- Tytuł:
- Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.
- Autorzy:
-
Drzewiecka, Agnieszka
Urbańska, Krystyna
Matuszak, Zenon
Pineiro, Marta
Arnaut, Luis
Habdas, Jan
Ratuszna, Alicja
Stochel, Grażyna - Powiązania:
- https://bibliotekanauki.pl/articles/1044198.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
melanoma
porphyrins
photodynamic therapy - Opis:
- We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off <630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm2 dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 1; 277-282
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł