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    Wyświetlanie 1-4 z 4
    Tytuł:
    Study on the mechanical properties of a type of spherical bearing
    Autorzy:
    Yang, Yingfang
    Zhang, Yan
    Ju, Jinsan
    Powiązania:
    https://bibliotekanauki.pl/articles/2055061.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
    Tematy:
    spherical bearing
    finite element
    mechanical properties
    face contact
    Opis:
    The spherical bearing is widely used in highways, bridges and long-span structures. In order to study mechanical properties of a large-scale spherical bearing, a full-scale finite element model of the spherical bearing was established by using ABAQUS software, and the mechanical properties of the spherical bearing under four working conditions were simulated respectively when the upper bearing plate had different inclination angles. The ultimate bearing capacity of the spherical bearing under vertical tension was analyzed emphatically. The research results show that, in practical applications, the change in bearing capacity caused by the inclination angle of the upper bearing plate should be considered, and the wedge-shaped part should be strengthened.
    Źródło:
    Journal of Theoretical and Applied Mechanics; 2021, 59, 4; 539--550
    1429-2955
    Pojawia się w:
    Journal of Theoretical and Applied Mechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    pVAX1 plasmid vector-mediated gene transfer of soluble TRAIL suppresses human hepatocellular carcinoma growth in nude mice
    Autorzy:
    Zhang, Yan
    Ma, Cun
    Liu, Hua
    Zhang, Xiu
    Sun, Wen
    Powiązania:
    https://bibliotekanauki.pl/articles/1041078.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    pVAX1
    soluble TRAIL
    naked DNA
    gene therapy
    hepatocellular carcinoma
    Opis:
    The extracellular domain of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may function as a soluble cytokine to selectively kill various cancer cells without toxicity to most normal cells. We used a high-biosafety plasmid pVAX1 as a vector and constructed a recombinant plasmid expressing the extracellular domain (95-281 aa) of human TRAIL fused with signal peptides of human IgGγ, designated as pVAX-sT. Transduction of human BEL7402 liver cancer cells with pVAX-sT led to high levels of sTRAIL protein in the cell culture media and induced apoptosis. The therapeutic potential of pVAX-sT was then evaluated in the BEL7402 transplanted naked mouse model. Subsequent intratumoral administration of naked pVAX-sT resulted in the expression of soluble TRAIL in the sera and the tumor site, as well as effective suppression of tumor growth, with no toxicity to liver. In conclusion, the successful inhibition of liver cancer growth and the absence of detectable toxicity suggest that pVAX-sT could be useful in the gene therapy of liver cancer.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 2; 307-313
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of Metal Oxides on the Thermal Decomposition Kinetics and Mechanisms of HAN/PVA Based Propellants
    Autorzy:
    Hu, Song-qi
    Liu, Xue-li
    Liu, Lin-Lin
    Kang, Bo
    Zhang, Yan
    Powiązania:
    https://bibliotekanauki.pl/articles/27787991.pdf
    Data publikacji:
    2021
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    HAN/PVA-based propellant
    metal oxides
    catalytic behaviour
    kinetic parameters
    Opis:
    The thermal decomposition processes of HAN/PVA-based propellants have been investigated using a simultaneous thermogravimetric analysis (TGA) – differential scanning calorimetry (DSC), coupled with Fourier-Transform Infrared Spectroscopy (FTIR) and Mass Spectrometry (MS) system. The activation energy (Ea), pre-exponential factor A and reaction mechanism function f(α) of the decomposition processes have been determined by non-isothermal and Malek methods. The results showed that the decomposition process of an HAN/PVA sample occurs mainly in the temperature range 202.2~220.1 °C, with a mass loss, heat release and Ea of about 84.8%, 1474.18 and 88.76 kJ·mol–1, respectively. Of the seven metal oxides studied as catalysts, Al2O3, V2O5 and Fe2O3 have significant catalytic effects on an HAN/PVA-based propellant, in lowering the decomposition temperature, with Ea changing from 88.8 to 83.7, 85.6 and 113.6 kJ·mol–1, respectively. The f(α) of both HAN/PVA and HAN/PVA/Al2O3 samples can be expressed as f(α) = (1 – α)2, whereas f(α) = α or f(α) = α/2 fit well for the HAN/PVA/V2O5 and HAN/PVA/Fe2O3 samples.
    Źródło:
    Central European Journal of Energetic Materials; 2021, 18, 3; 322-338
    1733-7178
    Pojawia się w:
    Central European Journal of Energetic Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Two Gln187 mutants of human soluble APRIL inhibit proliferation of lung carcinoma A549 cells
    Autorzy:
    Dai, Shuangshuang
    Zheng, Yingru
    Chen, Bin
    Gao, Min
    Zhang, Yan
    Zhang, Li
    Gong, Wei
    He, Fengtain
    Powiązania:
    https://bibliotekanauki.pl/articles/1040492.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    APRIL
    Gln187 mutant of sAPRIL
    anti-tumor activity
    Opis:
    Soluble APRIL (sAPRIL), the active form of a proliferation-inducing ligand (APRIL), is implicated in the proliferation of tumor cells. Suppressing APRIL function has been considered as a potential strategy for the therapy of APRIL-associated tumors. In the present study, we generated human sAPRIL and its two mutants, Gln187-D-sAPRIL (Gln187 deleted) and Gly187-sAPRIL (Gln187 replaced by Gly). In vitro experiments showed that the two mutants had similar specific binding capacity to lung carcinoma A549 cells compared to the wild-type sAPRIL, and both, especially Gly187-sAPRIL, exhibited significant antagonistic effect on sAPRIL-induced tumor cell proliferation in a dose-dependent manner, which might be predominantly mediated by blocking sAPRIL-induced MEK and ERK phosphorylation but not p38MAPK or JNK signaling. In vivo experiments with nude mice bearing A549 cell-derived xenograft tumor showed that only the Gly187-sAPRIL mutant could significantly suppress the tumor growth. These results suggest that Gln187 may be a crucial amino acid in APRIL-mediated tumor cell proliferation via the MEK-ERK signaling pathway and that the sAPRIL mutants may serve as novel potential antagonists of APRIL for the therapy of APRIL-associated cancers.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 4; 703-710
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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