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Wyświetlanie 1-5 z 5
Tytuł:
Synchronous occurrence of multiple focal nodular hyperplasia and huge hepatic Perivascular epithelioid cells tumor (PEComa) in young woman after oral contraceptive use – is there a common pathogenesis?
Autorzy:
Durczyński, Adam
Hogendorf, Piotr
Szymański, Dariusz
Sporny, Stanisław
Strzelczyk, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1396820.pdf
Data publikacji:
2012-10-01
Wydawca:
Index Copernicus International
Tematy:
liver
perivascular epithelioid cells tumor
focal nodular hyperplasia
oral contraceptive
Opis:
The association of focal nodular hyperplasia (FNH) and various neoplasms was described, but coincidence of multiple FNH and hepatic perivascular epithelioid cells tumor (PEComa) has not been reported. The clinical debate of oral contraceptive (OC) influence on FNH growth is ongoing, but no evidence exists about association of hepatic PEComa with OC use. Herein, we report a case of two FNH lesions and huge (150x100x80 mm) left hepatic lobe PEComa that occurred simultaneously in 18-year-old female with previous two year history of OC use, who underwent left hemihepatectomy and right hepatic FNH enucleation. Up to date, the patient has been followed-up for 65 months and remained disease-free. FNH and PEComa have a common vascular cytogenetic denominator. Our case raising a question of a causal relationship of FNH and PEComa with OC use that might be attributed to vascular changes. Future researches of larger sample sizes should further address this issue.
Źródło:
Polish Journal of Surgery; 2012, 84, 9; 457-460
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Very High Concentration of D-Dimers in Portal Blood in Patients with Pancreatic Cancer
Autorzy:
Durczyński, Adam
Szymański, Dariusz
Nowicki, Michał
Hogendorf, Piotr
Poznańska, Grażyna
Strzelczyk, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1396873.pdf
Data publikacji:
2012-12-01
Wydawca:
Index Copernicus International
Tematy:
D-dimers
pancreatic cancer
portal blood
peripheral blood
Opis:
Nowadays, increasing attention has been focused on relation between increased D-dimer levels and cancer among patients without detectable thrombosis. The aim of the study was to measure plasma D-dimer levels in portal and peripheral blood in pancreatic cancer patients with absence of venous thromboembolism. Material and methods. Fifteen consecutive patients hospitalized in the Department of General and Transplant Surgery of Medical University in Łódź, from January to March 2012 who underwent surgery due to a pancreatic cancer were enrolled. At laparotomy, portal and peripheral blood were sampled concurrently. D-dimer and fibrinogen levels were measured. Moreover, to investigate overall coagulation function prothrombin time (PT), prothrombin index (PI), international normalized ratio (INR), thrombin time (TT), activated partial thromboplastin time (APTT), TT and APTT index were evaluated. Results. Peripheral plasma D-dimmer levels above normal range were found in 10/15 patients (66,67%), whereas D-dimer above normal values were confirmed in all portal blood samples. Mean D-dimer values were higher in portal than in peripheral blood (3279.37 vs 824.64, by 297%, p=0,025). These discrepancies were accompanied by normal limits of portal and peripheral levels of fibrinogen and comparable coagulation function indexes. Conclusion. Our preliminary study showed the close relation between activation of hemostasis, reflected by elevated D-dimers in portal blood and presence of pancreatic cancer. These data suggest that measurement of portal blood D-dimer levels may be a potentially useful technique for screening the pancreatic cancer.
Źródło:
Polish Journal of Surgery; 2012, 84, 10; 521-525
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Insulinoma - Rare, But Important Clinical Problem. Analysis of a Series of 530 Patients Who Underwent Surgical Treatment for the Pancreatic Tumor
Autorzy:
Durczyński, Adam
Hogendorf, Piotr
Szymański, Dariusz
Izdebski, Witold
Kaczka, Aleksandra
Durko, Łukasz
Strzelczyk, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1395993.pdf
Data publikacji:
2015-02-03
Wydawca:
Index Copernicus International
Tematy:
insulinoma
pancreatic tumor
surgery
Opis:
Insulinomas are rare tumors, accounting for 1-2% of all neoplasms of the pancreas. Usually their treatment is not associated with any problems; however there is a small subset of problematic clinical cases. The authors present their own clinical experience with surgical treatment of insulinomas of the pancreas. The aim of the study was to conduct a retrospective analysis of patients with insulinomas of the pancreas who underwent surgical treatment at Department of General and Transplant Surgery Medical University in Łódź. Material and methods. The study included all patients who underwent surgical treatment at the Department between 2007 and 2013 for the tumor of the pancreas. Further retrospective analysis included all patients with tumors of the insulinoma type. The data was obtained from medical records, surgical protocols and histopathology reports. Results. The analysis included 530 patients who underwent surgical treatment for the tumor of the pancreas. Insulinoma was found in 10 (1.88%) patients (8 females, 2 males). An average age of patients who underwent surgical treatment was 47.5±13.8 years. An average size of the tumor was 1.6±0.5 cm. Six patients underwent extirpation of the insulinoma, while the other patients underwent distal resection of the pancreas. All patients underwent “an open surgical procedure”. The average duration of the surgical procedure was 55±45 minutes. Duration of the hospitalization in the analyzed group of patients was 7±5 days. Incidence of postoperative pancreatic fistulas was 10%. All insulinomas were benign. Conclusions. Insulinomas were rare among patients who underwent surgical treatment at the Department. They were benign and their treatment was unproblematic. However, there is a small group of cases that can be associated with problematic clinical situations. Thus treatment of patients with insulinomas should be conducted at specialist centers. Correct diagnostic and therapeutic management, involving close cooperation between multiple medical specialists, results in complete curing of majority of patients.
Źródło:
Polish Journal of Surgery; 2014, 86, 11; 505-510
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neutrophil-lymphocyte ratio and creatinine reduction ratio predict good early graft function among adult cadaveric donor renal transplant recipients. Single institution series
Autorzy:
Hogendorf, Piotr
Suska, Anna
Skulimowski, Aleksander
Rut, Joanna
Grochowska, Monika
Wencel, Aleksandra
Dziwisz, Filip
Nowicki, Michał
Szymański, Dariusz
Poznańska, Grażyna
Durczyński, Adam
Strzelczyk, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1392878.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
neutrophil-lymphocyte ratio
creatinine reduction ratio
graft function
cadaveric donor
delayed graft function kidney transplant
Opis:
The Background Delayed graft function (DGF) is a common complication following kidney transplantation and is associated with ischemia-reperfusion injury (IRI). Lymphocytes contribute to the pathogenesis of IRI and ischemia-reperfusion related to delayed graft function. Materials and Methods : 135 Caucasian patients received a kidney graft from deceased heart-beating organ donors. We divided patients into 2 groups - patients with the eGFR>=30 on the 21st day post-transplantation (n=36) and patients with the eGFR<30 on the 21st day post-transplantation (n=99) to assess kidney graft function. We measured serum creatinine levels on 1st and 2nd post-transplant day and preoperative levels of monocytes, lymphocytes, platelets, and neutrophils and their ratios. Results: We have found statistically significant differences between the eGFR<30 and the eGFR>=30 groups in the average lnLymphocytes (0.36 +/-0.6 vs. -0.016 +/-0.74, respectively p=0.004) lnNLR (1,27 +/-0.92 vs. 1.73+/-1.08 p=0.016) lnLMR (1.01 +/-0.57 vs. 0.73 +/-0.64 p=0.02), lnPLR (4.97 +/-0.55 vs. 5.26 +/- 0.67 p=0.023), and CCR 2% (-20.20 +/- 21.55 vs. -4.29 +/- 29.62 p=0.004. In the univariate analysis, factors of lnLymphocytes >=0.22 (OR=0.331 95%CI 0.151-0.728 p=0.006), lnLMR>=1.4 (OR=0.255 95%CI 0.072-0.903 p=0.034) were associated with a worse graft function, while lnNLR>=1.05 (OR=2.653 95%CI 1.158-6,078 p=0.021), lnPLR>=5.15 (OR=2.536 95%CI 1.155-5.566 p=0.02) and CRR2 (OR=3.286 95% CI 1.359-7.944 p=0.008) indicated a better graft function. Conclusion: A higher absolute lymphocyte count (lnLymphocytes) and lnLMR, as well as lower lnNLR and lnPLR were associated with a lower eGFR on the 21st day after kidney transplantation. In the multivariate analysis, CRR2 in combination with either lnLymphocytes, lnNLR or lnPLR improved the accuracy of detecting patients with poor graft function.
Źródło:
Polish Journal of Surgery; 2018, 90, 2; 28-33
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stosunek liczby neutrofilów do limfocytów oraz wskaźnik redukcji kreatyniny pozwalają na przewidzenie dobrej wczesnej czynności przeszczepu nerki u dorosłych
Autorzy:
Hogendorf, Piotr
Suska, Anna
Skulimowski, Aleksander
Rut, Joanna
Grochowska, Monika
Wencel, Aleksandra
Dziwisz, Filip
Nowicki, Michał
Szymański, Dariusz
Poznańska, Grażyna
Durczyński, Adam
Strzelczyk, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1392885.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
neutrophil-lymphocyte ratio
creatinine reduction ratio
graft function
cadaveric donor
delayed graft function kidney transplant
Opis:
Opóźniona funkcja nerki przeszczepionej (DGF) jest częstym powikłaniem po transplantacji nerki. Jest związana z uszkodzeniem niedokrwienno-reperfuzyjnym (IRI). Do patogenezy uszkodzenia niedokrwienno-reperfuzyjnego związanego z opóźnioną funkcją przeszczepu przyczyniają się limfocyty. Materiał i metody: 135 pacjentów rasy kaukaskiej otrzymało przeszczep nerki od zmarłych dawców z bijącym sercem. W celu oceny funkcji przeszczepu pacjenci zostali podzieleni na dwie grupy – pacjentów z eGFR30 w 21. dniu po przeszczepieniu (n = 36) oraz pacjentów z eGFR <30 w 21. dniu po przeszczepieniu (n = 99). Zmierzony został poziomy kreatyniny w surowicy w 1. oraz 2. dniu po przeszczepie oraz przedoperacyjne ilość monocytów, limfocytów, płytek krwi i neutrofilów, jak również proporcje pomiędzy nimi. Wyniki: Stwierdzono statystycznie istotne różnice między grupami eGFR <30 i eGFR 30 w ilości limfocytów (0,36 +/- 0,6 vs -0,016 +/- 0,74; odpowiednio p = 0,004) lnNLR (stosunek neutrofili do limfocytów) (1,27 +/- 0,92 vs 1,73 +/- 1,08; p = 0,016) lnLMR (stosunek limfocytów do monocytów) (1,01 +/- 0,57 vs 0,73 +/- 0,64; p = 0,02), lnPLR (stosunek płytek do limfocytów) (4,97 +/- 0,55 vs 5,26 +/- 0,67; p = 0,023), i CCR 2% (-20,20 +/- 21,55 vs -4,29 +/- 29,62; p = 0,004). W analizie jednowymiarowej, czynniki, takie jak: ilość limfocytów 0,22 (OR = 0,331; 95% CI 0,151–0,728; p = 0,006), LnLMR1,4 (OR = 0,255; 95% CI 0,072–0,903; p = 0,034) były związane z gorszą funkcją przeszczepu, podczas gdy lnNLR 1,05 (OR = 2,653 95% CI 1,1158–6,078; p = 0,021), lnPLR 5,15 (OR = 2,536; 95% CI 1,155–5,566; p = 0,02) i CRR2 (współczynnik redukcji kreatyniny w drugim dniu) (OR = 3,286; 95% CI 1,359 –7,944; p = 0,008) wskazywało na lepszą funkcję przeszczepu. Podsumowanie: Wyższa bezwzględna liczba limfocytów (lnLymphocytes) i lnLMR, a także niższy poziom lnNLR i lnPLR były związane z niższym eGFR w 21. dniu po przeszczepie nerki. W analizie wieloczynnikowej CRR2 w połączeniu z limfocytami lnNLR lub lnPLR umożliwiły wyższą dokładność w identyfikacji pacjentów z nieprawidłową funkcją przeszczepu.
Źródło:
Polish Journal of Surgery; 2018, 90, 2; 28-33
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-5 z 5

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