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    Tytuł:
    Produkcyjność maciorek wschodnio-fryzyjskich i ich potomstwa F1 po merynosie polskim i owcy wielkopolskiej
    Produktivnost' vostochno-frizsrikh ovcematok i ikh potomstva F1 posle pol'skogo merinosa i vel'skopol'skoj ovcy
    Productivity of East-Friesian ewes and of the F1 progeny after the Polish Merino ram and Wielkopolska ewe
    Autorzy:
    Wojtkowski, J.
    Gut, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/799949.pdf
    Data publikacji:
    1988
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Tematy:
    hodowla zwierzat
    genetyka zwierzat
    owce
    rasy zwierzat
    owca wschodniofryzyjska
    owca merynos polski
    owca wielkopolska
    maciorki
    produkcyjnosc zwierzat
    linie hodowlane
    cechy uzytkowe
    animal breeding
    animal genetics
    sheep
    productivity
    animal productivity
    ewe
    East-Friesian breed
    F1 population
    Polish Merino breed
    ram
    Wielkopolska breed
    breeding line
    body weight
    Opis:
    Исследовали восточно-фризские овцематки молочного типа и их женское потомство F₁ после польских мериносовых баранов и вельскопольской овцы. Восточно-фризские овцематки достигали очень высокого уровня шерстной продуктивности и высокой массы тела, а их репродуктивность была выше, чем у овец этой породы содержимых в условиях стадного разведения. Овцы-помеси, особенно после велькопольских баранов, характеризовались высоким уровнем продукции чистого волокна, высоким весом тела и удовлетворительной оплодотворимостью. Сравнение продуктивности одной и другой группы неселекционированных помесей с отвечающими им (отцовская порода) овцематками польского мериноса и велькопольской овцы указывает на пригодность этих животных к выгеьению синтетической оплотворительно-щерстистой линии овец.
    East-Friesian ewes of the meat-type sheep and their feminine F₁ progeny after the Polish Merino rams and Wielkopolska ewes were tested.The experimental material constituted Polish Merino and Wielkopolska ewes. The East-Friesian ewes reached a very high level of the wool performance and a high body weight and their reproductive utilization was higher than in sheep of the same breed maintained irder flock rearing conditions. Crosses, particularly after Wielkopolska rams, distinguished themselves with a high pure fibre production level, high body weight and satisfactory fecundity. The comparison of the productivity of that and other group of nonselectioned crosses with Polish Merino ewes (paternal breed) and Wielkopolska ewes proved a suitability of these animals for breeding a synthetic reproduction and wool performance line of sheep.
    Źródło:
    Zeszyty Problemowe Postępów Nauk Rolniczych; 1988, 352
    0084-5477
    Pojawia się w:
    Zeszyty Problemowe Postępów Nauk Rolniczych
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of granulocyte colony-stimulating factor therapy for osteogenesis imperfecta: a case report
    Autorzy:
    Paszko-Patej, G.
    Sienkiewicz, D.
    Kułak, W.
    Okurowska-Zawada, B.
    Wojtkowski, J.
    Kalinowska, A.
    Okulczyk, K.
    Sochoń, K.
    Dmitruk, E.
    Mirska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918408.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Osteogenesis imperfecta
    granulocyte colony-stimulating factor
    muscle strength
    Opis:
    Introduction: Osteogenesis imperfecta (OI) is a genetic disorder of increased bone fragility and low bone mass. OI type IV. Materials and methods: We examined the safety and effectiveness of a low dose of analog granulocyte colony-stimulating factor (G-CSF) in a 15-year-old girl OI type IV. G-CSF 5 μg/kg was given subcutaneously, for 5 days/month for 3, 6 and 12 months. Laboratory tests, including blood, biochemical tests were performed, in addition to clinical examination.Results: Clinical examination revealed an increase of muscle strength in the upper and lower limbs between base line and day 6 and 12 months. We found no serious adverse events. Leukocyte levels remained below 38,000/μL. Low dose G-CSF was safe and well tolerated by the patient. Conclusions: A significant increase in muscle strength in this patient may indicate beneficial effects of G-CSF factor in this disorder. These results are inspiring and warrant further studies.
    Źródło:
    Progress in Health Sciences; 2017, 7(1); 205-208
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of granulocyte colony-stimulating factor treatment in children and patients with cerebral palsy: a preliminary report
    Autorzy:
    Paszko-Patej, G.
    Kułak, W.
    Okurowska-Zawada, B.
    Sienkiewicz, D.
    Wojtkowski, J.
    Sochoń, K.
    Kalinowska, A.
    Okulczyk, K.
    Topór, E.
    Mirska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918403.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Granulocyte colony-stimulating factor
    children
    cerebral palsy
    Opis:
    Introduction: Recent reports have revealed that neuroinflammation and apoptosis in brains affected by cerebral palsy could be therapeutic targets. Granulocyte colony-stimulating factor (G-CSF) exerts anti-inflammatory and antiapoptosis effects and stimulates the proliferation of neural stem and progenitor cells in the brain. Purpose: To assess the efficacy and safety of G-CSF treatment in children and adolescents with CP. Materials and methods: Six patients with spastic tetraplegia CP aged 3-15 years were enrolled in this study. Five patients had GMFCS (Gross Motor Function Classification System) level at V, three children had epilepsy, and three had severe mental retardation. We used the gross motor function measure-66 (GMFM-66) to assess motor function.GCSF (5μg/kg/body/day) was administered subcutaneously for five consecutive days during the four months. The parents also evaluated the physical and mental development of their children. Results: We observed improvement in motor function in patients with CP on the GMFM-66 scale. Parents reported improvement in behavior, speech development, and a decrease in spasticity in children with CP. G-CSF therapy was well-tolerated. No side effects were observed during the study. Conclusions: Our preliminary report suggests that G-CSF treatment improves motor and mental function in patients with CP. Further studies are needed to confirm these observations
    Źródło:
    Progress in Health Sciences; 2017, 7(1); 78-82
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Quality of life of children suffering from motor disabilities as evaluated by their parents
    Autorzy:
    Wojtkowski, J.
    Sienkiewicz, D.
    Okurowska-Zawada, B.
    Paszko-Patej, G.
    Konopka, A.
    Okulczyk, K.
    Średzińska, K.
    Dmitruk, E.
    Mirska, A.
    Kułak, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918580.pdf
    Data publikacji:
    2018-01-09
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Quality of life
    motor disability
    children
    parents
    Opis:
    Purpose: We assessed the quality of life of children with motor disabilities in comparison with healthy children, as evaluated by their parents, using the CHQ-PF28 questionnaire (Child Health Questionnaire—Parent Form). Materials and methods: In a prospective study, we evaluated the quality of life of 105 children with motor disabilities. Results: Our research showed lower quality of life in the group of children with motor disabilities compared with controls, both in terms of physical and psychosocial health. Significant correlations between independent walking and physical functioning, general behavior, and mental health of children suffering from motor disabilities were found. According to the average indices of quality of life of children suffering from motor disabilities, depending on sex, the greatest differences occurred in behavior and change of health status, while the smallest differences in self-esteem and parental involvement, compared with controls. In the case of healthy children, the largest differences appeared in the perception of pain, behavior, and self-esteem; whereas, the smallest variations occurred in the change of health status and physical activity. Conclusion: Children suffering from motor disabilities demonstrate lower quality of life compared with healthy children.
    Źródło:
    Progress in Health Sciences; 2017, 7(2); 60-66
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Granulocyte colony-stimulating factor therapy for facioscapulohumeral dystrophy: a case report
    Autorzy:
    Sienkiewicz, D.
    Kułak, W.
    Okurowska-Zawada, B.
    Paszko-Patej, G.
    Wojtkowski, J.
    Dmitruk, E.
    Okulczyk, K.
    Sochoń, K.
    Kalinowska, A.
    Żak, J.
    Pogorzelski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918329.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Facioscapulohumeral dystrophy
    granulocyte colony-stimulating factor
    muscle strength
    Opis:
    We examined the safety and effectiveness of a low dose of analog granulocyte-colony stimulating factor in a 15-year-old boy with facioscapulohumeral dystrophy. The onset of disease was noted at 12 years of age. The physical examination noted general muscle atrophy more pronounced at left side of the body. He was able to walk 300 meters within 6 minute walk test. Granulocyte colony-stimulating factor 5 μg/kg was given subcutaneously daily for 5 days/month for 1, 2, 3, 6 and 12 months. Clinical examination, laboratory tests including blood, biochemical tests, and CD34+ cells were performed. A significant increase of muscle strength in the lower and upper limbs between baseline, and after 3 months of treatment, after 6, and after 12 months was found. He was able to walk 480 meters within 6 minutes after 12 months. Electromyography demonstrated increase of amplitude in the examined in upper and lower limbs after six months compared to baseline. Leukocyte levels remained below 25000/μL. CD34+ increased significantly at day 5 of granulocyte colony-stimulating factor admini-stration. It was safe and well tolerated by the patient. A significant increase in muscle strength in this patient with facioscapulohumeral dystrophy after 3 months of treatment, after 6, and after 12 months since the first treatment course was completed may indicate beneficial effects of granulocyte colony-stimulating factor in this disorder.
    Źródło:
    Progress in Health Sciences; 2016, 6(2); 175-177
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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