- Tytuł:
-
Synteza i aktywność biologiczna pochodnych 2,6-naftyrydyny
Synthesis and biological activity of 2,6-nap hthyridine derivatives - Autorzy:
-
Wójcicka, A.
Wagner, E. - Powiązania:
- https://bibliotekanauki.pl/articles/172545.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
pochodne 2,6-naftyrydyny
synteza
aktywność biologiczna
2,6-naphthyridine derivatives
synthesis
biological activity - Opis:
- 2,6-Naphthyridine is one of the six structural isomers of pyridopyridines. This review presents most of the literature data about natural and synthetic 2,6-naphthyridine derivatives and their biological activity. The main goal of this paper is to present various methods for the preparation of 2,6-naphthyridine analogues. Compounds containing 2,6-naphthyridine moiety can be synthesized from different substrates. Most of them have been obtained by cyclocondensation of various pyridine derivatives. During the past twenty years the biological activity of 2,6-naphthyridines have been studied. Presented compounds exhibit anticancer [21, 41], antihypertension [10], and antidepression [25] activity. Some of them can be used in the treatment of heart diseases [22], appetite disturbance, and obsessive states [43, 44]. 2,6-Naphthyridine derivatives with different molecular targets, e.g. topoisomerase [41], SERT [27], and protein kinases [21, 22] inhibitors have also been reported. Many of the 2,6-naphthyridine analogues are histamine H3 [27] and serotonine 5-HT2 [42–44] receptor antagonists.
- Źródło:
-
Wiadomości Chemiczne; 2012, 66, 3-4; 297-318
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł