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Wyświetlanie 1-2 z 2
Tytuł:
Cardiotoxicity of antiangiogenic drugs: causes and mechanisms
Autorzy:
Tomaszewska, Beata
Muzolf, Małgorzata
Grabysa, Radosław
Bodnar, Lubomir
Powiązania:
https://bibliotekanauki.pl/articles/2047203.pdf
Data publikacji:
2021-03-30
Wydawca:
Medical Education
Tematy:
antiangiogenic agents
bevacizumab
cardiooncology
sorafenib
sunitinib
Opis:
Therapy with angiogenesis inhibitors is undoubtedly an advancement in cancer treatment; however, it is associated with a risk of developing cardiotoxicity, which most often manifests in myocardial contractile dysfunction or an increased risk of thromboembolic events. Heart failure is observed in 2–4% of patients treated with bevacizumab and in 3–8% of patients on antiangiogenic tyrosine kinase inhibitors. The proposed pathomechanisms underlying the impairment in systolic function during antiangiogenic drug treatment include mitochondrial dysfunction, a secondary reduction in cardiomyocyte ATP production and redox imbalance, which may contribute to pathological states known as “free radical diseases”. Additionally, therapy with angiogenesis inhibitors may also cause cardiac oxidative stress. The risk factors for cardiac complications include arterial hypertension, which is a known “class effect” of this class of drugs, as well as a number of other factors such as age, comorbidities, prior radiotherapy and baseline left ventricular ejection fraction. The cardiovascular diseases are still the first cause of death in the world. The more effective oncological treatment becomes, the more often comorbidities occur. This fact seems to demand interdisciplinary approach from investigators and practitioners. This article presents the current state of knowledge on the molecular mechanisms of cardiotoxicity of antiangiogenic drugs used in routine clinical practice.
Źródło:
OncoReview; 2021, 11, 1; 12-17
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tematyka geotermalna w aktualnej działalności naukowo-badawczej IGSMiE PAN w latach 2019–2021 i plany na przyszłość
Geothermal topics in the current research activities of MEERI PAS in 2019-2021 and plans for the future
Autorzy:
Bujakowski, Wiesław
Tomaszewska, Beata
Kępińska, Beata
Pająk, Leszek
Bielec, Bogusław
Miecznik, Maciej
Kasztelewicz, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/2076237.pdf
Data publikacji:
2021
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
energia geotermalna
projekty badawcze
woda geotermalna
środowisko społeczne
gospodarka
geothermal energy
research projects
geothermal water
social environment
economy
Opis:
The Mineral and Energy Economy Research Institute of the Polish Academy of Sciences (MEERI PAS) is celebrating its 35th anniversary this year. The Institute was established in 1986on the initiative of Prof. Dr Eng. Roman Ney, who was its first Director. Inspired by Professors Roman Ney and Julian Sokołowski, research on the recognition and use of geothermal energy in Poland was launched at the Institute. A measurable achievement of the research team established in 1993 was the launch of the first geothermal installation in the country, under the name of the Experimental Geothermal Plant Bańska - Biały Dunajec, located in the Podhale region. This prototype installation prompted the establishment of PEC Geotermia Podhalańska S.A. and the inspiration for the construction of further geothermal plants in Poland. Through the period of over 3 0years, the team of scientists associated with the current Division of Renewable Energy Sources of MEERIPAS has developed several hundred works on geothermal issues. These were, among others, documentations ofnew and reconstructed geothermal wells, resource documentations, pre-investment expert reports, articles, monographs, atlases and various scientific presentations, as well as information popularizing geothermal topics. In recent years, 42 research tasks of utilitarian nature, 55 articles and scientific reports of national and international scope, and 9 research projects have been carried out in the Division of Renewable Energy Sources.
Źródło:
Przegląd Geologiczny; 2021, 69, 9; 624--632
0033-2151
Pojawia się w:
Przegląd Geologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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