Autor: Urbańska, Krystyna - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas.
Autorzy:: Urbanska, Krystyna
Romanowska-Dixon, Bożena
Matuszak, Zenon
Oszajca, Janusz
Nowak-Sliwinska, Patrycja
Stochel, Grażyna
Powiązania:: https://bibliotekanauki.pl/articles/1043767.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: melanoma
photodynamic therapy
indocyanine green
Opis:: Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (λex = 830 nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.
Źródło:: Acta Biochimica Polonica; 2002, 49, 2; 387-391
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Metastasis inhibition after proton beam, β- and γ-irradiation of melanoma growing in the hamster eye
Autorzy:: Romanowska-Dixon, Bożena
Elas, Martyna
Swakoń, Jan
Sowa, Urszula
Ptaszkiewicz, Marta
Szczygieł, Małgorzata
Krzykawska, Martyna
Olko, Paweł
Urbańska, Krystyna
Powiązania:: https://bibliotekanauki.pl/articles/1039523.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: metastases
melanoma
ocular
proton beam
iodine-125
ruthenium-106
Opis:: Standard ocular tumor treatment includes brachytherapy, as well as proton therapy, particularly for large melanoma tumors. However, the effects of different radiation types on the metastatic spread is not clear. We aimed at comparing ruthenium (106Ru, emitting β electrons) and iodine (125I, γ-radiation) brachytherapy and proton beam therapy of melanoma implanted into the hamster eye on development of spontaneous lung metastases. Tumors of Bomirski Hamster Melanoma (BHM) implanted into the anterior chamber of the hamster eye grew aggressively and completely filled the anterior chamber within 8-10 days. Metastases, mainly in the lung, were found in 100% of untreated animals 30 days after enucleation. Tumors were irradiated at a dose of 3-10 Gy with a 106Ru plaque and at a dose of 6-14 Gy using a 125I plaque. The protons were accelerated using the AIC-144 isochronous cyclotron operating at 60 MeV. BHM tumors located in the anterior chamber of the eye were irradiated with 10 Gy, for the depth of 3.88 mm. All radiation types caused inhibition of tumor growth by about 10 days. An increase in the number of metastases was observed for 3 Gy of β-irradiation, whereas at 10 Gy an inhibition of metastasis was found. γ-radiation reduced the metastatic mass at all applied doses, and proton beam therapy at 10 Gy also inhibited the metastastic spread. These results are discussed in the context of recent clinical and molecular data on radiation effects on metastasis.
Źródło:: Acta Biochimica Polonica; 2013, 60, 3; 307-311
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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