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    Wyświetlanie 1-4 z 4
    Tytuł:
    Rola wolnych rodników w regulacji procesów fizjologicznych
    Role of free radicals in physiological processes
    Autorzy:
    Gdula- Argasińska, Joanna
    Tyszka- Czochara, Małgorzata
    Paśko, Paweł
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1033782.pdf
    Data publikacji:
    2012
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    hormeza
    reaktywne formy azotu RFN
    reaktywne formy tlenu RFT
    regulacja procesów fizjologicznych
    równowaga redox
    wolne rodniki
    Opis:
    Free radicals containing one or more unpaired electrons have considerable reactivity. Those radicals derived from oxygen represent the most important class of such species. Free radicals generated in organism are reactive oxygen species (ROS) and reactive nitrogen species (RNS) well recognised for playing a dual role as both deleterious and beneficial species. The cumulative production of ROS/RNS is termed oxidative stress and were discovered in pathomechanism of many of diseases. It was observed that in medium concentration ROS and RNS are play a role in inflammation, apoptosis and as secondary messengers in intracellular signalling cascades.
    Źródło:
    Medicina Internacia Revuo; 2012, 25, 99; 41-46
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of brassica sprouts on short chain fatty acids concentration in stools of rats with thyroid dysfunction
    Autorzy:
    Dobrowolska-Iwanek, Justyna
    Zagrodzki, Paweł
    Prochownik, Ewelina
    Jarkiewicz, Aneta
    Paśko, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/895296.pdf
    Data publikacji:
    2019-12-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    thyroid dysfunction
    short chain fatty acids
    broccoli sprouts
    stool samples
    Opis:
    The aim of the study was to investigate the influence of kohlrabi and broccoli sprouts added to diet on the concentrations of short-chain fatty acids in faeces samples of rats with thyroid dysfunction. Two models of hypothyroidism were used. First one was based on the diet with iodine deficiency and the second by sulfadimethoxine addition to the animal drinking water. In most cases the concentrations of acetic acid, propanoic acid and butanoic acid in stool samples obtained from rats with thyroid dysfunction were insignificantly lower than found in control group. Moreover, almost in all cases the diet enriched with brassica sprouts insignificantly increased the concentration of fatty acids in investigated material. Significant positive correlation between concentrations of butanoic and acetic acids was found in different groups of rats. In conclusion, the addition of brassica or kohlrabi sprouts in rat’s diet may slightly alleviate the decline of concentrations of some fatty acids in stool of animals with thyroid dysfunction. Long term effects of this phenomenon should be evaluated in future studies.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1005-1014
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anti-inflammatory activities of garlic sprouts, a source of α-linolenic acid and 5-hydroxy-l-tryptophan, in RAW 264.7 cells
    Autorzy:
    Gdula-Argasińska, Joanna
    Paśko, Paweł
    Sułkowska-Ziaja, Katarzyna
    Kała, Katarzyna
    Muszyńska, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1038621.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Allium sativum sprouts
    indolic and phenolic compounds
    α-linolenic acid
    anti-inflammatory activity
    RAW 264.7 cells
    Opis:
    The purpose of this study was to analyze the indolic, phenolic, and fatty acid content and antioxidant activity of garlic sprouts growing in the dark and in the daylight. The pro- or anti-inflammatory properties of the garlic sprout extract were investigated by evaluating the cyclooxygenase-2 (COX-2), prostaglandin E synthase (cPGES), glutathione S transferase (GSTM1), nuclear factor NF-κB, peroxisome proliferator-activated receptors (PPARs), and aryl hydrocarbon receptor (AhR) protein levels in the RAW 264.7 cells activated with lipopolysaccharide (LPS). The highest amount of total indolic (73.56 mg/100 g f.w.) and phenolic compounds (36.23 mg/100 g f.w.) was detected in garlic sprouts grown in the daylight. Studies on antioxidant activity (the FRAP and DPPH method) of garlic sprouts showed that this activity is significantly higher for sprouts grown in full access to light when compared to those grown in the dark. In garlic sprout extracts, α-linolenic acid (ALA) was found to be in greater amount. COX-2 and cPGES level was lower when compared to LPS alone activated cells. After garlic extract treatment, higher level of GSTM1, PPARΥ, cytosolic p50 and p65 protein, as well as a lower NF-ĸB p50/p65 activity was noted in the RAW 264.7 cells which suggested PPARs and AhR transrepression mechanism of NF-ĸB signalling. The obtained results indicate Allium sativum sprouts are a rich source of n-3 fatty acids, indolic and phenolic compounds characterized by anti-inflammatory and antioxidative activity, which may support their high therapeutic and dietary potential.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 3; 551-559
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Identification of lipid derivatives in Hep G2 cells
    Autorzy:
    Gdula-Argasińska, Joanna
    Garbacik, Aneta
    Tyszka-Czochara, Małgorzata
    Woźniakiewicz, Michał
    Paśko, Paweł
    Czepiel, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1039495.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    human hepatocellular carcinoma cells HepG2
    eicosapentaenoic acid
    benzo(a)pyrene
    isoprostanes
    prostaglandins
    UHPLC/MS-TOF method validation
    Opis:
    Metabolism of polyunsaturated fatty acids results in biosynthesis of mediators with different physiological effects. These metabolites include prostaglandins, prostacyclins, isoprostanes and others that are important signalling molecules and regulate a variety of physiological and pathophysiological processes including inflammation. Prostaglandins and isoprostanes are produced by either non-enzymatic lipid peroxidation or by enzyme-induced peroxidation (cyclooxygenases and lipoxygenases). They are used as biomarkers of oxidative stress. The aim of our study was to assess the effect of eicosapentaenoic acid (EPA) supplementation with added benzo(a)pyrene (BaP) on HepG2 cells by using a UHPLC/MS-TOF method. This rapid and simple method was developed for the identification, separation and quantification of 8-iPGF3α, PGF3α, 8-isoPGF2α and 5-iPF2α in cultured cells. The UHPLC/MS-TOF method was validated. The calculated limit of detection was in the range of 0.16-0.50 ng/mL, precision (% RSD): 1.2-2.1% and recoveries better than 88%. This method empowered qualitative and quantitative analysis of the selected individual prostaglandins derived from arachidonic acid and eicosapentaenoic acid from cell extracts.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 4; 811-815
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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