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Wyszukujesz frazę "Nowińska, Anna" wg kryterium: Wszystkie pola


Wyświetlanie 1-2 z 2
Tytuł:
Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats
Autorzy:
Folwarczna, Joanna
Nowińska, Barbara
Śliwiński, Leszek
Pytlik, Maria
Cegieła, Urszula
Betka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1039879.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bone histomorphometry
bone mechanical properties
bone mineralization
fenoterol
prednisolone
Opis:
Glucocorticoids and β2-adrenergic receptor agonists are the most commonly used drugs in the treatment of asthma. Both therapies are potentially dangerous to the skeletal system. The aim of the present study was to investigate the effects of fenoterol, a β2-receptor agonist, on the development of bone changes induced by glucocorticoid (prednisolone) administration in mature male rats. The experiments were carried out on 24-week-old male Wistar rats. The effects of prednisolone 21-hemisuccinate sodium salt (7 mg/kg s.c. daily) or/and fenoterol hydrobromide (1.4 mg/kg i.p. daily), administered for 4 weeks, on the skeletal system were studied. Bone turnover markers, geometric parameters, mass, mass of bone mineral in the tibia, femur and L-4 vertebra, bone histomorphometric parameters and mechanical properties of tibial metaphysis, femoral diaphysis and femoral neck were determined. Both prednisolone and fenoterol had damaging effects on the skeletal system of mature male rats. However, concurrent administration of fenoterol and prednisolone did not result in the intensification of the deleterious skeletal effect of either drug administered separately.
Źródło:
Acta Biochimica Polonica; 2011, 58, 3; 313-319
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of diosgenin, a steroidal sapogenin, on the rat skeletal system
Autorzy:
Folwarczna, Joanna
Zych, Maria
Nowińska, Barbara
Pytlik, Maria
Bialik, Magdalena
Jagusiak, Anna
Lipecka-Karcz, Maria
Matysiak, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1038814.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
diosgenin
skeletal system
osteoporosis
estrogen deficiency
rats
Opis:
Diosgenin is a steroidal sapogenin present in fenugreek and Dioscorea spp. as glycosides (saponins). Diosgenin has already been reported to inhibit osteoclastogenesis and to stimulate osteogenic activity of osteoblastic cells in vitro, and to exert some antiosteoporotic effects in rats in vivo. The aim of the present study was to investigate the effects of diosgenin administration on the skeletal system of rats with normal estrogen level and with estrogen deficiency induced by bilateral ovariectomy. The experiments were carried out on 3-month-old non-ovariectomized and ovariectomized Wistar rats, divided into control rats and rats receiving diosgenin (50 mg/kg p.o. daily) for 4 weeks. Serum bone turnover markers, bone mass and mineralization, histomorphometric parameters and mechanical properties were studied. Diosgenin improved some investigated parameters in both non-ovariectomized and ovariectomized rats, in which estrogen deficiency induced osteoporotic changes. Diosgenin increased compact bone formation and probably inhibited cancellous bone resorption, which led to improvement of mechanical properties of compact and cancellous bone. In conclusion, this in vivo study demonstrated that diosgenin may be one of sparse compounds increasing bone formation.
Źródło:
Acta Biochimica Polonica; 2016, 63, 2; 287-295
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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