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    Wyświetlanie 1-2 z 2
    Tytuł:
    Reptiles diversity in Dimapur of North East India
    Autorzy:
    Yanthungbeni, Margret
    Kwabamli, Kwabamli
    Hemsu, H.
    Phom, Lily
    Phom, M. Meyuchila
    Yanthan, Rollen
    Vijila, Vincy
    Nandakumar, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/1158637.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    District Dimapur
    Reptile
    diversity Naga tribal
    Opis:
    The goal of this research is to collect and identify the specimens of reptiles that are found in and around Dimapur, Nagaland. As per the research the data on 12 specimens were collected belonging to snakes, lizards and tortoise. The research highlights the diversity and variety of the types of reptiles present in the Nagaland, and also the possibility of discovering many more. We strongly require intensive studies to document reptiles and other biota of the state. Conservation of biodiversity involving local communities would be the best possible option in Nagaland, as the forest area are largely owned by people. Geochelone elegans (Schoepff, 1795), Python molurus (Linnaeus, 1758), Python binittatus (Kuhl, 1820) and Cuora amboinesis (Daudin, 1802), a total of three species reported from the study area were found to be declared threatened by IUCN 3.1.
    Źródło:
    World Scientific News; 2018, 114; 164-176
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Relative profiling of L-tryptophan derivatives from selected edible mushrooms as psychoactive nutraceuticals to inhibit P-glycoprotein: a paradigm to contest blood-brain barrier
    Autorzy:
    Margret, A.A.
    Mareeswari, R.
    Kumar, K.A.
    Jerley, A.A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096367.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    depression
    blood-brain barrier
    mushrooms
    L-tryptophan
    psychoactive nutraceuticals
    permeability
    glycoprotein
    Opis:
    Depression is a mental illness and is considered to be a global threat. It is designated as burden of disease. There is therefore an intense need to improve the therapeutic response of antidepressants. India beholds a wide fraction (Agaricus bisporus and Pleurotus ostreatus ) as a vital source of non-hallucinogenic indole compounds. The amino acids L-tryptophan and 5-hydroxytryptophan (5-HTP) are precursors of serotonin. 5-HTP is a potential antidepressant that can cross the blood-brain barrier (BBB) at a high rate and is converted into serotonin more efficiently. Drug delivery across this blockade remains a challenge due to the stimulation of efflux pump receptors called permeability glycoprotein (P-gp). This work reports a comparative phytochemical assay and profiling of nonhallucinogenic tryptophan metabolites using HPLC from two organic extracts of edible mushrooms. The efficacy of the eluted compounds was authenticated as P-gp inhibitors with in vitro and in silico studies. The following four derivatives were obtained from the methanol and ethanol extracts of the mushrooms: 5-hydroxy-L-tryptophan (5HTR), 5-hydroxy tryptamine (5-HT), L-tryptophan (L-Trp), and tryptamine (TA). In vitro and molecular docking studies targeting P-gp (minimum energy: -64.38 and -83.93 kcal/mol, respectively) substantiated the ability of mushroom-derived metabolites to facilitate drug delivery in the brain. This study verified that mushrooms containing non-hallucinogenic metabolites can act as psychoactive nutraceuticals that are significant for enhancing mental health. The high therapeutic efficacy, these mushrooms can serve as ideal neurological drug leads to fortify treatment for mental illness.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 1; 55-64
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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