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    Wyświetlanie 1-6 z 6
    Tytuł:
    Immunological determinants in a murine model of toluene diisocyanate-induced asthma
    Autorzy:
    Świerczyńska-Machura, Dominika
    Walusiak-Skorupa, Jolanta
    Nowakowska-Świrta, Ewa
    Piasecka-Zelga, Joanna
    Świercz, Radosław
    Pałczyński, Cezary
    Powiązania:
    https://bibliotekanauki.pl/articles/2180077.pdf
    Data publikacji:
    2012-09-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    toluene diisocyanate
    occupational asthma
    murine model
    allergic infl ammation
    cytokines
    Opis:
    Objectives: Diisocyanates (DIC) are highly reactive, low-molecular-weight chemicals which are the leading cause of occupational asthma (OA). The aim of the study was to analyze certain aspects of the pathogenesis of allergic infl ammation in the airways induced by toluene diisocyanate (TDI) in an experimental model in mice. Materials and Methods: The experiment was carried out on 50 female BALB/cJ/Han/IMP mice, which were exposed by inhalation (intranasal and in the inhalation chamber) to toluene diisocyanate (2,4-TDI). After the experiment, the bronchoalveolar lavage fluid (BALF) was collected from the animals, and the composition of the induced infl ammatory cells, and the concentrations of certain cytokines (IL-4, IL-5, TNF-α) were evaluated. Results: The total number of cells in BALF of the examined group of mice was signifi cantly higher compared to the control mice. There was also a signifi cant increase in neutrophils and eosinophils in the study group compared to the controls. The number of lymphocytes and macrophages did not differ signifi cantly between the two groups. A statistically signifi cant increase in the level of TNF-α was shown to occur in the group exposed to toluene diisocyanate in comparison to the control group. The concentration of IL-4 increased in the study group, compared to the control one, but the differences did not reach the level of signifi cance, p > 0.05. Such difference was not observed for IL-5. Conclusions: We developed a murine model of TDI-induced asthma which caused the infl ux of infl ammatory cells like eosinophils and neutrophils in the bronchoalveolar lavage fl uid (BALF) in the TDI-treated mice. The increase of the concentration of some proinfl ammatory cytokines (TNF-α, IL-4) in BALF from the exposed mice was also observed.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2012, 25, 4; 492-498
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Occupational asthma caused by samba (Triplochiton scleroxylon) wood dust in a professional maker of wooden models of airplanes: A case study
    Autorzy:
    Krawczyk-Szulc, Patrycja
    Wiszniewska, Marta
    Pałczyński, Cezary
    Nowakowska-Świrta, Ewa
    Kozak, Anna
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2178859.pdf
    Data publikacji:
    2014-06-21
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    occupational asthma
    wood dusts
    samba
    triplochiton scleroxylon
    specific inhalation challenge test
    Opis:
    Objectives: Wood dust is a known occupational allergen that may induce, in exposed workers, respiratory diseases including asthma and allergic rhinitis. Samba (obeche, Triplochiton scleroxylon) is a tropical tree, which grows in West Africa, therefore, Polish workers are rarely exposed to it. This paper describes a case of occupational asthma caused by samba wood dust. Material and Methods: The patient with suspicion of occupational asthma due to wood dust was examined at the Department of Occupational Diseases and Clinical Toxicology in the Nofer Institute of Occupational Medicine. Clinical evaluation included: analysis of occupational history, skin prick tests (SPT) to common and occupational allergens, determination of serum specific IgE to occupational allergens, serial spirometry measurements, metacholine challenge test and specific inhalation challenge test with samba dust. Results: SPT and specific serum IgE assessment revealed sensitization to common and occupational allergens including samba. Spirometry measurements showed mild obstruction. Metacholine challenge test revealed a high level of bronchial hyperactivity. Specific inhalation challenge test was positive and cellular changes in nasal lavage and induced sputum confirmed allergic reaction to samba. Conclusions: IgE mediated allergy to samba wood dust was confirmed. This case report presents the first documented occupational asthma and rhinitis due to samba wood dust in wooden airplanes model maker in Poland.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2014, 27, 3; 512-519
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mannitol vs. methacholine in the evaluation of airway responsiveness in bakers’ asthma
    Autorzy:
    Nowakowska-Świrta, Ewa
    Wiszniewska, Marta
    Lipińska-Ojrzanowska, Agnieszka
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2116654.pdf
    Data publikacji:
    2020-03-13
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    mannitol
    methacholine
    nonspecific bronchial hyper-responsiveness
    occupational asthma
    specific inhalation challenge test
    bakery workers
    Opis:
    ObjectivesVarious indirect or direct airway challenge tests are used to measure nonspecific bronchial hyper-responsiveness (NSBHR). The evaluation of NSBHR in diagnosing occupational asthma (OA) is performed, e.g., to monitor the specific inhalation challenge test (SICT). The aim of this study was to preliminarily compare the results of methacholine and mannitol inhalation challenge tests in SICT monitoring in bakers with work-related airway symptoms.Material and MethodsFour bakery workers with a suspicion of OA underwent single-blind placebo-controlled SICTs involving workplace allergens, accompanied by the evaluation of NSBHR with mannitol and methacholine, both before and after SICTs. Clinical examinations, spirometry tests, skin prick tests (SPTs) to common aeroallergens and occupational allergens, as well as tests to determine serum specific IgE antibodies to occupational aeroallergens were also performed.ResultsPositive SPTs results to occupational aeroallergens were found in all bakery workers, and specific IgE antibodies to flour were detected in 2 subjects. Three patients displayed positive SICT reactions. In all of these 3 patients, airway responsiveness to methacholine increased significantly. In 2 patients, airway reaction to mannitol was significant, whereas in 1 subject there was no increase in NSBHR after mannitol inhalation. The patient with a negative SICT result did not reveal any changes in NSBHR before and after the test, either to methacholine or mannitol.ConclusionsThe data obtained by the authors show that there is no clear correlation between the methacholine and mannitol inhalation challenge tests in SICT monitoring. Preliminary results indicate the need for further investigations to evaluate the usefulness of the mannitol challenge test in the diagnostics of OA.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2020, 33, 2; 235-239
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Occupational exposure to diisocyanates in polyurethane foam factory workers
    Autorzy:
    Świerczyńska-Machura, Dominika
    Brzeźnicki, Sławomir
    Nowakowska-Świrta, Ewa
    Walusiak-Skorupa, Jolanta
    Wittczak, Tomasz
    Dudek, Wojciech
    Bonczarowska, Marzena
    Wesolowski, Wiktor
    Czerczak, Sławomir
    Pałczyński, Cezary
    Powiązania:
    https://bibliotekanauki.pl/articles/2177097.pdf
    Data publikacji:
    2015-08-10
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    biomarkers
    diisocyanates
    asthma
    polyurethanes
    biological monitoring
    occupational exposure
    occupational diseases
    Opis:
    Objectives The aim of the study was to evaluate health effects of occupational exposure to diisocyanates (DIC) among polyurethane foam products factory workers. Material and Methods Thirty workers had a physical examination, skin prick tests with common allergens, allergen-specific immunoglobulin E (IgE) antibodies to diisocyanates and pulmonary function tests. Concentrations of selected isocyanates in the workplace air samples as well as concentration of their metabolites in the urine samples collected from the workers of the plant were determined. Results The most frequent work-related symptoms reported by the examined subjects were rhinitis and skin symptoms. Sensitization to at least 1 common allergen was noted in 26.7% of the subjects. Spirometry changes of bronchial obstruction of a mild degree was observed in 5 workers. The specific IgE antibodies to toluene diisocyanate (TDI) and 4,4’-methylenebis(phenyl isocyanate) (MDI) were not detected in any of the patients’ serum. Cellular profiles of the collected induced sputum (ISP) did not reveal any abnormalities. Air concentrations of TDI isomers ranged 0.2–58.9 μg/m³ and in 7 cases they exceeded the Combined Exposure Index (CEI) value for those compounds. Concentrations of TDI metabolites in post-shift urine samples were significantly higher than in the case of pre-shift urine samples and in 6 cases they exceeded the British Biological Monitoring Guidance Value (BMGV – 1 μmol amine/mol creatinine). We didn’t find a correlation between urinary concentrations of TDI, concentrations in the air and concentrations of toluenediamine (TDA) in the post shift urine samples. Lack of such a correlation may be an effect of the respiratory protective equipment use. Conclusions Determination of specific IgE in serum is not sensitive enough to serve as a biomarker. Estimation of concentrations of diisocyanate metabolites in urine samples and the presence of work-related allergic symptoms seem to be an adequate method for occupational exposure monitoring of DIC, which may help to determine workers at risk as well as to recognize hazardous workplaces.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2015, 28, 6; 985-998
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Work-related respiratory symptoms among health centres cleaners: A cross-sectional study
    Autorzy:
    Lipińska-Ojrzanowska, Agnieszka
    Wiszniewska, Marta
    Świerczyńska-Machura, Dominika
    Wittczak, Tomasz
    Nowakowska-Świrta, Ewa
    Pałczyński, Cezary
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2178854.pdf
    Data publikacji:
    2014-06-21
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    cleaners
    occupational allergy
    work-related respiratory symptoms
    work-related asthma
    WRA
    Opis:
    Objectives: Several studies, mostly based on questionnaire-derived data, have shown an increased risk of allergic diseases, especially asthma, among cleaners. The risk factors and etiological mechanisms are still being investigated. Occupational exposure to various chemical and biological agents may induce specific sensitization and/or irritant effects. The aim of our study was to estimate the prevalence of work-related symptoms suggesting the presence of allergic disease reported by cleaners, and to relate them to the results of commercially available and standardized objective tests used for screening detection of occupational sensitization and chronic respiratory disorders. Material and Methods: A cross-sectional study was performed among 142 Polish workers of cleaning service in their workplaces. A detailed questionnaire, skin prick tests to common allergens and chemicals used by these workers for cleaning purposes (chloramine T, chlorhexidine, formaldehyde, glutaraldehyde, benzalconium chloride), total and specific serum IgE antibodies to disinfectants and rest spirometry were performed in all the subjects. Results: Fifty nine percent of all the subjects declared occurrence of at least 1 symptom suggesting allergic ailment during cleaning activities at work. Skin prick tests and specific serum IgE antibodies to disinfectants were negative in all the subjects. In 8 cases wheezing was detected during auscultation, but only in 5 of them obstructive pattern in rest spirometry was found. Conclusions: Occupational allergic causation of symptoms among cleaners could be less likely than work-related symptoms associated with exacerbations of new-onset or pre-existing respiratory diseases. Therefore, in this group of workers, mainly the non-specific irritant impact of chemicals on airways should be taken into consideration.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2014, 27, 3; 460-466
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena nadreaktywności oskrzeli i jej zastosowanie w diagnostyce astmy związanej z pracą
    The usefulness of bronchial challenge tests in the diagnosis of occupational asthma
    Autorzy:
    Nowakowska-Świrta, Ewa
    Wiszniewska, Marta
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2162489.pdf
    Data publikacji:
    2018-08-20
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    astma
    nadreaktywność oskrzeli
    oskrzelowe testy prowokacyjne
    zapalenie w drogach oddechowych
    alergia zawodowa
    medycyna pracy
    asthma
    bronchial hyperreactivity
    bronchial challenge test
    airway inflammation
    occupational allergy
    occupational medicine
    Opis:
    Nadreaktywność oskrzeli (bronchial hyperresponsiveness – BHR) to osobnicza zdolność do ich reakcji skurczowej na różne bodźce swoiste i nieswoiste, które u zdrowej osoby nie wywołują takiej odpowiedzi. Nadreaktywność oskrzeli jest jedną z cech charakterystycznych astmy. Stopień nadreaktywności oskrzeli jest różny u osób z tą chorobą i koreluje z jej ciężkością (im cięższy przebieg astmy, tym większa nadreaktywność oskrzeli). Do wykrywania i pomiaru BHR służą wziewne testy prowokacyjne, w których wykorzystuje się czynniki fizyczne i chemiczne. Testy te podzielono – w zależności od ich mechanizmu działania – na bezpośrednie i pośrednie. Testy bezpośrednie są niezwykle czułe i mają zastosowanie głównie w diagnostyce wykluczającej astmę. Prowokacje z czynnikami pośrednimi są natomiast mniej precyzyjne, ale bardziej swoiste w porównaniu z testami bezpośrednimi. Wykorzystuje się je przede wszystkim do potwierdzenia rozpoznania astmy i lepszego wnioskowania o zmianach zapalnych u chorego. Testy nadreaktywności oskrzeli odgrywają ważną rolę w medycynie pracy. W określonych przypadkach powinny być wykonywane podczas badań wstępnych pracowników przed ich zatrudnieniem, w trakcie badań okresowych, w diagnostyce i monitorowaniu astmy zawodowej oraz astmy nasilającej się w pracy. W artykule opisano wybrane oskrzelowe testy prowokacyjne oraz ich zastosowanie w diagnostyce astmy związanej z pracą. Med. Pr. 2018;69(4):457–471
    Bronchial hyperresponsiveness (BHR) is the individual ability to respond with bronchoconstriction to a variety of specific and nonspecific stimuli which do not cause these symptoms among healthy subjects. Bronchial hyperresponsiveness is one of the hallmark features of asthma. The degree of bronchial hyperresponsiveness is variable among individuals with asthma and may correlate to its severity (the more severe asthma the higher bronchial hyperreactivity). Bronchial hyperresponsiveness is evaluated by performing bronchial provocation test (BPT). Provocation tests are classified – according to their mechanisms – into direct and indirect tests. Direct challenge tests are highly sensitive and they are used primarily to rule out asthma. In contrast, provocation tests with indirect stimuli are less sensitive but more specific to the direct tests; they are used generally to confirm the diagnosis of asthma and they allow for more accurate conclusions about inflammatory lesions in the case of a patient. Bronchial provocation tests play a significant role in occupational medicine. They are particularly relevant to be performed prior to employment, during periodic examinations, and to diagnose and monitor both occupational asthma and work-related asthma. This article presents selected bronchial provocation tests and their usefulness in the diagnosis of occupational asthma. Med Pr 2018;69(4):457–471
    Źródło:
    Medycyna Pracy; 2018, 69, 4; 457-471
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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