Autor: Grynkiewicz, Grzegorz - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Curcumin and curcuminoids in quest for medicinal status
Autorzy:: Grynkiewicz, Grzegorz
Ślifirski, Piotr
Powiązania:: https://bibliotekanauki.pl/articles/1039733.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: turmeric
oleoresin
curcumin derivatives and analogs
curcuminoids
diferuloylmethane
Michael acceptors
curcumin
Opis:: Curcumin, known for thousands of years as an Ayurvedic medicine, and popular as a spice in Asian cuisine, has undergone in recent times remarkable transformation into a drug candidate with prospective multipotent therapeutic applications. Characterized by high chemical reactivity, resulting from an extended conjugated double bond system prone to nucleophilic attack, curcumin has been shown to interact with a plethora of molecular targets, in numerous experimental observations based on spectral, physicochemical or biological principles. The collected preclinical pharmacological data support traditional claims concerning the medicinal potential of curcumin and its congeners but at the same time point to their suboptimal properties in the ADME (absorption, distribution, metabolism and excretion) area.
Źródło:: Acta Biochimica Polonica; 2012, 59, 2; 201-212
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Triterpene sapogenins with oleanene skeleton: chemotypes and biological activities
Autorzy:: Jatczak, Kamil
Grynkiewicz, Grzegorz
Powiązania:: https://bibliotekanauki.pl/articles/1039280.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: pentacyclic triterpenes
oleanane derivatives
oleanolic acid exploratory chemistry and experimental pharmacology
Opis:: Critical survey of a selected class of pentacyclic triterpenes - the oleanane family, is presented based on current literature in order to underline their value for medicinal chemistry and drug development potential. Oleanenes may be considered as a renewable resource of valuable research materials which are structurally diverse, inherently biocompatible and have built-in affinity for many categories of functional proteins. Although availability of particular compounds from natural sources may be very low, synthetic methods elaborated by generations of chemists, secure a way to obtaining desirable structures from commercial starting materials.
Źródło:: Acta Biochimica Polonica; 2014, 61, 2; 227-243
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 3.

Tytuł:: Synthetic derivatives of genistein, their properties and possible applications
Autorzy:: Rusin, Aleksandra
Krawczyk, Zdzisław
Grynkiewicz, Grzegorz
Gogler, Agnieszka
Zawisza-Puchałka, Jadwiga
Szeja, Wiesław
Powiązania:: https://bibliotekanauki.pl/articles/1040415.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: synthetic genistein derivatives
inhibition of cell proliferation
tyrosine kinases
selective estrogen receptor modulators
anticancer activity
antimicrobial activity
Opis:: Genistein, the principal isoflavone constituent of soybean, attracts much attention as a natural molecule with significant affinity towards targets of potential medicinal interest, but also as a food supplement or prospective chemopreventive agent. Since its physicochemical properties are considered suboptimal for drug development, much effort has been invested in designing its analogs and conjugates in hope to obtain compounds with improved efficacy and selectivity. The aim of this article is to summarize current knowledge about the properties of synthetic genistein derivatives and to discuss possible clinical application of selected novel compounds. Some basic information concerning chemical reactivity of genistein, relevant to the synthesis of its derivatives, is also presented.
Źródło:: Acta Biochimica Polonica; 2010, 57, 1; 23-34
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

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