Autor: Swiatkowska, Agata - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Structure and function of RNA elements present in enteroviral genomes
Autorzy:: Dutkiewicz, Mariola
Stachowiak, Aleksandra
Swiatkowska, Agata
Ciesiołka, Jerzy
Powiązania:: https://bibliotekanauki.pl/articles/1038713.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Enterovirus
poliovirus
coxsackievirus B3
RNA structure
structural RNA element
cis-acting element
Opis:: Enteroviruses are small RNA(+) viruses that encode one open reading frame flanked by two extensive noncoding regions carrying structural RNA regulatory elements that control replication and translation processes. For a long time the central, coding region was thought to remain single-stranded and its only function was supposed to be as the template for polyprotein synthesis. It turned out, however, that the protein coding region also encodes important RNA structures crucial for the viral life cycle and virus persistence in the host cells. This review considers the RNA structures in enteroviral genomes identified and characterized to date.
Źródło:: Acta Biochimica Polonica; 2016, 63, 4; 623-630
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The role of the 5 terminal region of p53 mRNA in the p53 gene expression
Autorzy:: Swiatkowska, Agata
Zydowicz, Paulina
Sroka, Joanna
Ciesiołka, Jerzy
Powiązania:: https://bibliotekanauki.pl/articles/1038716.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: p53
transcription
translation
non-coding region
mRNA
IRES
Opis:: The p53 tumour suppressor protein is one of the major factors responsible for cell cycle regulation and protection against cancer development. This is why it is often referred to as "the guardian of the genome". On the other hand, mutations in the p53 gene are connected with more than 50% of tumours of various types. The thirty-six years of extensive research on the p53 gene and its protein products have shown how sophisticated the p53-based cell system control is. An additional level of complexity of the p53 research is connected with at least twelve p53 isoforms which have been identified in the cell. Importantly, disturbance of the p53 isoforms' expression seems to play a key role in tumorigenesis, cell differentiation and cell response to pathogenic bacteria, and RNA and DNA viruses. Expression of various p53 isoforms results from the usage of different transcription promoters, alternative splicing events and translation initiation from alternative AUG codons. The importance of the 5'-terminal regions of different p53 mRNA transcripts in the multi-level regulation of the p53 gene has recently been documented. In this review we focus on the structural features of these regions and their specific role in the p53 translation initiation process.
Źródło:: Acta Biochimica Polonica; 2016, 63, 4; 645-651
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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