a human body. The 39 persons, aged 21 to 47 years take part in these investigations. The results of determinations of calcium and magnesium forms present in human serum and saliva, representing physiological states are presented. The age and daily fluctuations of Ca2+ and Mg2+ content in serum and saliva were studied by atomic absorption spectrometry. The levels of non albumin forms of these elements were found by FAAS. The significance of determination of calcium and magnesium levels in serum and saliva under various pathological conditions (arterial hypertension and osteoporosis) was shown.
Wapń i magnez to pierwiastki niezbędne do prawidłowego funkcjonowania organizmów zwierzęcych i ludzkich. Istnieje wiele chorób wywoływanych przez nieprawidłowe stężenia elektrolitów, np. nadciśnienie tętnicze lub choroby układu nerwowego, takie jak SM, choroba Alzheimera lub Parkinsona. Mechanizmy homeostazy wskazują jedynie na zjonizowane formy tych pierwiastków. Wiadomo, że zjonizowana forma wapnia służy jako międzykomórkowy pośrednik między enzymami i hormonami w komórkach. Dlatego tak ważne jest określenie zawartości całkowitych tych pierwiastków oraz jonów Ca2+ i Mg2+ w surowicy krwi oraz w ślinie za pomocą metody absorpcyjnej spektrometrii atomowej oraz wykazanie ich roli w diagnostyce różnych stanów patologicznych w organizmie człowieka. Badaniami objęto 39 osób w wieku od 21 do 47 lat. W pracy przedstawiono wyniki oznaczeń form wapnia i magnezu występujących w ludzkiej surowicy krwi oraz ślinie odpowiadające stanom fizjologicznym. Wahania w zawartości Ca2+ i Mg2+ w surowicy i ślinie, w zależności od wieku i pory dnia, badano za pomocą aborpcyjnej spektrofotometrii atomowej. Zawartości niealbuminowych form tych pierwiastków określono za pomocą FAAS. Wykazano istotność oznaczeń zawartości wapnia i magnezu dla różnych stanów chorobowych (nadciśnienie tętnicze, osteoporoza).
Źródło:
Journal of Elementology; 2010, 15, 3; 425-433
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of bovine serum albumin glycated with glucose, galactose and lactose
Autorzy:
Ledesma-Osuna, Ana
Ramos-Clamont, Gabriela
Vázquez-Moreno, Luz
Powiązania:
https://bibliotekanauki.pl/articles/1040702.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bovine serum albumin glycoconjugates
Maillard reaction
glycation
Opis:
The non-enzymatic reaction between reducing sugars and proteins, known as glycation, has received increased attention from nutritional and medical research. In addition, there is a large interest in obtaining glycoconjugates of pure well-characterized oligosaccharides for biological research. In this study, glycation of bovine serum albumin (BSA) by d-glucose, d-galactose and d-lactose under dry-heat at 60°C for 30, 60, 120, 180 or 240 min was assessed and the glycated products studied in order to establish their biological recognition by lectins. BSA glycation was monitored using gel electrophoresis, determination of available amino groups and lectin binding assays. The BSA molecular mass increase and glycation sites were investigated by mass spectrometry and through digestion with trypsin and chymotrypsin. Depending on time and type of sugar, differences in BSA conjugation were achieved. Modified BSA revealed reduction of amino groups' availability and slower migration through SDS/PAGE. d-galactose was more reactive than d-glucose or d-lactose, leading to the coupling of 10, 3 and 1 sugar residues, respectively, after 120 minutes of reaction. BSA lysines (K) were the preferred modified amino acids; both K256 and K420 appeared the most available for conjugation. Only BSA-lactose showed biological recognition by specific lectins.
Źródło:
Acta Biochimica Polonica; 2008, 55, 3; 491-497
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterisation of alginate micro- and nanospheres loaded with bovine serum albumin
Autorzy:
Wirecka, R.
Arruebo, M.
Sebastian, V.
Kyzioł, A.
Powiązania:
https://bibliotekanauki.pl/articles/284154.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
drug delivery systems
bovine serum albumin
synthesis
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 35
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
miRNA-146a-5p is upregulated in serum and cartilage samples of patients with osteoarthritis
Autorzy:
Skrzypa, Marzena
Szala, Dariusz
Gablo, Natalia
Czech, Joanna
Pajak, Justyna
Kopanska, Marta
Trzeciak, Mateusz
Gargasz, Krzysztof
Snela, Sławomir
Zawlik, Izabela
Powiązania:
https://bibliotekanauki.pl/articles/1391948.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
circulating microRNA
osteoarthritis
serum
cartilage
biomarker
Opis:
Introduction: Osteoarthritis (OA) is a widely prevalent joint disease leading to motor disability and pain. Appropriate indicators for identifying patients at risk for this progressive disease, identifying molecular events for detecting early phases of the disease, or biomarkers to screen for treatment responses, however, are lacking. Micro RNAs (miRNAs), which play crucial roles in OA, could be potential biomarkers of OA. Because circulating miRNA levels reflect the disease state, they may be useful for OA screening and as diagnostic tools, reducing the need for invasive procedures and minimizing the cost of current diagnostic methods. Materials and methods: The expression levels of 18 microRNAs (let-7e-5p, miR-21-5p, miR-93-5p, miR-101-3p, miR-103a-3p, miR-130a-3p miR-146a-5p, miR-16-5p, miR-193b-3p miR-199a-3p, miR-210-3p, miR-222-3p, miR-22-3p, miR-27a-3p, miR-27b-3p, miR-335-5p, miR-454-3p, and miR-98-5p) were analyzed by quantitative real-time polymerase chain reaction in the cartilage tissues and serum samples of 28 OA patients and were compared to those of 2 healthy controls. Results: Expression of microRNA-146a-5p was significantly upregulated in the cartilage (p=0.006) and serum (p=0.002) of OA patients. The expression levels of miR-146a-5p in the serum were positively correlated with those in the cartilage (Pearson correlation coefficient R=0.32; p=0.002). Conclusion: miR-146a-5p was significantly overexpressed in patients with OA, both in the articular cartilage tissue and serum, with a positive correlation between the levels in both types of samples. Therefore, the miR-146a-5p serum level could reflect the molecular processes in the cartilage, suggesting its clinical utility as a biomarker for OA management. Implementing noninvasive biomarker using serum miRNAs involves the analysis of the misregulated miRNAs linked to the cartilage pathology.
Źródło:
Polish Journal of Surgery; 2019, 91, 3; 1-5
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Panel of serum metabolites discriminates cancer patients and healthy participants of lung cancer screening - a pilot study
Autorzy:
Roś-Mazurczyk, Małgorzata
Wojakowska, Anna
Marczak, Łukasz
Polański, Krzysztof
Pietrowska, Monika
Polanska, Joanna
Dziadziuszko, Rafał
Jassem, Jacek
Rzyman, Witold
Widlak, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1038611.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
early detection
lung cancer screening
metabolomics
serum biomarkers
Opis:
Introduction. Blood biomarkers may support early diagnosis of lung cancer by enabling pre-selection of candidates for computed tomography screening or discrimination between benign and malignant screening-detected nodules. We aimed to identify features of serum metabolome distinguishing individuals with early-detected lung cancer from healthy participants of the lung cancer screening program. Methods. Blood samples were collected in the course of a low-dose computed tomography screening program performed in the Gdansk district (Northern Poland). The analysis included 31 patients with screening-detected lung cancer and the pair-matched group of 92 healthy controls. The gas chromatography coupled to mass spectrometry (GC/MS) approach was used to identify and quantify small metabolites present in serum. Results. There were several metabolites detected in the sera whose abundances discriminated patients with lung cancer from controls. Majority of the differentiating components were downregulated in cancer samples, including amino acids, carboxylic acids and tocopherols, whereas benzaldehyde was the only compound significantly upregulated. A classifier including nine serum metabolites allowed separation of cancer and control samples with 100% sensitivity and 95% specificity. Conclusions. Signature of serum metabolites discriminating between cancer patients and healthy participants of the early lung cancer screening program was identified using a GC/MS metabolomics approach. This signature, though not validated in an independent dataset, deserves further investigation in a larger cohort study.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 513-518
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A simple method for the determination of the cholesterol esterase activity
Autorzy:
Stępień, Agnieszka
Gonchar, Mykhailo
Powiązania:
https://bibliotekanauki.pl/articles/1039538.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cholesterol esterase
cholesterol
activity determination
human serum
Opis:
The proposed method determines the activity of cholesterol esterase (CEH) and takes advantage of its ability to catalyze the hydrolysis of cholesterol esters naturally present in human serum. The assay is based on Allain's method of spectrophotometric determination of cholesterol by means of cholesterol oxidase, peroxidase, but using 3,5-dichloro-dihydroxybenzenesulfonic acid (DHBS) as phenolic chromogen and human serum as a source of substrate for the CEH as a novelty. Furthermore, it is characterized by low costs and high precision. It can be employed to control the activity of CE preparations used for the preparation of enzymatic kits for the determination of cholesterol or for screening of potential bacterial enzyme producers.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 401-403
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Infuence of HbA1c, serum lipids, blood pressure and BMI on Auditory Brainstem Response in diabetic patients
Autorzy:
Dąbrowski, Mariusz
Mielnik-Niedzielska, Grażyna
Nowakowski, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/454729.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
auditory brainstem response diabetes mellitus
serum lipids
Opis:
Introduction. Impaired hearing organ function including abnormalities in auditory brainstem response (ABR) are more frequent in diabetic subjects compared to the general population. The aim of our study was to assess the impact of selected modifiable factors on ABR latencies in diabetic subjects. Material and Methods. 58 patients with type 1 and type 2 diabetes, aged <45 years, with diabetes duration <10 years, and without clinically overt hearing impairment or diabetic neuropathy, were included. In all subjects vital signs and blood samples were obtained, and ABR audiometry was performed. Results. Significantly delayed latencies in ABR were found in patients with total cholesterol <192 mg/dL, with HDL-cholesterol <49.5 mg/dL, with triglycerides >89 mg/dL, with presence of hypertension, and with systolic and diastolic blood pressure >135 and >78 mm Hg respectively. A linear correlation between triglycerides and wave I and III latencies, and between systolic blood pressure and wave III latency were revealed. A relationship between ABR latencies and HbA1c, LDL-cholesterol or BMI was not found. Conclusions. Several modifiable factors affect functioning of the retrocochlear part of the auditory pathway. If these results were confirmed in further studies, a vast area of possible therapeutic interventions to preserve hearing function in diabetic patients would become available.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 3; 185-191
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Osocze vs surowica – czy rodzaj materiału biologicznego ma wpływ na wyniki oznaczeń parathormonu?
Plasma vs serum – does the type of biological material affects the results of parathyroid hormone determinations?
Autorzy:
Beda-Maluga, Karolina
Paczuszka, Paulina
Pisarek, Hanna
Świętosławski, Jacek
Winczyk, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1035389.pdf
Data publikacji:
2019
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
surowica
osocze
parathormon
serum
plasma
parathyroid hormone
Opis:
Introduction: The recommended biological material for the parathyroid hormone (PTH) assay is venous blood plasma. According to diagnostic kit manufacturers, the PTH concentration can also be determined in blood serum. The aim of the study was to determine whether differences exist between PTH measured in serum and in plasma. Material and methods: The study was conducted on venous blood samples (plasma and serum) obtained from 92 patients at the Clinic of Endocrinology, University Hospital WAM – CSW. The PTH concentration was measured with an Immulite 1000 analyzer (Siemens), and iPTH kit. Results: The PTH values in plasma and serum were the same only in 3 cases. In 46 samples (50%), a higher hormone level was observed in the plasma, and in 43 cases (47%), a higher concentration was obtained in serum. The absolute differences between the PTH values in the tested biological materials ranged from 0 to 38 pg/mL, and increased together with the hormone concentration. The relative differences (percentage ratio of absolute differences to plasma PTH concentration) ranged from 0 to 34.3%. However, neither the absolute nor the relative differences were statistically significant (p > 0.05). The classification of PTH concentrations according to the reference values for each biological material (i.e. normal, reduced or elevated) was found to be concordant in 83 tested samples (90%). Conclusion: The identified PTH concentrations in the plasma and serum were not identical but comparable and in most cases the differences did not affect the clinical interpretation of the results.
WSTĘP: Materiałem biologicznym zalecanym do oznaczania parathormonu (parathyroid hormone – PTH) jest osocze krwi żylnej pobranej na wersenian sodowo-potasowy, jednak według producentów zestawów diagnostycznych do pomiaru PTH można stosować zarówno osocze, jak i surowicę krwi. Celem pracy było zbadanie, czy wartości PTH oznaczane w surowicy i w osoczu krwi żylnej są porównywalne. MATERIAŁ I METODY: W badaniu wykorzystano próbki krwi żylnej (osocze i surowica) uzyskane od 92 pacjentów Poradni Endokrynologicznej Uniwersyteckiego Szpitala Klinicznego im. Wojskowej Akademii Medycznej – Centralnego Szpitala Weteranów (USK im. WAM – CSW) w Łodzi. Oznaczenia hormonu wykonano na analizatorze Immulite 1000 (Siemens) zestawem iPTH. WYNIKI: Wartości PTH oznaczone w osoczu i w surowicy były jednakowe tylko w 3 przypadkach. W 46 próbkach (50%) wyższe wartości hormonu odnotowano w osoczu, a w 43 przypadkach (47%) w surowicy. Różnice bezwzględne między wartościami PTH w badanych materiałach wahały się od 0 do 38 pg/mL i zwiększały się wraz ze wzrostem stężenia hormonu. Różnice względne (procentowy stosunek różnic bezwzględnych do stężenia PTH w osoczu) wynosiły od 0 do 34,3%. Jednak zarówno różnice bezwzględne, jak i względne nie były znamienne statystycznie (p > 0,05). Po klasyfikacji stężeń – na prawidłowe, obniżone lub podwyższone – na podstawie wartości referencyjnych PTH dla danego materiału biologicznego uzyskano zgodność wyników w 83 badanych próbkach (90%). WNIOSKI: Stężenia PTH oznaczane w osoczu i w surowicy nie są identyczne, ale porównywalne, a różnice w większości przypadków nie wpływają na interpretację kliniczną wyników.
Źródło:
Annales Academiae Medicae Silesiensis; 2019, 73; 25-30
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 123

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