- Tytuł:
- Potentiation of adipogenesis and insulinomimetic effects of a novel vanadium complex (N′-[(E)-(5-bromo-2oxophenyl)methylidene]-4methoxybenzohydrazide)oxido(1,10phenanthroline)vanadium(IV) in 3T3-L1 cells
- Autorzy:
-
Kazek, Grzegorz
Głuch-Lutwin, Monika
Mordyl, Barbara
Menaszek, Elżbieta
Szklarzewicz, Janusz
Gryboś, Ryszard
Papież, Monika - Powiązania:
- https://bibliotekanauki.pl/articles/93178.pdf
- Data publikacji:
- 2019
- Wydawca:
- Państwowa Wyższa Szkoła Zawodowa w Tarnowie
- Tematy:
-
vanadium complex
phosphatases inhibition
adipocytes
adipogenesis
glucose utilization
kompleks wanadu
inhibicja fosfataz
adipocyt
adipogeneza
wykorzystanie glukozy - Opis:
- Recent research on the action of vanadium compounds shows its important effect on adipogenesis processes and adipocyte function. On the basis of previous screening tests in cellular models, the novel vanadium complex (N′-[(E)-(5-bromo-2-oxophenyl)methylidene]4-methoxybenzohydrazide)oxido(1,10-phenanthroline)vanadium(IV) was selected for this study. This complex exhibits potent inhibition of tyrosine phosphatases, and differences in the degree of inhibition were observed particularly for phosphatases. A significant increase in intracellular lipid accumulation and proliferative effect on 3T3-L1 preadipocytes confirmed the ability of this complex to enhance adipogenesis. The insulinomimetic activity of the tested complex was also demonstrated in fully differentiated 3T3-L1 adipocytes, in which glucose utilization was potentiated. The obtained results support the hypothesis that vanadium complexes show promising possibilities for use as new therapeutic strategies for the treatment of type 2 diabetes.
- Źródło:
-
Science, Technology and Innovation; 2019, 4, 1; 55-62
2544-9125 - Pojawia się w:
- Science, Technology and Innovation
- Dostawca treści:
- Biblioteka Nauki
Artykuł