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    Wyświetlanie 1-3 z 3
    Tytuł:
    Anti-cancer activity of Indoneesiella echioides (L.) Nees leaves using KB cells
    Autorzy:
    Elaiyaraja, A.
    Chandramohan, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/1177838.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Anticancer activity
    Indoneesiella echioides (L.) Nees
    KB
    Mitochondria membrane potential
    ROS generation
    normal HGF-1 cell
    Opis:
    Indoneesiella echioides (L.) Nees is a well-known herb used in ethnomedicine. Flavonoids and alkaloids are major constituents of Indoneesiella echioides (L.) Nees. In this study, we investigated the anticancer activity of KB and normal HGF-1 cells. We demonstrated the effects of ethanolic extract of Indoneesiella echioides (L.) Nees on the cell growth and apoptosis in KB and normal HGF-1 cells were analyzed by the generation of reactive oxygen species (ROS), the level of mitochondrial membrane potential (∆ψM) and apoptotic morphological changes were analyzed by AO/EtBr, AO and Hoechst staining. Our results indicated that the ethanolic extracts of Indoneesiella echioides (L.) Nees shows better anticancer activity through it’s induces increased cell death, ROS generation, alteration of mitochondria membrane potential and apoptosis.
    Źródło:
    World Scientific News; 2018, 98; 1-11
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Liver mitochondria and insulin resistance
    Autorzy:
    Vial, Guillaume
    Dubouchaud, Hervé
    Leverve, Xavier
    Powiązania:
    https://bibliotekanauki.pl/articles/1040285.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    oxidative phosphorylation
    insulin resistance
    mitochondria
    membrane potential
    Opis:
    With a steadily increasing prevalence, insulin resistance (IR) is a major public health issue. This syndrome is defined as a set of metabolic dysfunctions associated with, or contributing to, a range of serious health problems. These disorders include type 2 diabetes, metabolic syndrome, obesity, and non-alcoholic steatohepatitis (NASH). According to the literature in the field, several cell types like β-cell, myocyte, hepatocyte and/or adipocyte, as well as related complex signaling environment involved in peripheral insulin sensitivity are believed to be central in this pathology. Because of the central role of the liver in the whole-body energy homeostasis, liver insulin sensitivity and its potential relationship with mitochondrial oxidative phosphorylation appear to be crucial. The following short review highlights how liver mitochondria could be implicated in IR and should therefore be considered as a specific therapeutic target in the future.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 4; 389-392
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Differentiated Paju cells have increased resistance to toxic effects of potassium ionophores.
    Autorzy:
    Teplova, Vera
    Jääskeläinen, Elina
    Salkinoja-Salonen, Mirja
    Saris, Nils-Erik
    Serlachius, Martina
    Li, Feng-Yen
    Andersson, Leif
    Powiązania:
    https://bibliotekanauki.pl/articles/1043288.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cereulide
    Paju cells
    valinomycin
    mitochondria
    cell differentiation
    membrane potential
    Opis:
    In this study we have investigated the impact of differentiation of neuronal cells on their sensitivity to microbial toxins. We used the human neural crest-derived tumor cell line Paju, which can be induced to differentiation in vitro by treatment with phorbol 12-myristate 13-acetate. Addition of the highly toxic potassium ionophores cereulide (4.5 and 9.0 ng/ml) or valinomycin (20 ng/ml), to cultures of undifferentiated Paju cells caused collapse of the mitochondrial membrane potential - measured with the fluorescent probe 5,5',6,6'-tetrachloro-1,1',3,3'-tetrabenzimidazole carbocyanine iodide (JC-1) followed by detachment of the cells and their apoptotic death. After induced differentiation of the Paju cells, their mitochondria retained the membrane potential upon exposure to the toxins and the cells displayed increased resistance to apoptosis as compared with undifferentiated cells. This effect may be caused by an elevated expression of the anti-apoptotic protein Bcl-2 and of the neuroprotective factor, stanniocalcin, in differentiated cells.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 2; 539-544
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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