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Wyświetlanie 1-5 z 5
Tytuł:
Pattern recognition approach to differentiation of disease severity in patients with amyotrophic lateral sclerosis
Autorzy:
Jóźwik, A.
Sokołowska, B.
Niebroj-Dobosz, I.
Janik, P.
Kwieciński, H.
Powiązania:
https://bibliotekanauki.pl/articles/333433.pdf
Data publikacji:
2008
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
rozpoznawanie obrazu
klasyfikacja K-NN
erytropoetyna
pattern recognition
k-NN classifier
amyotropic lateral sclerosis
erythropoietin
Opis:
A possibility of recognition of the clinical status of patients with amyotrophic lateral sclerosis (ALS) in relation to severity of the disease was investigated. Three groups: (i) healthy controls (n=15) and two subgroups of ALS patients (ii) mild (n=15) and (iii) severe (n=15) were considered as classes. Four features of the subjects: (i) their age (AGE) (ii) erythropoietin concentration in serum (SERUM), (iii) in cerebrospinal fluid (CSF), and (iv) duration time of the disease (Tdis) were used for classifier construction based on the k Nearest Neighbours (k-NN) rule, known from pattern recognition theory. The presented results demonstrate that the pattern recognition approach may be useful for the evaluation of the severity of the ALS disease.
Źródło:
Journal of Medical Informatics & Technologies; 2008, 12; 143-147
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of matrix metalloproteinases (MMPs) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis (ALS)
Autorzy:
Sokołowska, B.
Jóźwik, A.
Niebroj-Dobosz, I.
Janik, P.
Kwieciński, H.
Powiązania:
https://bibliotekanauki.pl/articles/333116.pdf
Data publikacji:
2009
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
klasyfikacja K-NN
stwardnienie zanikowe boczne
metaloproteinazy macierzy
płyn mózgowo-rdzeniowy
pattern recognition
k-NN classifier
amyotrophic lateral sclerosis
matrix metalloproteinase
cerebrospinal fluid
Opis:
Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of motor neuron degeneration in amyotrophic lateral sclerosis (ALS) and might be potential markers of diagnosis, prognosis and monitoring treatment effects. The aim of the present study was evaluation of the MMPs significance in cerebrospinal fluid (CSF MMPs) of patients with ALS in relation to severity of the disease. Metalloproteinases MT-MMP-1, MMP-2, MMP-9 and additionally age of subjects and disease duration were analyzed. The results demonstrate that the error of differentiation between healthy subjects and ALS patients (for MMP-2 feature) as well as between mild and severe ALS states (for CSF MMPs set) equalled to 0.033. In conclusion, the pattern recognition approach may be useful for differentation of ALS progressing on the basis of CSF MMPs features.
Źródło:
Journal of Medical Informatics & Technologies; 2009, 13; 147-150
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Estimation of significance of AlkB and AlkA proteins in DNA repair in Escherichia coli model
Autorzy:
Sokołowska, B.
Maciejewska, A. M.
Jóźwik, A.
Kuśmierek, J. T.
Powiązania:
https://bibliotekanauki.pl/articles/333316.pdf
Data publikacji:
2011
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
rozpoznawanie obrazów
klasyfikator najbliższych sąsiadów
analiza cech pracy odbiornika
naprawa DNA
adaptacyjna odpowiedź
powstawanie mutacji
bakterie e.coli
pattern recognition
fuzzy k-NN classifier
ROC analysis
DNA repair
adaptive response
mutagenesis
AlkB dioxygenase
AlkA glycosylase
E.coli
Opis:
The paper concerns estimation of significance of differences of mutagenesis level between the wild-type strain (wt) and its derivatives which differ in DNA repair ability, namely alkA and alkB strain, devoided AlkA glycosylase and AlkB dioxygenase activity, respectively. The strains were analyzed for their ability to repair 1,N6-ethenoadenine (εA) - chloroacetaldehyde adduct to DNA. The analysis was done using classical statistical and pattern recognition methods. The obtained results confirmed that AlkB dioxygenase plays the most important role in εA repair in E. coli in the experimental modeling.
Źródło:
Journal of Medical Informatics & Technologies; 2011, 17; 321-326
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The pair-wise linear classifier and the k-NN rule in application to ALS progression differentiation
Autorzy:
Sokołowska, B.
Jóźwik, A.
Niebroj-Dobosz, I.
Janik, P.
Powiązania:
https://bibliotekanauki.pl/articles/333011.pdf
Data publikacji:
2012
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
rozpoznawanie wzorców
wybór funkcji
klasyfikator liniowy
zasada k-NN
biomarkery
stwardnienie zanikowe boczne
pattern recognition
feature selection
linear classifier
k-NN rule
pair-wise classifier
biomarkers
amyotrophic lateral sclerosis
Opis:
The two kinds of classifier based on the k-NN rule, the standard and the parallel version, were used for recognition of severity of ALS disease. In case of the second classifier version, feature selection was done separately for each pair of classes. The error rate, estimated by the leave one out method, was used as a criterion as for determination the optimum values of k's as well as for feature selection. All features selected in this manner were used in the standard and in the parallel classifier based on k-NN rule. Furthermore, only for the verification purpose, the linear classifier was applied. For this kind of classifier the error rates were calculated by use the training set also as a testing one. The linear classifier was trained by the error correction algorithm with a modified stop condition. The data set concerned with the healthy subjects and patients with amyotrophic lateral sclerosis (ALS). The set of several biomarkers such as erythropoietin, matrix metalloproteinases and their tissue inhibitors measured in serum and cerebrospinal fluid (CSF) were treated as features. It was shown that CSF biomarkers were very sensitive for the ALS progress.
Źródło:
Journal of Medical Informatics & Technologies; 2012, 20; 79-83
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pattern recognition approach for analysis of metabolic response to intermittent hypoxia
Autorzy:
Sokołowska, B.
Jóźwik, A.
Powiązania:
https://bibliotekanauki.pl/articles/333610.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
rozpoznawanie wzorców
zasada k-NN
przerywane niedotlenienie
metaboliczna odpowiedź
pattern recognition
k-NN rule
pair-wise classifier
intermittent hypoxia
metabolic response
Opis:
Intermittent hypoxia (IH) elicits two forms of respiratory plasticity, which are initiated during and after exposure to IH, i.e. a long-term facilitation and a progressive augmentation of respiratory motor output. IH is often used as a model of sleep apnea and/or respiratory plasticity in humans and animals. Procedures of IH are also applied in sport medicine and rehabilitation of respiratory diseases. The aim of the present paper is an analysis of a metabolic response to acute intermittent hypoxia in a rat model. The animals were placed and monitored in a whole body plethysmographic chamber. The rats were exposed to five consecutive cycles consisting of 10-min hypoxic stimulus period separated by 10-min normoxic intervals, and additionally they were monitored up to 1 h after the final hypoxic exposure. The metabolism software analyzer recorded following variables (features): metabolic rate, carbon dioxide production, oxygen consumption and respiratory quotient. The obtained results demonstrated that acute IH causes metabolic effects during and after intermittent stimuli, which may be effectively recognized by an application of the k-NN classifiers.
Źródło:
Journal of Medical Informatics & Technologies; 2010, 15; 177-183
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-5 z 5

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