- Tytuł:
- Microwave assisted synthesis, spectral studies and antimicrobial activities of some 2′,4′-difluorophenyl chalcones
- Autorzy:
-
Vijayakumar, S.
Arulkumaran, R.
Sundararajan, R.
Sakthinathan, S. P.
Suresh, R.
Kamalakkannan, D.
Ranganathan, K.
Sathiyamoorthy, K.
Mala, V.
Vanangamudi, G.
Thirunarayanan, G. - Powiązania:
- https://bibliotekanauki.pl/articles/412217.pdf
- Data publikacji:
- 2013
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
Microwave irradiation
Aldol condensation
Hydroxyapatite
Spectral correlations
Hammett σ constants
antimicrobial activities - Opis:
- Some 2′,4′-difluorophenyl chalcones have been synthesized under microwave irradiation using aldol condensation between 2,4-difluoroacetophenone and substituted benzaldehydes using catalytic amount of hydroxyapatite. The yields of the chalcones are more than 85 %. The purities of these synthesized chalcones were examined by their physical constants and spectroscopic data. The UV absorption maxima (λmax, nm), infrared stretches (ν, cm-1) of CO, fingerprint region of CHip/op, CH=CHop, C=Cop modes, NMR chemical shifts (δ, ppm) of vinyl proton, carbon and carbonyl carbons have been assigned and correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the statistical analysis the effect of substituent on the above spectral frequencies can be discussed. The antimicrobial activities of these synthesized chalcones have been screened using Bauer-Kirby method.
- Źródło:
-
International Letters of Chemistry, Physics and Astronomy; 2013, 9, 1; 68-86
2299-3843 - Pojawia się w:
- International Letters of Chemistry, Physics and Astronomy
- Dostawca treści:
- Biblioteka Nauki
Artykuł