- Tytuł:
- Evaluation of anti-manic activity of pregabalin in a mouse model of methylphenidate-induced mania
- Autorzy:
-
MALIKOWSKA, Natalia
GRZYWA, Anna
ŚLADOWSKA, Joanna
SAŁAT, Kinga
LIBROWSKI, Tadeusz
GDULA-ARGASIŃSKA, Joanna - Powiązania:
- https://bibliotekanauki.pl/articles/1033806.pdf
- Data publikacji:
- 2017
- Wydawca:
- Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
- Tematy:
-
anxiety
bipolar disorder
depression
mania
metylphenidate
pregabalin - Opis:
- Mania is a psychiatric disorder which may occur alternately with depression as a bipolar disorder, or much less often as an individual disease. It might be accompanied by other disorders, i.e. schizophrenia, dementia or withdrawal syndrome. Only a few effective drugs are used for the treatment of mania. Patients suffering from bipolar disorder are treated with mood-stabilizing drugs, administered during the course of the disease, and drugs that are implemented when mania or depression episodes occur. Some studies report effectiveness of anticonvulsant drugs in the cessation of mania, thus in our study we assessed the effectiveness of pregabalin in a mouse model of mania induced by administration of metylphenidate (5 mg/kg; s.c). Pregabalin was tested in the forced swim test (75 mg/kg, 100 mg/kg; i.p.) and the elevated plus maze test (75 mg/kg; i.p.) to assess its antidepressant-like and anxiolytic-like properties, respectively. In the elevated plus maze in MPH-treated mice pregabalin significantly reduced time spent in open arms (p<0.001 vs. MPH-treated control). In the forced swim test MPH compared to vehicle significantly (p<0.001) reduced duration of immobility. In MPH-treated mice pregabalin partially reversed this effect of MPH. This effect was significant only for the dose of 75 mg/ kg (p<0.05). In the rotarod test neither MPH, nor its combination with pregabalin (75 mg/kg; 100 mg/kg) influenced motor coordination of mice at any speed tested. To conclude our study revealed that pregabalin might reverse manic-like action of MPH related to hyperlocomotion, which may indicate for its possible effectiveness in mania episodes.
- Źródło:
-
Medicina Internacia Revuo; 2017, 28, 108; 196-201
0465-5435 - Pojawia się w:
- Medicina Internacia Revuo
- Dostawca treści:
- Biblioteka Nauki
Artykuł