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    Wyświetlanie 1-2 z 2
    Tytuł:
    Isolation and characterization of novel human short-chain dehydrogenase/reductase SCDR10B which is highly expressed in the brain and acts as hydroxysteroid dehydrogenase*
    Autorzy:
    Huang, Chaoqun
    Wan, Bo
    Gao, Bo
    Hexige, Saiyin
    Yu, Long
    Powiązania:
    https://bibliotekanauki.pl/articles/1040586.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    expression pattern
    clone
    brain
    hydroxysteroid dehydrogenase
    Opis:
    Hydroxysteroid dehydrogenase belongs to the subfamily of short-chain dehydrogenases/reductases (SDR), and 11-β-hydroxysteroid dehydrogenase catalyzes the interconversion of inactive glucocorticoids (cortisone in human, dehydrocorticosterone in rodents) and active glucocorticoids (cortisol in human, corticosterone in rodents). We report here the cloning and characterization of a novel human SDR gene SCDR10B which encodes a protein with similarity to 11β-hydroxysteroid dehydrogenase 1. SCDR10B was isolated from a human brain cDNA library, and was mapped to chromosome 19p13.3 by browsing the UCSC genomic database. It contains an ORF with a length of 858 bp, encoding a protein with a transmembrane helix and SDR domain. Its molecular mass and isoelectric point are predicted to be 30.8 kDa and 10.3 kDa, respectively. SCDR10B protein is highly conserved in mammals and fish. Phylogenetic tree analysis indicated that SCDR10B stands for a new subgroup in the 11β-hydroxysteroid dehydrogenase family. Northern blot analysis showed that SCDR10B was highly expressed in brain, and a strong expression signal was detected in hippocampal neurons by immunohistochemical analysis. RT-PCR and immunohistochemical analysis showed that SCDR10B was up-regulated in lung-cancer cell lines and human lung cancer. SCDR10B can catalyze the dehydrogenation of cortisol in the presence of NADP+, and therefore it is a hydroxysteroid dehydrogenase.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 2; 279-289
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Coevolution of Paleo-Tethys and Rheic: New tectonic constraints from Iran and Turkey
    Autorzy:
    Chu, Yang
    Wan, Bo
    Lin, Wei
    Allen, Mark B.
    Talebian, Morteza
    Uysal, Ibrahim
    Xin, Guangyao
    Powiązania:
    https://bibliotekanauki.pl/articles/24202110.pdf
    Data publikacji:
    2023
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    tectonics
    Iran
    Turkey
    Opis:
    In the Paleozoic, one large ocean once separated the Eurasia of the north and the Gondwana of the south, but it has two names, Paleo-Tethys and Rheic, suggesting different tectonic history. The Paleo-Tethys represent the ocean from east Asia to Middle East regions and vanished in Early Mesozoic, while the Rheic existed across the Europe and finally closed in Carboniferous. The two oceans coevolved for a long time, but the interaction and mutual effect at subduction and collision stages are not well understood. Initiation processes of ocean spreading, subduction and collision are crucial in plate tectonics, so resolving the timing for these turning points may greatly enhanced the precision and accuracy of reconstruction of the two oceans, especially for the western Paleo-Tethys. In NE Iran, we find that all the Paleozoic clastic rocks record two major zircon U-Pb age groups peaked at ~800 Ma and ~600 Ma. Consistency in age patterns show a dominant provenance from Neoproterozoic basement of the north Gondwana and a long-lasting passive margin sedimentation after the spreading of the Paleo-Tethys. This environment was interrupted by initial collision between the Turan (Eurasia) and Central Iran (Gondwana) Blocks with massive coarse clastic deposition, i.e. the protolith of the Mashhad Phyllite, in a peripheral foreland basin on the Paleozoic passive margin. The Mashhad Phyllite yields a striking provenance change from passive margin to active margin. The Paleozoic ages reveal a long-lived subduction zone at the south Turan Block initiated since the latest Ordovician. More importantly, the provenance shift better constrains the initial collision timing with the maximum deposition age of the Mashhad Phyllite (~228 Ma) refining the evolution history of Paleo-Tethys. Based on our new results and previous data, we compare the tectonic history of the Paleo-Tethys in its western segment with eastern Rheic, and further discuss the interaction between the Rheic and Paleo-Tethys. We find existence of a lateral subduction zone plays a crucial rule in initiating new subduction zone after an old oceanic plate vanishes and two continents collides, while a lateral collision can also result into shallowing of subducted slab and preservation of coeval compressional structures. These new insights help us to better interpret the emplacement of high-pressure metamorphic rocks during subduction and subduction zone jump when the Rheic and Paleo-Tethys coevolved.
    Źródło:
    Geotourism / Geoturystyka; 2023, 1-2 (72-73); 15--15
    1731-0830
    Pojawia się w:
    Geotourism / Geoturystyka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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