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    Wyświetlanie 1-6 z 6
    Tytuł:
    Regulation of wound-responsive calcium-dependent protein kinase from maize (ZmCPK11) by phosphatidic acid
    Autorzy:
    Klimecka, Maria
    Szczegielniak, Jadwiga
    Godecka, Luiza
    Lewandowska-Gnatowska, Elżbieta
    Dobrowolska, Grażyna
    Muszyńska, Grażyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039858.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Zea mays
    calcium-dependent protein kinases
    abiotic/wound stress signal transduction
    phosphatidic acid
    phospholipids
    Opis:
    In plant cells, phospholipids are not only membrane components but also act as second messengers interacting with various proteins and regulating diverse cellular processes, including stress signal transduction. Here, we report studies on the effects of various phospholipids on the activity and expression of maize wound-responsive calcium-dependent protein kinase (ZmCPK11). Our results revealed that in leaves treated with n-butanol, a potent inhibitor of phosphatidic acid (PA) synthesis catalyzed by phospholipase D, a significant decrease of ZmCPK11 activity was observed, indicating contribution of PA in the kinase activation. Using lipid binding assays, we demonstrate that among various phospholipids only saturated acyl species (16 : 0 and 18 : 0) of phosphatidic acid are able to bind to ZmCPK11. Saturated acyl species of PA are also able to stimulate phosphorylation of exogenous substrates by ZmCPK11 and autophosphorylation of the kinase. The level of ZmCPK11 autophosphorylation is correlated with its enzymatic activity. RT-PCR analysis showed that transcript level of ZmCPK11 in maize leaves increased in response to PA treatment. The influence of PA on the activity and transcript level of ZmCPK11 suggests an involvement of this kinase in a PA-mediated wound signal transduction pathway.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 4; 589-595
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pharmacotherapy of pain in cancer patients – recommendations of the Polish Association for the Study of Pain, Polish Society of Palliative Medicine, Polish Society of Oncology, Polish Society of Family Medicine, Polish Society of Anaesthesiology and Intensive Therapy and Association of Polish Surgeons
    Autorzy:
    Wordliczek, Jerzy
    Kotlińska-Lemieszek, Aleksandra
    Leppert, Wojciech
    Woroń, Jarosław
    Dobrogowski, Jan
    Krajnik, Małgorzata
    Przeklasa-Muszyńska, Anna
    Jassem, Jacek
    Drobnik, Jarosław
    Wrzosek, Anna
    Janecki, Marcin
    Pyszkowska, Jadwiga
    Kocot-Kępska, Magdalena
    Zajączkowska, Renata
    Filipczak-Bryniarska, Iwona
    Boczar, Krystyna
    Jakowicka-Wordliczek, Joanna
    Malec-Milewska, Małgorzata
    Kübler, Andrzej
    Suchorzewski, Marek
    Mordarski, Sylwester
    Dziki, Adam
    Paśnik, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1392429.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    pharmacotherapy
    pain
    cancer patients pain
    recommendations
    oncology
    palliative medicine
    anesthesiology
    adverse effects
    drug interactions
    Opis:
    Guidelines for the pharmacotherapy of pain in cancer patients were developed by a group of 21 experts of the Polish Association for the Study of Pain, Polish Society of Palliative Medicine, Polish Society of Oncology, Polish Society of Family Medicine, Polish Society of Anaesthesiology and Intensive Therapy and Association of Polish Surgeons. During a series of meetings, the experts carried out an overview of the available literature on the treatment of pain in cancer patients, paying particular attention to systematic reviews and more recent randomized studies not included in the reviews. The search was performed in the EMBASE, MEDLINE, and Cochrane Central Register of Controlled Trials databases using such keywords as “pain”, “cancer”, “pharmacotherapy”, “analgesics”, and similar. The overviewed articles included studies of pathomechanisms of pain in cancer patients, methods for the assessment of pain in cancer patients, and drugs used in the pharmacotherapy of pain in cancer patients, including non-opioid analgesics (paracetamol, metamizole, non-steroidal anti-inflammatory drugs), opioids (strong and weak), coanalgesics (glucocorticosteroids, α2-adrenergic receptor agonists, NMDA receptor antagonists, antidepressants, anticonvulsants, topical medications) as well as drugs used to reduce the adverse effects of the analgesic treatment and symptoms other than pain in patients subjected to opioid treatment. The principles of opioid rotation and the management of patients with opioidophobia were discussed and recommendations for the management of opioid-induced hyperalgesia were presented. Drugs used in different types of pain experienced by cancer patients, including neuropathic pain, visceral pain, bone pain, and breakthrough pain, were included in the overview. Most common interactions of drugs used in the pharmacotherapy of pain in cancer patients as well as the principles for the management of crisis situations. In the final part of the recommendations, the issues of pain and care in dying patients are discussed. Recommendations are addressed to physicians of different specialties involved in the diagnostics and treatment of cancer in their daily practice. It is the hope of the experts who took part in the development of these recommendations that the recommendations would become helpful in everyday medical practice and thus contribute to the improvement in the quality of care and the efficacy of pain treatment in this group of patients.
    Źródło:
    Polish Journal of Surgery; 2018, 90, 4; 55-84
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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