Autor: Kaushik, N. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Preferentially Oriented Growth of L1₀ FePt on Si Substrate
Autorzy:: Kaushik, N.
Sharma, P.
Tanaka, S.
Makino, A.
Esashi, M.
Powiązania:: https://bibliotekanauki.pl/articles/1387798.pdf
Data publikacji:: 2015-02
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: 75.20.En
75.50.Ss
75.50.Vv
75.70.Ak
Opis:: Tilting the magnetic easy axis of L1₀ FePt and/or introducing a magnetic buffer layer is most effective in realizing the L1₀ based magnetic recording media. Here we report on preferentially oriented growth of L1₀ FePt with tilted magnetic easy axis. FePt films of thickness up to 170 nm were deposited on Si substrate with a soft magnetic underlayer of glassy FeSiB, FeSiBP and CoFeTaB. Effects of processing conditions on the structural and magnetic properties were studied. A polycrystalline growth of FePt (i.e. mixed orientation) was observed with the underlayer of FeSiB and FeSiBP, but CoFeTaB promotes preferentially oriented growth along (111) crystallographic direction. Compared to FePt films grown on Si substrate, coercivity $(H_{c})$ reduces significantly with the introduction of soft magnetic underlayer. The magnetic easy axis of (111) L1₀ FePt is tilted 36 out of plane and it is very promising for tilted magnetic recording media.
Źródło:: Acta Physica Polonica A; 2015, 127, 2; 611-613
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Drummondin E and Flinderole B are potential inhibitors of RNA-dependent RNA polymerase of SARS-CoV-2: an in silico study
Autorzy:: Akhtar, N.
Verma, H.
Silkari, O.M.
Upadhyay, A.K.
Kaushik, V.
Mannan, M.A.
Powiązania:: https://bibliotekanauki.pl/articles/2096249.pdf
Data publikacji:: 2022
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: RNA polymerase
SARS-CoV-2
RNA-dependent
Drummondin E
Flinderole B
Opis:: Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected 235.6 million people worldwide. In the present study, RNA-dependent RNA polymerase (RdRp) (PDB Id: 6M71) of SARS-CoV-2, an essential enzyme needed for subgenomic replication and amplification of RNA, was selected. Similar to other RdRps, it is a conserved protein and a popular target for antiviral drug therapy. Based on a computational approach, potential RdRp inhibitors were identified. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) of selected molecules were determined using computation tools. The potential inhibitors were docked to the RdRp and later confirmed by Molecular Dynamics (MD) using the “Flare” module of Cresset software. Drummondin E and Flinderole B had higher drug similarity scores among the compounds selected in this study. Both these compounds are noncarcinogenic, nonirritant, nontumorigenic, and nonmutagenic. Molecular docking studies showed that both compounds can bind to RdRp. The best ligand interaction patterns were validated by MD using the “Flare” module. MD was performed for the period of 100 ns with the time step of 1 fs. The simulation results suggest that Thr-680, Arg-624, Lys-676, and Val-557 are key interacting partners in the Drummondin E-RdRp complex, while Asp-618, Asp-760, Asp-623, Arg-624, and Asp-761 are the interacting partners in the Flinderole B-RdRp complex. Based on the in silico drug-likeness score; ADMET properties; and molecular simulation result, we surmise that Flinderole B and Drummondin E could impede SARS-CoV-2 genome replication and transcription by targeting the RdRp protein.
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2022, 103, 1; 53-70
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Synthesis and Characterization of N-Methyl Indole Derivatives via Desulfitative Displacement by Various Amines and Its Antimicrobial Activity
Autorzy:: Chodvadiya, Vijay D.
Pambhar, Kaushik D.
Parmar, Nilesh D.
Dhamsaniya, Ashish P.
Safi, Shahrukh khan A.
Chhatbar, Pratiksha V.
Ram, Hemal N.
Khunt, Ranjan C.
Patel, P. K.
Powiązania:: https://bibliotekanauki.pl/articles/1065130.pdf
Data publikacji:: 2019
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: Anti-microbial agents
Desulfitative displacement
N-methyl indole
S-methyl
Opis:: A modular three step synthetic approach of N-methyl indole derivatives has been carried out by the condensation of N-methyl indole with cyanoacetic acid using acetic anhydride as solvent to yield 3-cyanoacetyl N-methyl indole, which further reacts with carbon disulphide and methyl iodide in basic condition to obtain 2-(1-methyl-1H-indole-3-carbonyl)-3,3-bis(methylthio)acrylonitrile as a scaffold. Subsequent, the scaffold when reacts with substituted various amine derivatives via desulfitative displacement forms new derivatives of 3-((substitutedphenyl)amino)-2-(1-methyl-1H-indole-3-carbonyl)-3-(methylthio)acrylonitrile in moderate to good yields. All the novel compounds were evaluated for their antimicrobial activity against Gram+ve and Gram-ve bacteria and different fungal species which demonstrated well to moderate antimicrobial activity.
Źródło:: World Scientific News; 2019, 120, 2; 181-191
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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