- Tytuł:
- Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions
- Autorzy:
-
Reiter, Russel
Tan, Dun-xian
Terron, M
Flores, Luis
Czarnocki, Zbigniew - Powiązania:
- https://bibliotekanauki.pl/articles/1041101.pdf
- Data publikacji:
- 2007
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
electron donation
melatonin synthesis
free radicals
antioxidant
oxidative stress - Opis:
- This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methylates N-acetylserotonin to melatonin may be rate-limiting in some cases. Also, the review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals. Finally, the review briefly summarizes the actions of melatonin and its metabolites in the detoxification of oxygen and nitrogen-based free radicals and related non-radical products. Via these multiple processes, melatonin is capable of influencing the metabolism of every cell in the organism.
- Źródło:
-
Acta Biochimica Polonica; 2007, 54, 1; 1-9
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł