- Tytuł:
- A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning
- Autorzy:
-
Lovrić, Jasna
Berend, Suzana
Lucić Vrdoljak, Ana
Radić, Božica
Katalinić, Maja
Kovarik, Zrinka
Želježić, Davor
Kopjar, Nevenka
Rast, Slavko
Mesić, Milan - Powiązania:
- https://bibliotekanauki.pl/articles/1039913.pdf
- Data publikacji:
- 2011
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
antidotal potential
atropine
genotoxicity
pyridine-4-aldoxime
organophosphates - Opis:
- A conjugate of pyridine-4-aldoxime and atropine (ATR-4-OX) was synthesized and its antidotal efficiency was tested in vitro on tabun- or paraoxon-inhibited acetylcholinesterase (AChE) of human erythrocytes as well as in vivo using soman-, tabun- or paraoxon-poisoned mice. Its genotoxic profile was assessed on human lymphocytes in vitro and was found acceptable for further research. ATR-4-OX showed very weak antidotal activity, inadequate for soman or tabun poisoning. Conversely, it was effective against paraoxon poisoning both in vitro and in vivo. All animals treated with 5 % or 25 % LD50 doses of the new oxime survived after administration of 10.0 or 16.0 LD50 doses of paraoxon, respectively. Based on the persistence of toxicity symptoms in mice, the atropine moiety had questionable effects in attenuating such symptoms. It appears that ATR-4-OX has a therapeutic effect related to the reactivation of phosphylated AChE, but not to receptor antagonization.
- Źródło:
-
Acta Biochimica Polonica; 2011, 58, 2; 193-198
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł