- Tytuł:
-
Nowe substancje psychoaktywne : katynon i jego pochodne
New psychoactive substances : cathinone and its derivatives - Autorzy:
-
Kurpet, Katarzyna
Chwatko, Grażyna - Powiązania:
- https://bibliotekanauki.pl/articles/172450.pdf
- Data publikacji:
- 2019
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
katynon
alkaloidy
narkotyki
czuwaliczka jadalna
nowe substancje psychoaktywne
dopalacze
cathinone
alcaloids
drugs
khat
new psychoactive substances
designer drugs - Opis:
- Cathinone is the major alkaloid found in the Catha edulis plant. The chemical structure of the cathinone is similar to amphetamine, and the difference in their structure is the presence of the ketone group in the beta side chain position. Synthetic derivatives belong to the novel group of psychoactive substances called “legal highs” or designer drugs. Synthetic cathinones are formed by modifications of the cathinone molecule consisting in the attachment of various substituents to the benzene ring and side chain and the use of a nitrogen atom to build the pyrrolidine ring. On this basis, these relationships can be divided into four main groups: N-alkylated, N-pyrrolidinyl, 3,4-methylenedioxy-N-alkylated and 3,4- methylenedioxy-N-pyrrolidinyl derivatives [1-2]. The simplicity of the synthesis and the availability of substrates favors the continuous process of modifying the cathinone derivatives covered by legal control. Therefore, continuous improvement of cathinone detection methods is extremely important for forensic chemistry. Cathinones easily penetrate the blood-brain barrier, inhibiting the uptake of neurotransmitters, including dopamine, serotonin or noradrenaline, and increase their concentration in the synaptic cleft. This leads to increased monoaminergic transmission in the central as well as in the peripheral nervous system, which entails a number of adverse effects [3]. In this article we described the pharmacokinetics, postulated neurochemical mechanisms and pharmacological and toxicological effects of cathinones. The current legal status of cathinone derivatives and selected synthesis methods was also discussed. We believe these information contribute improving public health and safety.
- Źródło:
-
Wiadomości Chemiczne; 2019, 73, 7-8; 461-489
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł