Temat: domain specificity - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Zur Spezialisierung des Arbeitsgedächtnisses auf die Satzverarbeitungsprozesse
Specialization of working memory for the sentence processing
Autorzy:: Sękowska, Jolanta
Powiązania:: https://bibliotekanauki.pl/articles/967421.pdf
Data publikacji:: 2015
Wydawca:: Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:: Modularity
sentence processing
sentence comprehension
working memory
domain specificity
Opis:: Constructing dependency relations, in particular subject-verb agreement, in languages in which verbs may occupy the final position in the sentence, requires a combination of newly appearing lexical items with the existing context, such that it extends beyond the limits of the phrase. New words can be integrated only if the part of the sentence that has already been processed remains in a state of activation, being open to receive new elements. This article focuses on the question of the specificity for the domain of linguistic knowledge of the working memory, as the cognitive system in which representations are temporarily stored and manipulated.
Źródło:: Acta Universitatis Lodziensis. Folia Germanica; 2015, 11; 93-107
2449-6820
Pojawia się w:: Acta Universitatis Lodziensis. Folia Germanica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 2.

Tytuł:: Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG
Autorzy:: Smietana, Katarzyna
Kasztura, Monika
Paduch, Marcin
Derewenda, Urszula
Derewenda, Zygmunt
Otlewski, Jacek
Powiązania:: https://bibliotekanauki.pl/articles/1040739.pdf
Data publikacji:: 2008
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: binding specificity
LARG
PDZ domain
PDZRhoGEF
phage display
Opis:: PDZ domains are ubiquitous protein-protein interaction modules which bind short, usually carboxyterminal fragments of receptors, other integral or membrane-associated proteins, and occasionally cytosolic proteins. Their role in organizing multiprotein complexes at the cellular membrane is crucial for many signaling pathways, but the rules defining their binding specificity are still poorly understood and do not readily explain the observed diversity of their known binding partners. Two homologous RhoA-specific, multidomain nucleotide exchange factors PDZRhoGEF and LARG contain PDZ domains which show a particularly broad recognition profile, as suggested by the identification of five diverse biological targets. To investigate the molecular roots of this phenomenon, we constructed a phage display library of random carboxyterminal hexapeptides. Peptide variants corresponding to the sequences identified in library selection were synthesized and their affinities for both PDZ domains were measured and compared with those of peptides derived from sequences of natural partners. Based on the analysis of the binding sequences identified for PDZRhoGEF, we propose a sequence for an 'optimal' binding partner. Our results support the hypothesis that PDZ-peptide interactions may be best understood when one considers the sum of entropic and dynamic effects for each peptide as a whole entity, rather than preferences for specific residues at a given position.
Źródło:: Acta Biochimica Polonica; 2008, 55, 2; 269-280
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "domain specificity" wg kryterium: Temat

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język