- Tytuł:
- DALDA analogues containing α-hydroxymethylamino acids.
- Autorzy:
-
Olma, Aleksandra
Chung, Nga
Schiller, Peter
Zabrocki, Janusz - Powiązania:
- https://bibliotekanauki.pl/articles/1044058.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
amphiphilic amino acids
α-hydroxymethylamino acids
DALDA analogues
opioid activity in vitro
opioid peptides - Opis:
- To evaluate the role of aromatic amino-acids residues, four analogues of the μ-selec-tive opioid peptide agonist DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) containing the amphiphilic, α,α-disubstituted amino acid (R)- or (S)-α-hydroxymethyltyrosine (HmTyr) in position 1 and (R)- or (S)-α-hydroxymethylphenylalanine (HmPhe) in position 3 of the peptide sequence were synthesized. Only the [(R)-HmPhe3)]DALDA analogue displayed full agonistic activity in both the guinea pig ileum and the mouse vas deferens assays and turned out to be a δ receptor-selective opioid agonist.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 4; 1121-1124
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł