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    Wyświetlanie 1-11 z 11
    Tytuł:
    Współistnienie nadciśnienia tętniczego z zaburzeniami gospodarki lipidowej wśród żołnierzy zawodowych Warszawskiego Okręgu Wojskowego
    Autorzy:
    Grabysa, Radosław.
    Powiązania:
    Lekarz Wojskowy 1998, nr 1/2, s. [14]-21
    Data publikacji:
    1998
    Tematy:
    Warszawski Okręg Wojskowy kadry choroby
    Nadciśnienie tętnicze
    Choroba niedokrwienna serca
    Opis:
    tab.; Tytuł także w jęz. angielskim; bibliogr.; Streszcz., Sum.
    Dostawca treści:
    Bibliografia CBW
    Artykuł
    Tytuł:
    Cardiovascular complications during the treatment of castration-resistant prostate cancer with the use of modern antiandrogens: abiraterone acetate and enzalutamide
    Autorzy:
    Grabysa, Radosław
    Chmielewska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/2047222.pdf
    Data publikacji:
    2021-09-13
    Wydawca:
    Medical Education
    Tematy:
    abiraterone acetate
    enzalutamide
    castration resistant prostate cancer
    cardiovascular
    Opis:
    Modern antiandrogens: abiraterone acetate (inhibitor of CYP17 cytochrome) and enzalutamide (irreversible inhibitor of androgen receptor) are the drugs that are increasingly often administered in treatment of castration-resistant prostate cancer. Despite their clinical efficacy, especially in terms of prolonged survival and improved quality of life of patients, they pose of problem for a practicing oncologist such as possible cardiovascular complications (particularly arterial hypertension), which may lead to the cessation of this form of therapy. This article provides a brief overview of the mechanisms responsible for the above complications, including practical recommendations in the event such complications arise. A simple scheme of action for control of cardiovascular risk factors has been presented, which can improve the prognosis in this population of patients.
    Źródło:
    OncoReview; 2021, 11, 3; 61-67
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cardiotoxicity of antiangiogenic drugs: causes and mechanisms
    Autorzy:
    Tomaszewska, Beata
    Muzolf, Małgorzata
    Grabysa, Radosław
    Bodnar, Lubomir
    Powiązania:
    https://bibliotekanauki.pl/articles/2047203.pdf
    Data publikacji:
    2021-03-30
    Wydawca:
    Medical Education
    Tematy:
    antiangiogenic agents
    bevacizumab
    cardiooncology
    sorafenib
    sunitinib
    Opis:
    Therapy with angiogenesis inhibitors is undoubtedly an advancement in cancer treatment; however, it is associated with a risk of developing cardiotoxicity, which most often manifests in myocardial contractile dysfunction or an increased risk of thromboembolic events. Heart failure is observed in 2–4% of patients treated with bevacizumab and in 3–8% of patients on antiangiogenic tyrosine kinase inhibitors. The proposed pathomechanisms underlying the impairment in systolic function during antiangiogenic drug treatment include mitochondrial dysfunction, a secondary reduction in cardiomyocyte ATP production and redox imbalance, which may contribute to pathological states known as “free radical diseases”. Additionally, therapy with angiogenesis inhibitors may also cause cardiac oxidative stress. The risk factors for cardiac complications include arterial hypertension, which is a known “class effect” of this class of drugs, as well as a number of other factors such as age, comorbidities, prior radiotherapy and baseline left ventricular ejection fraction. The cardiovascular diseases are still the first cause of death in the world. The more effective oncological treatment becomes, the more often comorbidities occur. This fact seems to demand interdisciplinary approach from investigators and practitioners. This article presents the current state of knowledge on the molecular mechanisms of cardiotoxicity of antiangiogenic drugs used in routine clinical practice.
    Źródło:
    OncoReview; 2021, 11, 1; 12-17
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Thrombosis of the deep dorsal penile vein and corpora cavernosa of the penis as the first symptoms of colon cancer. Case report and literature review
    Autorzy:
    Roslan, Marek
    Przudzik, Maciej
    Borowik, Michał
    Wronka, Henryk
    Kozielec, Zygmunt
    Michalak, Maciej
    Grabysa, Radosław
    Powiązania:
    https://bibliotekanauki.pl/articles/1035859.pdf
    Data publikacji:
    2020-11-17
    Wydawca:
    Medical Education
    Tematy:
    corpus cavernosus thrombosis
    deep dorsal penile vein thrombosis
    metastatic colorectal cancer
    Opis:
    The case describes an 86-year-old man with thrombosis of the deep dorsal vein and corpora cavernosa of the penis who developed symptoms 4 months before hospitalisation. An accurate imaging diagnostics supplemented with a biopsy of the corpus cavernosum confirmed the initial diagnosis. Moreover, an adenocarcinoma of the hepatic flexion of the colon with numerous metastatic lesions, including those to the crus of penis were found. Diagnostic and therapeutic difficulties were described and the results obtained were discussed in the context of available literature.
    Źródło:
    OncoReview; 2020, 10, 3; 98-102
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Endoscopic ultrasound for differential diagnosis of malignant pancreatic cystic lesions: case report and review of literature
    Autorzy:
    Janiszewski, Jacek
    Woźniak, Joanna
    Kot-Gromuł, Iwona
    Michalak, Maciej
    Kozielec, Zygmunt
    Zadrożny, Dariusz
    Grabysa, Radosław
    Powiązania:
    https://bibliotekanauki.pl/articles/1035923.pdf
    Data publikacji:
    2020-11-05
    Wydawca:
    Medical Education
    Tematy:
    endoscopic ultrasound-guided fine-needle aspiration biopsy
    mucinous cystic neoplasm
    pancreatic cancer
    Opis:
    A 63-year-old female patient was admitted to the hospital for an in-depth diagnosis of accidentally found pancreatic cystic lesion. The lesion was detected by computed tomography scan and magnetic resonance imaging of the abdomen and identified as potentially malignant mucinous cystic neoplasm (MCN). Endoscopic ultrasound-guided fine-needle aspiration biopsy with the analysis of the fluid from the cyst was performed as well and it confirmed the malignancy of the cystic lesion. The patient was qualified for surgery and the final diagnosis based on histopathological examination of the surgical material confirmed MCN with the accompanying invasive pancreatic adenocarcinoma.
    Źródło:
    OncoReview; 2020, 10, 3; 103-107
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Laparoscopic nephron sparing surgery on a patient with extreme body deformation due to cerebral palsy. Is this justified when the tumor biopsy is unavailable?
    Autorzy:
    Łesiów, Mirosław
    Borowik, Michał
    Liss, Robert
    Przudzik, Maciej
    Łesiów, Roman
    Grabysa, Radosław
    Michalak, Maciej
    Roslan, Marek
    Powiązania:
    https://bibliotekanauki.pl/articles/2047811.pdf
    Data publikacji:
    2022-03-31
    Wydawca:
    Medical Education
    Tematy:
    cerebral palsy
    kidney cancer
    laparoscopy
    nephron sparing surgery
    Opis:
    Abdominal surgery on patients with significant body malformation is often a challenge for an operative team. Particularly, when patient presents lesions suspected for malignancy but benign disease cannot be excluded. In the reported case the patient suffered from cerebral palsy and had extreme spinal distortion with significant displacement of internal organs. Solid renal mass was detected incidentally, but because of body deformation the biopsy to asses pathological status could not be performed. The decision to perform surgery was made and the patient underwent successful laparoscopic partial nephrectomy. Pathology examination of the specimen revealed renal cell carcinoma grade 2.
    Źródło:
    OncoReview; 2022, 12, 1; 16-19
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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