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Wyświetlanie 1-12 z 12
Tytuł:
Selenium – meaning in the prevention and therapy of cancer diseases
Selen – znaczenie w profilaktyce i terapii schorzeń nowotworowych
Autorzy:
Molenda, Anita
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1033700.pdf
Data publikacji:
2017
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Selol
anticancer activity
selenium compounds
Opis:
Selenium is a trace element supplied to the human body with food of plant and animal origin. It is a component of many enzymes with antioxidant activity, such as: glutathione peroxidase, seleniumprotein P, thioredoxin reductase and phospholipid hydroperoxide glutathione peroxidase. Being a component of enzymes, it protects cells against deformation and genetic damage thanks to the properties that inhibit the processes of lipid peroxidation, nucleic acids (DNA, RNA). The human body contains about 10-15 mg of selenium, 60% of which is found in erythrocytes, and 40% in blood. The problem of Poland and neighboring countries is the lack of this element in the soil, and therefore in the organisms of herbivorous farm animals. The lack of selenium in the meat of these animals causes significant deficiencies in the human body. In addition, due to the lack of this element in the soil, vegetables and preparations obtained from it do not constitute a suitable dietary source and intensify the problem of deficiency of this element in Europeans. Many studies indicate that both organic and inorganic selenium compounds reduce the progression of cancer by reducing the migration of cancer cells, inhibiting angiogenesis, and consequently reduce metastases.
Źródło:
Medicina Internacia Revuo; 2017, 28, 109; 272-279
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Natural products in dentistry
Surowce naturalne w stomatologii
Autorzy:
Pytko-Polonczyk, Jolanta
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1033719.pdf
Data publikacji:
2016
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"ether oils"
"eugenol"
"flavonoids"
"natural products in dentistry"
"zinc"
Opis:
Modern medicine used many methods of treatment; one of them is phytotherapy. It is documented that plants can not only prevent many diseases, but also cure diseases. Main activities of plant materials used in dentistry are anti-inflammatory, antibacterial, antiviral, decongestant, adtringent, anti-bleeding and regenerating. The natural materials used in dentistry are mainly in the form of lotions, tinctures, infusions, toothpaste, drops and gels. The most important group of active compounds in dental formulations of natural origin include essential oils, monoterpenoides, phenolic compounds, gums, resins, tannins, flavonoids, anthocyanins, carotenoids, chlorophyll, vitamins, elements such as especially zinc and minerals such as AlK(SO4)2. It occurs naturally and is used for control of bleeding, and as an antiseptic. The ideal antimicrobial agent should be effective in removing bacteria responsible for the periodontal disease process; to have the widest possible range of action, does not cause side effects and have a prolonged activity in the oral cavity. Accordingly natural products particularly as essential oils and phenol compounds can, fulfill these tasks.
Źródło:
Medicina Internacia Revuo; 2016, 27, 107; 68-75
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biologically active compounds from selected aphyllophorales mycelial cultures
Autorzy:
Sułkowska-Ziaja, Katarzyna
Muszyńska, Bożena
Firlej, Anna
Powiązania:
https://bibliotekanauki.pl/articles/765035.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
Basidiomycota
indole compounds
phenolic acids
sterols
Opis:
Grzyby z gromady Basidiomycota od dawna budzą zainteresowanie ze względu na występowanie w ich owocnikach szeregu związków o uznanych właściwościach leczniczych. Obiektem przeprowadzonych badań były kultury mycelialne dwóch gatunków grzybów afylloforoidalnych występujących na terenie Polski Hydnum repandum L. oraz Sparassis crispa (Wulf.) Fr. Celem podjętych badań była jakościowa i ilościowa analiza ekstraktów otrzymanych z kultur mycelialnych pod kątem występowania związków o udokumentowanej aktywności biologicznej: kwasów fenolowych, niehalucynogennych związków indolowych oraz steroli. Do oznaczeń wykorzystano wysokosprawną chromatografię cieczową faz odwróconych (RP-HPLC). Na podstawie analizy stwierdzono w ekstraktach z otrzymanej biomasy obecność ośmiu kwasów fenolowych: galusowego, gentyzynowego, p-hydroksybenzoesowego, kawowego, kumarowego, protokatechowego, syryngowego, wanilinowego oraz kwasu cynamonowego. Ilościowo dominującym związkiem był kwas protokatechowy w ilości 6,23 μg/g s.m. (H. repandum) oraz kwas hydroksybenzoesowy w ilości 4,52 μg/g s.m. (S. crispa). Spośród związków pochodnych indolu ilościowo oznaczono: indol, serotoninę, tryptaminę i tryptofan. Całkowita ich zawartość wynosiła 1,28 μg/g s. m. (ekstrakty z H. repandum) oraz 3,07 μg/g s.m. (ekstrakty z S.crispa). Ilościowo dominującym metabolitem był tryptofan. Spośród steroli oznaczono ergosterol w biomasie z kultur in vitro S. crispa (700,87 μg/g s.m). Uzyskane wyniki wskazują, że przebadane kultury mycelialne krajowych gatunków grzybów afylloforoidalnych są zdolne do akumulacji metabolitów aktywnych biologicznie.  
For a long time fungi belonging to Basidiomycota phylum have been in the center of attention because of the presence in their fruiting bodies of compounds with known therapeutic activity. Mycelial cultures of two aphyllophorales species occurring in Poland, Hydnum repandum L., and Sparassis crispa (Wulf.) Fr., were analyzed in our study. The main aim of the study was qualitative and quantitative analysis of extracts obtained from the mycelial cultures for the presence of known biologically active compounds, including phenolic acids, non-hallucinogenic indole compounds and sterols. For analyses a reversed-phase chromatography (RP-HPLC) method was used. The presence of eight phenolic acids including gallic, gentisic, p-hydroxybenzoic, caffeic, p-coumaric protocatechuic, syringic, vanillic and cinnamic acids was confirmed in the extracts obtained from the biomass. The quantitatively predominant metabolites in biomass from in vitro cultures of H. repandum and S. crispa were protocatechuic acid (6.23 μg/g DW) and p-hydroxybenzoic acid (4.52 μg/g DW). Derivatives of indole such as indole, serotonin, tryptamine and tryptophan were measured quantitatively. Their total content was estimated as 1.28 μg/g DW and 3.07 μg/g DW in H. repandum and S. crispa extracts, respectively. The major metabolite found was tryptophan. In addition, ergosterol, one of the sterols present in the biomass of in vitro cultures of S. crispa was analyzed (700.87 μg/g DW). The obtained results confirm the hypothesis that mycelial cultures of domestic species of aphyllophorales are able to accumulate biologically active metabolites. 
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2014, 10; 73-79
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Karotenoidy rola biologiczna i występowanie w owocnikach grzybów
Biological function of carotenoids and their occurrence in the fruiting bodies of mushrooms
Autorzy:
Muszyńska, Bożena
MASTEJ, Małgorzata
SUŁKOWSKA – ZIAJA, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1033726.pdf
Data publikacji:
2016
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"antioxidant activity"
"carotenoids"
"edible mushrooms"

β-carotene"
Opis:
Due to the valuable properties of carotenoidsthe interest in new methods of obtaining them is still increasing. For this purpose, since the 60s of the twentieth century, scientists conducted numerous studies to recognize the processes in which carotenoids could be produced . Carotenoids, revealing a strong antioxidant activity, act as free radical scavengers. These compounds can support many beneficial processes such as the stimulation of the immune system, the modulation of intracellular signaling pathways, the regulation of the cell cycle and apoptosis as well as theregulation of growth factors. Carotenoids were determined by spectrophotometric analysis in the following fungal species: Leucopaxillus giganteus, Sarcodon imbricatus, Lactarius piperatus, Lactarius deliciosus, Agaricus arvensis, Agaricus bisporus, Agaricus romagnesii, Agaricus silvaticus, Agaricus silvicola, Hypholoma fasciculare, Calocybe gambosa, Craterellus cornucopioides, Marasmius oreades. High performance liquid chromatography (HPLC) coupled with a UV detector detected β,β-carotene in Agaricus bisporus, Polyporus squamosus, Lepista nuda, Russula delica, Verpa conica, Pleurotus ostreatus and Hypsizgus marmoreus. β-carotene and lycopene were also found in three wild species of edible mushrooms: Leucopaxillus giganteus, Sarcodon imbricatus and Agaricus arvensi. These compounds were isolated in several species of the family Cantharellus as well. One example is Cantharellus cibarius, which contains mainly β,β-carotene and minor amounts of lycopene, α-carotene and other carotenoids, which may be δ – and γ – isomers.
Źródło:
Medicina Internacia Revuo; 2016, 27, 107; 113-122
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Culinary and medicinal mushrooms: insight into growing technologies
Autorzy:
Zięba, Piotr
Sękara, Agnieszka
Sułkowska-Ziaja, Katarzyna
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/11543379.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
mushroom
mushroom cultivation
growing technology
Agaricus bisporus
Ganoderma lucidum
Lentinus edodes
Pleurotus
polysaccharide
terpenoid
cultivated mushroom
medicinal property
edible mushroom
Opis:
Humans have used mushrooms from the beginning of their history. However, during the last few decades, the market demand for these fruiting bodies has increased significantly owing to the spread in the capabilities of culinary and pharmacological exploitation. Natural mushroom resources have become insufficient to meet the support needs. Therefore, traditional methods of extensive cultivation as well as modern technologies have been exploited to develop effective growing recommendations for dozens of economically important mushroom species. Mushrooms can decompose a wide range of organic materials, including organic waste. They play a fundamental role in nutrient cycling and exchange in the environment. The challenge is a proper substrate composition, including bio-fortified essential elements, and the application of growing conditions to enable a continuous supply of fruiting bodies of market quality and stabilized chemical composition. Many mushroom species are used for food preparation. Moreover, they are treated as functional foods, because they have health benefits beyond their nutritional value, and are used as natural medicines in many countries. Owing to the rapid development of mushroom farming, we reviewed the growing technologies used worldwide for mushroom species developed for food, processing, and pharmacological industries.
Źródło:
Acta Mycologica; 2020, 55, 2; 5526
0001-625X
2353-074X
Pojawia się w:
Acta Mycologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Grzyby nadrewnowe z rodzaju Ganoderma źródłem biologicznie aktywnych triterpenów
Wood Decay Mushrooms of The Genus Ganoderma as A Source of Biologically Active Triterpenes
Autorzy:
Sułkowska-Ziaja, Katarzyna
Piechaczek, Małgorzata
Pacławska, Aneta
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1033575.pdf
Data publikacji:
2017
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Ganoderma sp.
anti-inflammatory
antitumor
terpenoids
Opis:
Species of the genus Ganoderma are an example of some of the most thoroughly studied representatives of Basidiomycota both in terms of chemical composition and biological activity. Among the compounds found in this kind, the therapeutic effect is primarily associated with the polysaccharides that are heteroglycans or β-D-glucans and terpenoids represented mainly by triterpenes. Triterpene compounds have a structure composed of 30 carbon atoms, usually forming a system of five six-membered rings. Characteristic of these structures are functional groups (hydroxyl, carboxyl or ketone) and double bonds. Mycochemical studies have led to the isolation of numerous triterpenes of the lanostane type (ganoderic acids, aldehydes, alcohols, esters), lucidenic acids and others from various species of the Ganoderma genus. The broad spectrum of biological activity determined by triterpene compounds includes anti- tumor, anti-inflammatory, antioxidant, hepatoprotective, antidiabetic, and antiviral effects. This work describes biologically active triterpenes in selected species of the genus Ganoderma: Ganoderma lucidum, Ganoderma applanatum, Ganoderma adspersum, Ganoderma pfeifferi, Ganoderma colossum and others. These species are sources of natural compounds valued for thousands of years in the traditional medicine of the Far East, while ongoing research has confirmed their medicinal properties nowadays.
Źródło:
Medicina Internacia Revuo; 2017, 28, 109; 237-245
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
EVALUATION OF NUTRITIONAL AND MEDICINAL PROPERTIES OF BACOPA MONNIERI BIOMASS AND PREPARATIONS
Autorzy:
Muszyńska, Bożena
krakowska, Agata
Lazur, Jan
Szewczyk, Agnieszka
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/895242.pdf
Data publikacji:
2018-12-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
dietary supplements
phenolic compounds
Bacopa monnieri
artificial digestive juices
bioelements
Opis:
Bacopa monnieri (Scrophulariaceae) is a well-known plant and has been used by humans for several thousand years. In traditional Hindu medicine, it is one of the most important medicinal plants. The aim of the work was to determine the content of Fe, Mg, and Zn and selected organic compounds before and after extraction into the artificial digestive juices obtained from preparations containing B. monnieri. Commercial preparations in the form of tablets and capsules and B. monnieri shoot cultures were used in the experiment. The metal content in the considered mineralized samples was analyzed by atomic absorption spectrometry and organic compounds by RP-HPLC method. The maximum measured content of the metals released into the digestive juices was as follows: Fe – 32.85; Mg – 367.51; and Zn – 16.41 mg/100 g of the preparation. The existing research shows that metals are best released into the artificial digestive juices from the B. monnieri shoot cultures, and least efficiently from the commercial preparations available in the form of tablets. The phenolic compounds analyzed in the methanol extracts and the extracts of the artificial digestive juices were as follows: protocatechuic acid, p-hydroxybenzoic acid, neochlorogenic acid, chlorogenic acid, isochlorogenic acid, caffeic acid, ferulic acid, cynaroside, trifolin, and luteolin. Bacoside A was only determined in the extracts from the B. monnieri shoot cultures. The experimental results revealed that B. monnieri distributed in the form of tablets did not break down in the artificial digestive juices during the considered time intervals.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1353-1361
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of indole derivatives in methanolic extracts from mycelium of Agaricus bisporus cultured in vitro on liquid Oddoux medium
Autorzy:
Muszyńska, Bożena
Sułkowska-Ziaja, Katarzyna
Hałaszczuk, Patrycja
Krężałek, Remigiusz
Łojewski, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/765001.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
Agaricus bisporus
in vitro culture
L-tryptophan
serotonin
Opis:
Lecznicze i przeciwutleniające właściwości grzybów są doskonałym połączeniem, które stanowi o ich wartości dietetycznej i umożliwia korzystanie z nich zarówno, jako żywności jak i dodatku żywieniowego. Celem niniejszej pracy była analiza zawartości fizjologicznie aktywnych związków indolowych w mycelium z kultur in vitro Agaricus bisporus (pieczarka dwuzarodnikowa). L-tryptofan, egzogenny aminokwas i jego pochodne, takie jak np. 5-hydroksytryptofan, muszą być dostarczane z pokarmem w codziennej diecie. Związki te mają działanie przeciwdepresyjne, są bezpośrednimi prekursorami serotoniny, a w przeciwieństwie do niej przekraczają barierę krew – mózg. Są też biogenetycznymi prekursorami innych związków indolowych, które pełnią funkcję neuroprzekaźników, co uzasadnia oznaczanie ich zawartości w grzybach jadalnych. Materiał do badań stanowiły owocniki A. bisporus pochodzenia komercyjnego. Z owocników A. bisporus wyprowadzono kultury in vitro na podłożu stałym Oddoux (1957). Eksperymentalne kultury in vitro prowadzono na płynnym, wytrząsanym podłożu Oddoux. Co dwa tygodnie prowadzenia kultur pasażowano je na świeżą pożywkę. Biomasę mrożono i suszono metodą liofilizacji. Otrzymaną biomasę z kultur in vitro analizowano jakościowo i ilościowo metodą HPLC na obecność niehalucynogennych związków indolowych. Po raz pierwszy zidentyfikowane i ilościowo oznaczone zostały związki indolowe w kulturach in vitro Agaricus bisporus na płynnym podłożu wg Oddoux. Analiza wykazała, że ekstrakty metanolowe otrzymane z grzybni zawierają sześć związków indolowych: L -tryptofan, 5 - hydroksytryptofan, serotoninę, melatoninę, tryptaminę i 5-metylotryptamię. Zawartości poszczególnych składników w biomasie z kultur in vitro były zróżnicowane w zakresie od 0,01 do 21,33 mg/100 g s. m. Dominującymi ilościowo związkami były: 5-hydroksytryptofan (12,50 mg/100 g s. m.), L-tryptofan (14,00 mg/100 g) i serotonina (7,00 mg/100 g). Całkowita zawartość związków indolowych w badanym materiale wynosiła 55,32 mg/100 g s. m. Biomasa z kultur in vitro badanego gatunku jest dobrym źródłem 5-hydroksytryptofanu i L- tryptofanu. Kultury in vitro A. bisporus mogą być wykorzystane jako model do badań nad akumulacją i metabolizmem związków indolowych.
Methanolic extracts obtained from biomass of Agaricus bisporus (J.E. Lange) Imbach cultured in vitro were analyzed for qualitative and quantitative composition of non-hallucinogenic indole compounds in order to compare their amount with fruiting bodies of these species. Extracts demonstrated to contain six indole compounds. Contents of individual compounds ranged from 0.01 to 21.33 mg/100 g d.w. in biomass from in vitro cultures. The quantitatively dominating compounds included: 5-hydroxytryptophan (12.50 mg/100 g d.w.), L-tryptophan (14.00 mg/100 g d.w.) and serotonin (7.00 mg/100 g d.w.). Total content of the remaining indole compounds under analysis in the study was 55.32 mg/100 g d.w.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2014, 10; 66-72
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-inflammatory activities of garlic sprouts, a source of α-linolenic acid and 5-hydroxy-l-tryptophan, in RAW 264.7 cells
Autorzy:
Gdula-Argasińska, Joanna
Paśko, Paweł
Sułkowska-Ziaja, Katarzyna
Kała, Katarzyna
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1038621.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Allium sativum sprouts
indolic and phenolic compounds
α-linolenic acid
anti-inflammatory activity
RAW 264.7 cells
Opis:
The purpose of this study was to analyze the indolic, phenolic, and fatty acid content and antioxidant activity of garlic sprouts growing in the dark and in the daylight. The pro- or anti-inflammatory properties of the garlic sprout extract were investigated by evaluating the cyclooxygenase-2 (COX-2), prostaglandin E synthase (cPGES), glutathione S transferase (GSTM1), nuclear factor NF-κB, peroxisome proliferator-activated receptors (PPARs), and aryl hydrocarbon receptor (AhR) protein levels in the RAW 264.7 cells activated with lipopolysaccharide (LPS). The highest amount of total indolic (73.56 mg/100 g f.w.) and phenolic compounds (36.23 mg/100 g f.w.) was detected in garlic sprouts grown in the daylight. Studies on antioxidant activity (the FRAP and DPPH method) of garlic sprouts showed that this activity is significantly higher for sprouts grown in full access to light when compared to those grown in the dark. In garlic sprout extracts, α-linolenic acid (ALA) was found to be in greater amount. COX-2 and cPGES level was lower when compared to LPS alone activated cells. After garlic extract treatment, higher level of GSTM1, PPARΥ, cytosolic p50 and p65 protein, as well as a lower NF-ĸB p50/p65 activity was noted in the RAW 264.7 cells which suggested PPARs and AhR transrepression mechanism of NF-ĸB signalling. The obtained results indicate Allium sativum sprouts are a rich source of n-3 fatty acids, indolic and phenolic compounds characterized by anti-inflammatory and antioxidative activity, which may support their high therapeutic and dietary potential.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 551-559
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of the content of phenolic compounds in in vitro culture of some edible mushrooms (Basidiomycota)
Autorzy:
Muszyńska, Bożena
Kała, Katarzyna
Sułkowska-Ziaja, Katarzyna
Szewczyk, Agnieszka
Łojewski, Maciej
Rojowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1033831.pdf
Data publikacji:
2015
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
agaricus bisporus
boletus badius
cantharellus cibarius
medicinal mushroom
phenolic
acids
Opis:
Phenolic compounds, both derivatives of benzoic and cinnammic acid, possess biologically valuable properties: anti-inflammatory, antioxidant, anticarcinogenic and others. Studies of the accumulation of these compounds focused mostly on plant material. Rich sources of these compounds are representatives of Basidiomycota taxon. The aim of the study was qualitative and quantitative HPLC analysis of phenolic acids in biomass from in vitro culture of selected edible mushroom species belonging to the phylum Basidiomycota: Agaricus bisporus, Boletus badius, Cantharellus cibarius. The investigations revealed the presence of the following acids: p-hydroxybenzoic, syringic and galic acid. Both the composition and the amount of phenolic acids in biomass of A. bisporus and Boletus badius were diverse. The total amount ranged from 6.07 mg·100 g−1 DW in A. bisporus to 14.78 mg·100 g−1 DW in Boletus badius. Syryngic acid amounts fluctuated in the range of 1.75–9.66 mg·100 g−1 DW, with its maximum in Boletus badius. Gallic acid dominated in the biomass of the same species (5.12 mg·100 g−1 DW). p-Hydroxybenzoic acid was found in biomass from in vitro culture of A. bisporus at levels 0.70 mg/100 g DW. In biomass of in vitro culture of Cantharellus cibarius no phenolic compounds were found before and after hydrolysis. The results of HPLC analyses show that in vitro culture of B. badius and A. bisporus are a good dietary source of phenolic compounds with antioxidant activity.
Źródło:
Medicina Internacia Revuo; 2015, 26, 104; 146-152
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
Autorzy:
Grzywacz, Agata
Gdula-Argasińska, Joanna
Muszyńska, Bożena
Tyszka-Czochara, Małgorzata
Librowski, Tadeusz
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1038990.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
metal responsive-transcription factor 1
cell signaling
inflammation
NF-κB
Opis:
Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 491-498
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
RELEASE OF BIOACTIVE SUBSTANCES FROM FORMULATIONS CONTAINING ARTHROSPIRA PLATENSIS (SPIRULINA PLATENSIS)
Autorzy:
Muszyńska, Bożena
Lazur, Jan
Jękot, Barbara
Krakowska, Agata
Szewczyk, Agnieszka
Sułkowska-Ziaja, Katarzyna
Zimmer, Łukasz
Poleszak, Ewa
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/895358.pdf
Data publikacji:
2018-10-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
zinc
phenolic compounds
artificial digestive juices
Arthrospira platensis
indole compounds
Opis:
Arthrospira platensis (Spirulina platensis) is a well-known microalga and has been utilized as a medicinal agent and foodstuff by humans since at least 16th century. The aim of this study was to determine zinc content as well as determine phenolic and indole compounds from commercial preparations containing Arthrospira platensis (lyophilizate, tablets, and capsules) before and after extraction with methanol and incubation with artificial digestive juices. The secondary aim of this study was to evaluate the quality of these preparations. The samples were incubated in artificial stomach juice and in intestinal juice. The samples were mineralized and their zinc(II) ions content was estimated using flame absorption atomic spectroscopy (F-AAS). The maximum zinc(II) ions content released into the digestive juices was found to be up to 1.6 mg 100 g-1 of the preparation. Phenolic compounds identified in the examined extracts are as follows: gallic acid; protocatechuic acid; 3,4-dihydroxyphenylacetic acid; p-hydroxybenzoic acid; syringe acid; cinnamic acid; and quercetin. Furthermore, indole compounds identified were 5-hydroxy-L-tryptophan, 5-methyl-L-tryptophan, L-tryptophan, tryptamine, and 5-methyltryptamine. Consequently, it was also found that the distributed Arthrospira platensis in the form of tablets does not disintegrate in the artificial digestive juices. Among the examined preparations, only hard capsules met the requirements of the European Pharmacopeia 8th ed.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1187-1199
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
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