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Wyświetlanie 1-2 z 2
Tytuł:
THE EEG EXAMINATION, TOGETHER WITH P300 POTENTIAL AS A METHOD FOR CAUSATIVE DIFFERENTIATION IN PATIENTS WITH A GENETIC AND ENVIRONMENTAL CONDITIONING TO ALCOHOL ADDICTION
Autorzy:
Chwedorowicz, Roman
Raszewski, Grzegorz
Studziński, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/2137788.pdf
Data publikacji:
2017-12-23
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
Alcoholism
Evoked potentials P300
Endophenotype
Opis:
The electrophysiological characteristics of alcoholics, such as the P300 amplitude of the Event-Related Potential (ERP), are related to high risk in their offspring, and are considered to be biological endophenotypes of a predisposition to develop alcohol use disorders. Contemporary knowledge justifies early diagnoses of the alcohol risk degree among adolescents, or even children, including their families, involving an examination of the P300 potential as an endophenotype, prior to achievement of an age of alcohol initiation. The results of such research approaches may be of importance not only cognitively, but also of prophylactically, in the early recognition of increased susceptibility to alcohol. The simplicity and non-invasiveness, and the exceptionally low costs of the methods described, should obtain for the present as well as in the future, a wider examination, one potentially even mass scope of in character and usefulness. The knowledge of such an endophenotype and genetically-related susceptibility, in the individual, family, and social dimension and transmission, and in the rearing of children and adolescents, could protect – not just individuals – but many from entering into the route of addiction, which is most frequently the effect of acting unaware and with negative life consequences, both generational and transgenerational for generations to come.
Źródło:
Acta Neuropsychologica; 2017, 15(4); 457-465
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage
Autorzy:
Chwedorowicz, Roman
Raszewski, Grzegorz
Kapka-Skrzypczak, Lucyna
Sawicki, Krzysztof
Studziński, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/991182.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Tematy:
alcohol dependence
event-related potentials
resting theta eeg power
sgip1 snps
Opis:
Objective. The electrophysiological characteristics may serve as valuable biomarkers for the genetic vulnerability underlying alcoholism. The purpose of this study was to evaluate the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and the theta ERP quantitative traits. Method. The theta band (4–7 Hz) visual ERP occurring in the P300 response in the resting EEG were examined to explore the electrophysiological effects of alcohol on the brain in five regions: frontal, central, parietal, temporal and occipital in patients with alcohol addiction. In addition, we tested the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and ERP quantitative traits. Results. We found that the amplitude of the auditory P300 response differed considerably among groups of alcoholics in the frontal, central and temporal areas of the brain and it was lower in the studied brain regions in alcoholics in comparison to non-alcoholics. However, among subjects in the young adult group (GR-1) there was no statistical difference in amplitude of P300 response with control subjects in all studied brain regions in comparison with non-alcoholics. Moreover, we revealed that SNP rs10889635 had a significant effect on P300 amplitude in the central and temporal regions. The reduced P300 amplitude was in AA carriers in comparison to both carriers of GG and GA alleles. Conclusion. The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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