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    Wyświetlanie 1-8 z 8
    Tytuł:
    Rola wolnych rodników w regulacji procesów fizjologicznych
    Role of free radicals in physiological processes
    Autorzy:
    Gdula- Argasińska, Joanna
    Tyszka- Czochara, Małgorzata
    Paśko, Paweł
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1033782.pdf
    Data publikacji:
    2012
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    hormeza
    reaktywne formy azotu RFN
    reaktywne formy tlenu RFT
    regulacja procesów fizjologicznych
    równowaga redox
    wolne rodniki
    Opis:
    Free radicals containing one or more unpaired electrons have considerable reactivity. Those radicals derived from oxygen represent the most important class of such species. Free radicals generated in organism are reactive oxygen species (ROS) and reactive nitrogen species (RNS) well recognised for playing a dual role as both deleterious and beneficial species. The cumulative production of ROS/RNS is termed oxidative stress and were discovered in pathomechanism of many of diseases. It was observed that in medium concentration ROS and RNS are play a role in inflammation, apoptosis and as secondary messengers in intracellular signalling cascades.
    Źródło:
    Medicina Internacia Revuo; 2012, 25, 99; 41-46
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    EVALUATION OF NUTRITIONAL AND MEDICINAL PROPERTIES OF BACOPA MONNIERI BIOMASS AND PREPARATIONS
    Autorzy:
    Muszyńska, Bożena
    krakowska, Agata
    Lazur, Jan
    Szewczyk, Agnieszka
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/895242.pdf
    Data publikacji:
    2018-12-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    dietary supplements
    phenolic compounds
    Bacopa monnieri
    artificial digestive juices
    bioelements
    Opis:
    Bacopa monnieri (Scrophulariaceae) is a well-known plant and has been used by humans for several thousand years. In traditional Hindu medicine, it is one of the most important medicinal plants. The aim of the work was to determine the content of Fe, Mg, and Zn and selected organic compounds before and after extraction into the artificial digestive juices obtained from preparations containing B. monnieri. Commercial preparations in the form of tablets and capsules and B. monnieri shoot cultures were used in the experiment. The metal content in the considered mineralized samples was analyzed by atomic absorption spectrometry and organic compounds by RP-HPLC method. The maximum measured content of the metals released into the digestive juices was as follows: Fe – 32.85; Mg – 367.51; and Zn – 16.41 mg/100 g of the preparation. The existing research shows that metals are best released into the artificial digestive juices from the B. monnieri shoot cultures, and least efficiently from the commercial preparations available in the form of tablets. The phenolic compounds analyzed in the methanol extracts and the extracts of the artificial digestive juices were as follows: protocatechuic acid, p-hydroxybenzoic acid, neochlorogenic acid, chlorogenic acid, isochlorogenic acid, caffeic acid, ferulic acid, cynaroside, trifolin, and luteolin. Bacoside A was only determined in the extracts from the B. monnieri shoot cultures. The experimental results revealed that B. monnieri distributed in the form of tablets did not break down in the artificial digestive juices during the considered time intervals.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1353-1361
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    QUANTITATIVE AND QUALITATIVE ANALYSIS OF FIXED-DOSE-COMBINATION PRODUCTS (FDC, POLYPILL) APPLIED IN POLYTHERAPY OF HYPERTENSIVE DISEASE. REVIEW
    Autorzy:
    Stolarczyk, Mariusz
    Apola, Anna
    Maślanka, Anna
    Kwiecień, Anna
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/895565.pdf
    Data publikacji:
    2018-10-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    analysis
    fixed-dose-combination
    Opis:
    Problems in polytherapy of hypertension combined with hyperlipidemia and the need of application of several pharmaceutical preparations have been widely explored by patients, physicians, and the pharmaceutical industry through testing and introduction of a fixed-dose-combination products (FDC). The paper presents different analytical methods of qualitative and quantitative analysis or stability testing of FDC preparations and laboratory prepared mixtures of composition consistent with the FDC products collected on the basis of publications from the last decade. It can significantly facilitate the study of the methods and conditions for the determination of active substances in polypills which contain at least three APIs, especially in cases involving this type of preparations used or tested for their application in polytherapy of hypertension.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1083-1094
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wybrane nieoperacyjne sposoby leczenia szyjnego odcinka kręgosłupa
    Some Non-Operative Ways of Cervical Spine Treatment
    Autorzy:
    Piechowicz, Jacek
    Tęsiorowski, Maciej
    Jasiewicz, Barbara
    Sobol, Jacek
    Piechowicz, Mateusz
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1034040.pdf
    Data publikacji:
    2013
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    cervical spine
    dyscopathy
    physiotherapy
    Opis:
    Though cervical spine disorders occur less frequently than lumbar spine problems, their course and final results may have severe implications for patients. Despite significant development in operative treatment of cervical spine; patients, if possible, choose conservative methods basing mainly on pharmacotherapy and rehabilitation (physiotherapy). A case report of non-operative treatment with use of selected techniques of manual therapy and physiotherapy is described. Achieved improvement allowed postponing the surgery, but we cannot exclude the necessity of operation in the future.
    Źródło:
    Medicina Internacia Revuo; 2013, 25, 100; 119-123
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
    Autorzy:
    Grzywacz, Agata
    Gdula-Argasińska, Joanna
    Muszyńska, Bożena
    Tyszka-Czochara, Małgorzata
    Librowski, Tadeusz
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1038990.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    metal responsive-transcription factor 1
    cell signaling
    inflammation
    NF-κB
    Opis:
    Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 491-498
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The importance of screening in the evaluation Of faulty posture in children
    Autorzy:
    Kuciel-Lewandowska, Jadwiga
    Paprocka-Borowicz, Małgorzata
    Kierzek, Andrzej
    Pozowski, Andrzej
    Boerner, Ewa
    Ratajczak, Barbara
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1033835.pdf
    Data publikacji:
    2012
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    body posture
    program
    prophylaxis
    Opis:
    The aim of the following work is to evaluate faulty posture rate among kindergarten children. The following article describes the objective and the character of the promotional and prophylactic program conducted by the Wrocław City Council (Urząd Miasta Wrocławia) concerning the “Keep straight” (“Trzymaj się prosto”) campaign. The program includes youth between age of seven and seventeen in whom slight symptoms of faulty posture, concerning lower limbs and the spine, were revealed during examination. The only prophylactic activity assumed by the “Keep it straight” campaign are corrective exercises in gymnasium and swimming pool. The screening of the children and youth also allows introductional diagnostics and recognition of permanent faults and direction of the patients to specialist treatment in orthopedic and rehabilitation clinics. The screening was conducted on the verge of October and November 2007. A physical posture examination method was used to evaluate the faults that appeared. The children from five of Wrocław`s kindergartens were examined. The following work presents the symptomatology of the most frequent faults and highlights the necessity of conducting prophylactic activity at a very young age. The faulty posture is a serious diagnostic and therapeutic problem among young children and can be a source of severe health problems in their future. 373 children were examined. Faulty posture was revealed among 295 what represents 79,08% of the patients; 78 were described as healthy (20,92%). There were 160 boys (80,8%) and 135 girls (77,14%) in the group with faulty posture. There were 38 (19,2%) boys without faulty posture and 40 (22,86%) girls in the same group.
    Źródło:
    Medicina Internacia Revuo; 2012, 25, 98; 21-26
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Determination of in vitro metabolism of new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy)propyl]piperidine
    Autorzy:
    Kryczyk-Poprawa, Agata
    Szafarz, Małgorzata
    Palak, Aneta Palak
    Łażewska, Dorota
    Kuś, Kamil
    Opoka, Włodzimierz
    Szymura-Oleksiak, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/895240.pdf
    Data publikacji:
    2019-10-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    1-[3-(4-tert-butylphenoxy)propyl]piperidin
    well-stirred model
    parallel tube model
    non-imidazole histamine H3 receptor antagonist
    Opis:
    Early understanding of the pharmacokinetics of drug candidates is essential during the evaluation of drug development process. DL76 1-[3-(4-tert-butylphenoxy)propyl]piperidine is a novel promising non-imidazole H3 receptor antagonist. Presented study was undertaken to compare with each other the predicted hepatic clearance values of DL76 calculated, using two most common mathematical models “well-stirred” and “parallel tube”, based on the data obtained in in vitro experiments. The metabolic intrinsic clearance of DL76 equaled to 0.4848 mL/min/mg protein was scaled up and the values of hepatic clearance estimated from "well-stirred" and "parallel tube" models were 55.47 mL/min/kg and 58.80 mL/min/kg, respectively. They were further compared with pharmacokinetic parameters calculated based on the concentration-time profile obtained following intravenous administration of DL76 to rats at the dose of 6 mg/kg. The estimated systemic serum clearance value of 144.5 mL/h/kg and blood clearance value of 81.17 mL/min/kg indicate the potential extrahepatic metabolism of the investigated compound. This study demonstrates the utility of rat liver microsomes for the prediction of DL76 hepatic clearance.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 877-884
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    RELEASE OF BIOACTIVE SUBSTANCES FROM FORMULATIONS CONTAINING ARTHROSPIRA PLATENSIS (SPIRULINA PLATENSIS)
    Autorzy:
    Muszyńska, Bożena
    Lazur, Jan
    Jękot, Barbara
    Krakowska, Agata
    Szewczyk, Agnieszka
    Sułkowska-Ziaja, Katarzyna
    Zimmer, Łukasz
    Poleszak, Ewa
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/895358.pdf
    Data publikacji:
    2018-10-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    zinc
    phenolic compounds
    artificial digestive juices
    Arthrospira platensis
    indole compounds
    Opis:
    Arthrospira platensis (Spirulina platensis) is a well-known microalga and has been utilized as a medicinal agent and foodstuff by humans since at least 16th century. The aim of this study was to determine zinc content as well as determine phenolic and indole compounds from commercial preparations containing Arthrospira platensis (lyophilizate, tablets, and capsules) before and after extraction with methanol and incubation with artificial digestive juices. The secondary aim of this study was to evaluate the quality of these preparations. The samples were incubated in artificial stomach juice and in intestinal juice. The samples were mineralized and their zinc(II) ions content was estimated using flame absorption atomic spectroscopy (F-AAS). The maximum zinc(II) ions content released into the digestive juices was found to be up to 1.6 mg 100 g-1 of the preparation. Phenolic compounds identified in the examined extracts are as follows: gallic acid; protocatechuic acid; 3,4-dihydroxyphenylacetic acid; p-hydroxybenzoic acid; syringe acid; cinnamic acid; and quercetin. Furthermore, indole compounds identified were 5-hydroxy-L-tryptophan, 5-methyl-L-tryptophan, L-tryptophan, tryptamine, and 5-methyltryptamine. Consequently, it was also found that the distributed Arthrospira platensis in the form of tablets does not disintegrate in the artificial digestive juices. Among the examined preparations, only hard capsules met the requirements of the European Pharmacopeia 8th ed.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1187-1199
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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