- Tytuł:
- Chelating ability of proctolin tetrazole analogue
- Autorzy:
-
Łodyga-Chruścińska, Elżbieta
Sanna, Daniele
Micera, Giovanni
Chruściński, Longin
Olejnik, Jadwiga
Nachman, Ronald
Zabrocki, Janusz - Powiązania:
- https://bibliotekanauki.pl/articles/1041268.pdf
- Data publikacji:
- 2006
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
metallopeptides
metal complexes
proctolin
tetrazole peptide analogue - Opis:
- The aim of the investigation was to establish the chelating ability of a new proctolin analogue of the sequence Arg-Tyr-LeuΨ[CN4]Ala-Thr towards copper(II) ions. The insertion of the tetrazole moiety into the peptide sequence has considerably changed the coordination ability of the ligand. Potentiometric and spectroscopic (UV-Vis, CD, EPR) results indicate that the incorporation of 1,5-disubstituted tetrazole ring favours the formation of a stable complex form of CuH-1L. This 4N coordination type complex is the dominant species in the physiological pH range. The tetrazole moiety provides one of these nitrogens. The data indicate that Cu(II) ions are strongly trapped inside the peptide backbone. These findings suggest that Cu(II) can hold peptide chains in a bent conformation. This bent conformation may be essential for bioactivity of the tetrazole peptides.
- Źródło:
-
Acta Biochimica Polonica; 2006, 53, 1; 65-72
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł