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    Wyświetlanie 1-2 z 2
    Tytuł:
    Witamina C w medycynie i kosmetologii
    Vitamin C in medicine and cosmetology
    Autorzy:
    Musiał, Claudia
    Sawczuk, Wojciech
    Gawdzik, Barbara
    Kuban-Jankowska, Alicja
    Przychodzeń, Paulina
    Górska-Ponikowska, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/172737.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    kwas askorbinowy
    antyoksydant
    farmakoprewencja nowotworu
    wolne rodniki
    pochodne witaminy C
    ascorbic acid
    antioxidant
    cancer pharmacoprevention
    free radicals
    vitamin C derivatives
    Opis:
    Ascorbic acid is one of the strongest antioxidants. It has a protective function against oxidative stress intracellularly. It fights free radicals and eliminates the effects of ultraviolet radiation. The human body is unable to synthesize vitamin C itself. Vitamin C meets supports the mechanism of removing toxins from the human body and has anticancer activity. Over the years, many studies have been carried out to confirm the beneficial effect of preventive and supportive action of cytostatics in the treatment of cancer. Clinical studies described in the study indicate that vitamin C used in combination with a cytostatic drug - gemcystabine, shows no side effects. Vitamin C applied topically on the skin shows a number of positive effects. Studies have shown that vitamin C accumulates in the deeper layers of the skin for about three days. Ascorbic acid has a protective effect against harmful ultraviolet radiation. Manufacturers of cosmetics often add ascorbic acid to cosmetics with sunscreens. In addition, vitamin C acts depigmenting. In order to increase the brightening effect, vitamin C is often combined with glycolic acid or retinol. Ascorbic acid is also used in anti-aging preparations due to the high ability of collagen synthesis in the skin. In topical preparations, ascorbic acid has hydrophilic properties - it is soluble in water and insoluble in fats. Hydrophilic ascorbic acid in synergy with lipophilic tocopherol reduces cell apoptosis and thymine dimer formation. Its stability improves the presence of stabilizing antioxidants, such as vitamin E and ferulic acid. For the preparation to retain its properties, it should be protected from light and oxygen. The development of biotechnology allows the closure of a micronised vitamin C in nanosomes and liposomes, which increases the ability to penetrate deep into the skin. A number of vitamin C derivatives such as ascorbyl tetrapalmitate and ascorbyl phosphate magnesium help achieve the desired results in topical application.
    Źródło:
    Wiadomości Chemiczne; 2019, 73, 9-10; 503-522
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biologia i chemia nowotworu płuca
    Biology and chemistry of lung cancer
    Autorzy:
    Musiał, Claudia
    Zaucha, Renata
    Kuban-Jankowska, Alicja
    Kamm, Anna
    Górska-Ponikowska, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/972293.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    farmakoprewencja raka płuca
    biologia raka płuca
    chemia raka płuca
    indukcja hormonalna
    2-metoksyestradiol
    lung cancer pharmacoprevention
    biology of lung cancer
    chemistry of lung cancer
    hormonal induction
    2-methoxyestradiol
    Opis:
    Lung cancer is the most common fatal cancer disease in the world. A characteristic feature of lung cancer is genetic diversity. In the overwhelming majority of cases, smoking is the most important etiopathogenic factor. Lung cancer is a cancer with a very bad prognosis regarding long-term survival. The risk of lung cancer depends primarily on active or passive exposure to the carcinogenic components of tobacco smoke. According to available data, the development of lung cancer in addition to active and passive smoking is directly affected by environmental pollution such as smog and fumes, ionizing radiation, mycotoxins and long-term exposure to asbestos (occupational exposure). Research on the pharmacoprevention of lung cancer began over 30 years ago. The first nutrient that the researchers said could inhibit the development of lung cancer was beta carotene. Unfortunately, long-term regular supplementation with high doses of antioxidant in the form of beta-carotene brought the opposite effect. An increase in the incidence of lung cancer was found in people who received beta carotene in the form of a synthetic food supplement. The other component tested was N-acetylcysteine. It is a sulfur compound and a powerful antioxidant that supports the synthesis of glutathione and cysteine, with destructive effects on carcinogenic substances. N-acetyl-cysteine, used in the form of NAC adduct and epigallocatechin-3-gallate, showed efficacy in inhibiting the development of lung cancer only in animal models. In the pharmacoprevention of lung cancer, the use of vitamin E was also tested in the form of tocotrienol and tocopherol. The following work also shows the existence of a high concentration correlation which belongs to the steroid hormone, mainly estrogen, in the blood and the development of lung cancer in women. An increased risk of lung cancer has been observed in women undergoing long-term hormone replacement therapy. The results show that 2-methoxyestradiol, the endogenous metabolite of 17ß-estradiol, shows positive results that inhibit the growth of lung cancer cell lines. The aim of the work was to present the correlation between tobacco abuse and passive smoking and lung cancer, pharmacoprevention of lung cancer and the association of elevated estrogen concentration in women with an increased risk of lung cancer.
    Źródło:
    Wiadomości Chemiczne; 2019, 73, 7-8; 505-522
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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