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Wyszukujesz frazę "selective antibacterial peptides" wg kryterium: Wszystkie pola


Wyświetlanie 1-2 z 2
Tytuł:
Characterization of a possible uptake mechanism of selective antibacterial peptides
Autorzy:
Polanco, Carlos
Samaniego, José
Castañón-González, Jorge
Buhse, Thomas
Sordo, Marili
Powiązania:
https://bibliotekanauki.pl/articles/1039457.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Polarity index method
cell penetrating peptides
selective antibacterial peptides
Opis:
Selective antibacterial peptides containing less than 30 amino acid residues, cationic, with amphipathic properties, have been the subject of several studies due to their active participation and beneficial effects in strengthening the immune system of all living organisms. This manuscript reports the results of a comparison between the group of selective antibacterial peptides and another group called "cell penetrating peptides". An important number of the selective antibacterial peptides are cell penetrating peptides, suggesting that their toxicity is related to their uptake mechanism. The verification of this observation also includes the adaptation of a method previously published, called Polarity index, which reproduces and confirms the action of this new set of peptides. The efficiency of this method was verified based on four different databases, yielding a high score. The verification was based exclusively on the peptides already reported in the databases which have been experimentally verified.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 629-633
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection of selective antibacterial peptides by the Polarity Profile method
Autorzy:
Polanco, Carlos
Buhse, Thomas
Samaniego, José
Castañón-González, Jorge
Powiązania:
https://bibliotekanauki.pl/articles/1039571.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
selective cationic amphipathic antibacterial peptides
Polarity Profile method
Polarity Index method
Opis:
Antimicrobial peptides occupy a prominent place in the production of pharmaceuticals, because of their effective contribution to the protection of the immune system against almost all types of pathogens. These peptides are thoroughly studied by computational methods designed to shed light on their main functions. In this paper, we propose a computational approach, named the Polarity Profile method that represents an improvement to the former Polarity Index method. The Polarity Profile method is very effective in detecting the subgroup of antibacterial peptides called selective cationic amphipathic antibacterial peptides (SCAAP) that show high toxicity towards bacterial membranes and exhibit almost zero toxicity towards mammalian cells. Our study was restricted to the peptides listed in the antimicrobial peptides database (APD2) of December 19, 2012. Performance of the Polarity Profile method is demonstrated through a comparison to the former Polarity Index method by using the same sets of peptides. The efficiency of the Polarity Profile method exceeds 85% taking into account the false positive and/or false negative peptides.
Źródło:
Acta Biochimica Polonica; 2013, 60, 2; 183-189
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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