- Tytuł:
- The mystery of reactive oxygen species derived from cell respiration.
- Autorzy:
-
Nohl, Hans
Gille, Lars
Staniek, Katrin - Powiązania:
- https://bibliotekanauki.pl/articles/1043351.pdf
- Data publikacji:
- 2004
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
hydrogen peroxide
reactive oxygen species
mitochondria
phospholipid membrane
superoxide
bc1 complex - Opis:
- Mitochondrial respiration is considered to provide reactive oxygen species (ROS) as byproduct of regular electron transfer. Objections were raised since results obtained with isolated mitochondria are commonly transferred to activities of mitochondria in the living cell. High electrogenic membrane potential was reported to trigger formation of mitochondrial ROS involving complex I and III. Suggested bioenergetic parameters, starting ROS formation, widely change with the isolation mode. ROS detection systems generally applied may be misleading due to possible interactions with membrane constituents or electron carriers. Avoiding these problems no conditions reported to transform mitochondrial respiration to a radical source were confirmed. However, changing the physical membrane state affected the highly susceptible interaction of the ubiquinol/bc1 redox complex such that ROS formation became possible.
- Źródło:
-
Acta Biochimica Polonica; 2004, 51, 1; 223-229
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł