Autor: Sokołowska, J. J. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Survivin expression in correlation with apoptotic activity in canine lymphomas
Autorzy:: Sokolowska, J.
Urbanska, K.
Powiązania:: https://bibliotekanauki.pl/articles/32259.pdf
Data publikacji:: 2017
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Survivin regulates cell cycle and mitosis and has antiapoptotic properties. Because of its dual function survivin has been the subject of much research focusing on its role in tumorigenesis and the relationship between survivin expression and apoptotic and/or proliferative activity in many types of human tumor including non-Hodgkin’s Lymphomas. Such studies have not been conducted in canine lymphomas. The aim of this study was to evaluate the expression of survivin in canine lymphomas of low (5/25) and high (20/25) grades in relation to apoptotic markers (apoptotic index and index of caspase-3). Survivin was found in all examined lymphomas. Most tumors (18/25) showed survivin expression in 10%-25% of positive cells. Only in single cases was lower (0-10% positive cells, 1/25) or higher (25%-50% and >50% positive cells, 5/25 and 1/25, respectively) survivin expression. No significant differences between mean values of either index of survivin or apoptotic index was found between low and high grade lymphomas. However, such a difference among lymphoma grades was shown regarding the caspase-3 index. No correlation between the survivin index and either the apoptotic index or caspase-3 index was found, irrespective of the method of quantification: in whole specimens or in areas of low and high survivin expression. Positive correlation was consistently noted only between both apoptotic markers. The results indicate that survivin is commonly expressed in canine lymphomas. It seems that survivin does not exhibit anti-apoptotic activity in canine lymphomas. Lack of correlation between survivin expression and apoptotic markers could indicate its potential role in cell cycle activation in lymphoma cells.
Źródło:: Polish Journal of Veterinary Sciences; 2017, 20, 2
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Komórki C tarczycy w warunkach fizjologicznych i stanach patologicznych. Część I. Różnicowanie, morfologia, lokalizacja i funkcje komórek C
C cells in normal and pathological conditions. Part I. Development, morphology, localization and functions of C cells
Autorzy:: Sokolowska, J.
Urbanska, K.
Powiązania:: https://bibliotekanauki.pl/articles/860054.pdf
Data publikacji:: 2018
Wydawca:: Krajowa Izba Lekarsko-Weterynaryjna
Tematy:: tarczyca
komorki endokrynowe tarczycy
komorki C
roznicowanie komorek
morfologia
ultrastruktura
lokalizacja
funkcje wydzielnicze
kalcytonina
peptydy regulacyjne
Źródło:: Życie Weterynaryjne; 2018, 93, 07
0137-6810
Pojawia się w:: Życie Weterynaryjne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Komórki C tarczycy w warunkach fizjologicznych i stanach patologicznych. Część II. Rozrost komórek C i rak rdzeniasty
C cells in normal and pathological conditions. Part II. C cells hyperplasia and medullary carcinoma
Autorzy:: Sokolowska, J.
Urbanska, K.
Powiązania:: https://bibliotekanauki.pl/articles/859439.pdf
Data publikacji:: 2018
Wydawca:: Krajowa Izba Lekarsko-Weterynaryjna
Tematy:: tarczyca
komorki endokrynowe tarczycy
komorki C
rozrost odczynowy komorek C
rozrost nowotworowy
rak rdzeniasty tarczycy
zespol mnogiej gruczolakowatosci wewnatrzwydzielniczej
badania histologiczne
badania mikroskopowe
diagnostyka immunohistochemiczna
Źródło:: Życie Weterynaryjne; 2018, 93, 08
0137-6810
Pojawia się w:: Życie Weterynaryjne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Proliferation activity in canine lymphomas
Autorzy:: Sokolowska, J.
Micun, J.
Malicka, E.
Lechowski, R.
Powiązania:: https://bibliotekanauki.pl/articles/31622.pdf
Data publikacji:: 2012
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Forty five lymphomas, 14 of T cell origin, 28 of B cell and 3 with null-cell phenotype, were included in this study. Tumors were classified according to the updated Kiel classification system adapted to canine lymphomas. The percentage of Ki67+ cells and mitotic index (MI) were estimated in each specimen. Most of lymphomas (39 of 45) had high proliferation activity. Among them in 27 cases 50-70% of lymphoma cells expressed Ki67, the highest Ki67 expression (>70% Ki67+ cells) was identified less frequently, in 12 cases. Moderate Ki67 expression (20-50% positive cells) was observed in 5 cases, only one tumor had low Ki67 expression (<20% positive cells). Lower percentage of Ki67+ cells was usually accompanied with lower MI. The mean MI values in discussed groups differed significantly. Mean MI value was also significantly higher in T cell than in B cell lymphomas (4.30 vs. 3.33). Moreover, high positive correlation between the expression of Ki67 and MI was found (r = 0.668; P ≤ 0.001). In T-cell tumors the correlation was very high (r = 0.83; P ≤ 0.001) and in B-cell lymphomas the correlation was high (r = 0.61; P ≤ 0.001). There were also differences between mean MI values in the lymphomas of different morphological subtypes, but in some of them high variations in the range of MI values were identified and wide overlaps of MI between individual cases from different subtypes were observed. Because of differences in the proliferation activity in single cases of the same subtype of lymphoma, the proliferation activity assessment may be helpful to chose appropriate scheme of treatment and should be commonly performed during routine histopathological diagnosis of canine lymphomas.
Źródło:: Polish Journal of Veterinary Sciences; 2012, 15, 4
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Rola glikoproteiny P w warunkach fizjologicznych i w stanach patologicznych. Część I. Budowa chemiczna i biologiczna rola glikoproteiny P
The role of P-glycoprotein under physiological and pathological conditions. Part I. Structure and biological role of P-glycoprotein
Autorzy:: Sokolowska, J.
Urbanska, K.
Klosinska, D.
Powiązania:: https://bibliotekanauki.pl/articles/858805.pdf
Data publikacji:: 2014
Wydawca:: Krajowa Izba Lekarsko-Weterynaryjna
Tematy:: transportery blonowe
glikoproteina P
budowa
mechanizm dzialania
funkcje biologiczne
aktywnosc biologiczna
gen MDR1
polimorfizm genetyczny
nadwrazliwosc na leki
Źródło:: Życie Weterynaryjne; 2014, 89, 11
0137-6810
Pojawia się w:: Życie Weterynaryjne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Rola glikoproteiny P w warunkach fizjologicznych i stanach patologicznych. Część II. Znaczenie glikoproteiny P w patogenezie niektórych chorób i rozwoju oporności wielolekowej
The role of P-glycoprotein under physiological and pathological conditions. Part II. Importance of P-glycoprotein in pathogenesis of certain diseases and development of multidrug resistance
Autorzy:: Sokolowska, J.
Urbanska, K.
Klosinska, D.
Powiązania:: https://bibliotekanauki.pl/articles/861549.pdf
Data publikacji:: 2014
Wydawca:: Krajowa Izba Lekarsko-Weterynaryjna
Tematy:: transportery blonowe
glikoproteina P
stan patologiczny
choroby zwierzat
patogeneza
komorki nowotworowe
opornosc wielolekowa
inhibitory glikoproteiny P
Źródło:: Życie Weterynaryjne; 2014, 89, 12
0137-6810
Pojawia się w:: Życie Weterynaryjne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Immunohistochemical study of expression of immunoglobulins in canine B-cell lymphomas
Autorzy:: Sokolowska, J.
Micun, J.
Zabielska, K.
Malicka, E.
Lechowski, R.
Powiązania:: https://bibliotekanauki.pl/articles/31685.pdf
Data publikacji:: 2010
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: immunohistochemistry
expression
immunoglobulin
dog
B cell
lymphoma
tumour
neoplastic cell
immunoglobulin light chain
cancer
Opis:: Nineteen canine lymphomas were included in this study. Tumors were classified according to the updated Kiel classification adapted for canine lymphomas by Fournel-Fleury et al. Immunoglobulin light chains (κ and λ) and IgM and IgG expression were determined by immunohistochemical method. In all examined cases neoplastic cells were positive for one of the immunoglobulin light chains. Expression of λ light chains and κ light chains was observed in 18/19 and 1/19 tumors, respectively. In the majority of neoplastic cells in each examined specimen this reaction had a membranous pattern (sκ/sλ). In all examined cases the presence of immunoglobulin light chains was also observed in the cytoplasm of some neoplastic cells (cκ/cλ). These cells were usally rare and never constituted a dominant population. The expression of immunoglobulin was found in 13/19 cases. Most lymphomas were sIgM positive (11/13 cases). In one case expression of IgG was found, and in another lymphoma two populations of neoplastic cells with different expression of examined immunoglobulins (cells with IgM+ and IgG+ phenotypes) were observed. The reaction also had a membranous pattern. The cells containing cytoplasmic immunoglobulins were rare, and in most cases were of the same type as the surface immunoglobulins. Our study has confirmed that canine lymphomas are a monoclonal proliferation of B-cells usually expressing immunoglobulin λ light chains and that the vast majority of tumors deriving from B-cells express IgM. Our study also indicates a possibility of occurence of biclonal lymphomas in canine species.
Źródło:: Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Wpływ gonadektomii na budowę histologiczną tarczycy u psów
Influence of gonadectomy on histological structure of thyroid gland in dogs
Autorzy:: Krzyzewska-Mlodawska, A.
Max, A.
Grabiec, A.
Sokolowska, J.
Powiązania:: https://bibliotekanauki.pl/articles/860959.pdf
Data publikacji:: 2014
Wydawca:: Krajowa Izba Lekarsko-Weterynaryjna
Tematy:: psy
samce
samice
gonadektomia
orchiektomia
owariohisterektomia
tarczyca
budowa histologiczna
Źródło:: Życie Weterynaryjne; 2014, 89, 05
0137-6810
Pojawia się w:: Życie Weterynaryjne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Classification of brown earths based on field and laboratory properties: problematic issues and proposition of their solution
Autorzy:: Woznica, K.
Jozefowska, A.
Sokolowska, J.
Mazurek, R.
Zaleski, T.
Powiązania:: https://bibliotekanauki.pl/articles/971311.pdf
Data publikacji:: 2019
Wydawca:: Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Tematy:: brown earths
polish soil classification
field guide
cambisols
Opis:: In this paper, the current problems associated with the classification of brown earths, are presented. According to the Polish Soil Classification (PSC) (1989, 2011), base saturation is the main parameter for identifying eutrophic and dystrophic brown soils. In practice, however, it is not possible to determine the base saturation value in the field. Therefore, the aim of this study was to estimate the base saturation using a regression equation and create a field guide for brown earths, based on the pH value, measured using a Hellige indicator, and the calcium carbonate content. Determination of the pH ranges enabled the classification of brown earth types in the field. These results suggest that pH can be used as a proxy for base saturation especially in the field. A change in the hierarchy of soil (sub)types is proposed for the new Polish Soil Classification.
Źródło:: Polish Journal of Soil Science; 2019, 52, 2; 225-234
0079-2985
Pojawia się w:: Polish Journal of Soil Science
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Immunohistochemical detection of P-glycoprotein in various subtypes of canine lymphomas
Autorzy:: Sokolowska, J.
Urbanska, K.
Gizinski, S.
Zabielska, K.
Lechowski, R.
Powiązania:: https://bibliotekanauki.pl/articles/2087980.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Combination chemiotherapy is the current standard of care for dogs with lymphoma. Multidrug resistance is one of the most important factors contributing to the efficacy of chemiotherapy. The major protein responsible for this phenomenon is P-glycoprotein. Little is known about P-glycoprotein expression in particular subtypes of lymphomas. The aim of the study was evaluation of P-glycoprotein expression in various subtypes of canine lymphomas. Positive reaction with P-glycoprotein was found in 12/25 cases of various morphological subtypes of lymphomas, however, in 3/11 lymphomas the percentage of positively weakly stained cells was <10% and those tumors were also considered negative. Tumors with 10-50% P-glycoprotein positive cells were found in single cases of centroblastic and centroblastic-centrocytic tumors. In 5 lymphomas P-glycoprotein expression exceeded 50% of tumor cells. Those cases were found among centroblastic, centroblastic-centrocytic, lymphoblastic and Burkitt-like subtypes. Positive reaction was observed mainly in the cell cytoplasm, however, in some cases prominent perinuclear dot-like staining pattern was found. In 2 cases focal staining pattern comprised dominant type of immunolabelling. Among all lymphomas containing P-glycoprotein positive cells intensity of imunolabelling was assessed as weak (6/25), moderate (2/25) and strong (3/25). Our results indicate that P-glycoprotein expression is present in nearly one third of newly diagnosed canine lymphomas of different morphological subtypes including those most commonly occurring, such as cenroblastic lymphomas. Hence, determination of P-glycoprotein expression at the time of diagnosis could provide valuable information for the design of treatment protocols. Moreover, our results have shown that P-glycoprotein expression in canine tumors could be located in Golgi-zone.
Źródło:: Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Survivin expression in canine lymphomas in relation with proliferative markers
Autorzy:: Sokolowska, J.
Urbanska, K.
Gizinski, S.
Wysocka, A.
Cywinska, A.
Lechowski, R.
Powiązania:: https://bibliotekanauki.pl/articles/2087990.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Survivin is a member of apoptosis inhibiting proteins family. Apart from its antiapoptotic activity it plays a critical role in regulating the cell cycle and mitosis. It is overexpressed in most human malignancies. While the prognostic significance of survivin expression is widely investigated in human non-Hodgkin's lymphomas, little is known about its expression in canine lymphomas. The aim of the study was to evaluate the expression of survivin in canine lymphomas in relation to proliferation markers (mitotic index and percentage of Ki67-positive cells). Survivin was found in all examined lymphomas belonging to 6 different morphological subtypes with nuclear immunoreactivity. In most of lymphomas (18/25) survivin expression ranged 10%-25% of positive cells. Only single cases had lower (0-10% positive cells, 1/25) or higher (25-50% and >50% positive cells, 5/25 and 1/25, respectively) index of survivin. Neither mitotic index nor proliferative index correlated with survivin expression when the values quantified randomly in whole specimens were compared. However, when survivin expression were quantified in selected tumor areas of low and high proliferation activity the high correlations between survivin expression and proliferation index were found. The results indicated that survivin is commonly expressed in canine lymphomas. Nuclear labelling together with the relation of its expression and proliferative activity in highly proliferative areas of neoplastic tissue suggest a potential role of survivin in cell cycle activation in canine lymphoma cells. However, further studies of the relation between expression of survivin and other proteins involved in cell cycle regulation are needed. Moreover, the results suggest that survivin may pose the therapeutic target in canine lymphomas.
Źródło:: Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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