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    Wyświetlanie 1-6 z 6
    Tytuł:
    Rola wolnych rodników w regulacji procesów fizjologicznych
    Role of free radicals in physiological processes
    Autorzy:
    Gdula- Argasińska, Joanna
    Tyszka- Czochara, Małgorzata
    Paśko, Paweł
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1033782.pdf
    Data publikacji:
    2012
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    hormeza
    reaktywne formy azotu RFN
    reaktywne formy tlenu RFT
    regulacja procesów fizjologicznych
    równowaga redox
    wolne rodniki
    Opis:
    Free radicals containing one or more unpaired electrons have considerable reactivity. Those radicals derived from oxygen represent the most important class of such species. Free radicals generated in organism are reactive oxygen species (ROS) and reactive nitrogen species (RNS) well recognised for playing a dual role as both deleterious and beneficial species. The cumulative production of ROS/RNS is termed oxidative stress and were discovered in pathomechanism of many of diseases. It was observed that in medium concentration ROS and RNS are play a role in inflammation, apoptosis and as secondary messengers in intracellular signalling cascades.
    Źródło:
    Medicina Internacia Revuo; 2012, 25, 99; 41-46
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Identification of lipid derivatives in Hep G2 cells
    Autorzy:
    Gdula-Argasińska, Joanna
    Garbacik, Aneta
    Tyszka-Czochara, Małgorzata
    Woźniakiewicz, Michał
    Paśko, Paweł
    Czepiel, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1039495.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    human hepatocellular carcinoma cells HepG2
    eicosapentaenoic acid
    benzo(a)pyrene
    isoprostanes
    prostaglandins
    UHPLC/MS-TOF method validation
    Opis:
    Metabolism of polyunsaturated fatty acids results in biosynthesis of mediators with different physiological effects. These metabolites include prostaglandins, prostacyclins, isoprostanes and others that are important signalling molecules and regulate a variety of physiological and pathophysiological processes including inflammation. Prostaglandins and isoprostanes are produced by either non-enzymatic lipid peroxidation or by enzyme-induced peroxidation (cyclooxygenases and lipoxygenases). They are used as biomarkers of oxidative stress. The aim of our study was to assess the effect of eicosapentaenoic acid (EPA) supplementation with added benzo(a)pyrene (BaP) on HepG2 cells by using a UHPLC/MS-TOF method. This rapid and simple method was developed for the identification, separation and quantification of 8-iPGF3α, PGF3α, 8-isoPGF2α and 5-iPF2α in cultured cells. The UHPLC/MS-TOF method was validated. The calculated limit of detection was in the range of 0.16-0.50 ng/mL, precision (% RSD): 1.2-2.1% and recoveries better than 88%. This method empowered qualitative and quantitative analysis of the selected individual prostaglandins derived from arachidonic acid and eicosapentaenoic acid from cell extracts.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 4; 811-815
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
    Autorzy:
    Grzywacz, Agata
    Gdula-Argasińska, Joanna
    Muszyńska, Bożena
    Tyszka-Czochara, Małgorzata
    Librowski, Tadeusz
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1038990.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    metal responsive-transcription factor 1
    cell signaling
    inflammation
    NF-κB
    Opis:
    Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 491-498
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zinc, the Trace Element Essential in Living Organisms
    Autorzy:
    SOLÉ PASCUAL, Anna
    TYSZKA-CZOCHARA, Małgorzata
    GDULA-ARGASIŃSKA, Joanna
    LIBROWSKI, Tadeusz
    GRZYWACZ, Agata
    OPOKA, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1033792.pdf
    Data publikacji:
    2012
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    biochemistry of zinc
    zinc functions
    Opis:
    Zinc is a metallic element, of symbol Zn and atomic number 30, that is placed in the group 12 of the periodic table. As an essential trace element, zinc is required to support human biochemical processes. It is found in nearly 200 specific enzymes in the living organisms, and it also serves as structural cofactor for many cellular proteins. [1] Zinc may exert pleiotropic effects in organism; for that, deficits of cellular zinc content can have catastrophic consequences and are linked to major pathophysiology, such as diabetes, stroke and malformations of brain function [2]. The complexity and importance of zinc homeostasis is reflected by the large variety and number of zinc-related proteins found in almost every cell compartment; for example, this biometal is transported through ZnT (Zn2+ transporter) family and ZIP family, proteins that are completely dedicated to zinc transport [2]. It is also noticeable, that between three and ten percent of all protein products of genes in mammalian genomes bind zinc, which is essential for their folding, activity or conformational change [2].
    Źródło:
    Medicina Internacia Revuo; 2012, 25, 99; 55-59
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fructose Affects Fatty Acids Profile in Liver Cells in Vitro and In Vivo Models in Rats
    Autorzy:
    TYSZKA- CZOCHARA, Malgorzata
    GDULA- ARGASIŃSKA, Joanna
    PAŚKO, Paweł
    LIBROWSKI, Tadeusz
    GAWEŁ, Magdalena
    OLBERT, Magdalena
    LIPKOWSKA, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1033740.pdf
    Data publikacji:
    2014
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    Diet
    Fatty acids profile
    Fructose
    Hep G2 cell culture
    Lipid metabolism
    Opis:
    It was reported that dietary fructose imposes a number of effects on lipid metabolism including hypertriglyceridemia. The daily intake of fructose in humans is mainly due to sucrose. It was reported that the consumption is still increasing, making a background for health implications. The mechanism of metabolic disorders is poorly understood, but a lot of studies indicate that the liver lipid homeostasis deregulation is essential for a fructose effect on metabolism. The aim of the study is to estimate if fructose affects the profile of fatty acids in in vitro and in vivo models. In this study in vitro and in vivo experiments were conducted to assess the effect of dietary fructose on the fatty acid profile in the cell culture or in the liver of rats. The results showed that in the fructose experimental groups, both in the cell and liver homogenates, the content of the saturated fatty acids were significantly higher than in control groups. According to the obtained data fructose in the medium and in the diet affects saturation of fatty acids in the cell cultures and in the livers of rats. The findings obtained in the experiments support the thesis that fructose influences the homeostasis of lipid metabolism in the liver and may give an opportunity to discuss the limitation of the content of this kind of sugar in food.
    Źródło:
    Medicina Internacia Revuo; 2014, 26, 102; 42- 46
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fatty Acids Profile in Phospholipids of The Erythrocyte Membranes in Swimming Rats
    Autorzy:
    GDULA-ARGASIŃSKA, Joanna
    TYSZKA-CZOCHARA, Małgorzata
    TELEGŁÓW, Aneta
    DĄBROWSKI, Zbigniew
    PAŚKO, Paweł
    LIBROWSKI, Tadeusz
    GAWEŁ, Magdalena
    OLBERT, Magdalena
    LIPKOWSKA, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1033756.pdf
    Data publikacji:
    2014
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    erythrocyte membranes
    fatty acids
    physical activity
    rats
    Opis:
    Alterations in membrane lipid composition, particularly fatty acids content is known to result in functional and structural changes. Dietary lipids and physical activity or stress play an important role in this change. It was of interest to study the influence of swimming in different temperatures on the content of fatty acids in the phospholipids of the erythrocyte membranes of rats. Our research demonstrated a significant influence of swimming on the content of fatty acids in the phospholipids of the erythrocyte membranes of rats. These changes of fatty acids, particularly the decrease of arachidonic acid and significant increase of saturated fatty acids in the phospholipids of the erythrocyte membranes in swimming rats may be induced by oxygen radicals generated in different kinds of stress.
    Źródło:
    Medicina Internacia Revuo; 2014, 26, 102; 19-23
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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