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    Wyświetlanie 1-3 z 3
    Tytuł:
    Preparation and characterization of drug delivery carriers for local administration of sodium alendronate
    Autorzy:
    Posadowska, U.
    Moreira, A.
    Martins, R.
    Pamuła, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/284303.pdf
    Data publikacji:
    2013
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    nanocarriers
    microcarriers
    poly(lactide-co-glycolide) (PLGA)
    osteoporosis
    controlled drug delivery
    sodium alendronate
    Opis:
    Osteoporosis is often treated with the use of sodium alendronate - a drug that inhibits osteoclast-mediated bone resorption and regulates rate of bone turnover. However the disadvantage of oral administration of sodium alendronate is poor drug absorption from the gastrointestinal track and severe adverse effects. Therefore we propose local sustained drug delivery systems based on poly(lactide-co-glycolide) (PLGA) micro- and nanocarriers, which can be administered directly by simple injections to the required place in the body. In this study we encapsulated sodium alendronate into PLGA micro- and nanospheres via a double-emulsification technique. Emulsion formation in different shear rate conditions was used to optimize the size of the carriers. The prepared microspheres were observed under an inverted optical microscope which confirmed their micrometric size. The nanospheres were analyzed by atomic force microscopy, which allowed visualization of their shape and measurement of their size. Moreover the hydrodynamic diameter of the nanospheres, polydispersity index as well as zeta potential were examined by dynamic light scattering. The experiments show that drug release does not depend on the size of the carriers. Analyzed carriers do not cause cytotoxicity upon contact with osteoblast like-cells.
    Źródło:
    Engineering of Biomaterials; 2013, 16, 119; 8-12
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Substrate Temperature Influenced Structural and Electrical Behaviour of~RF Magnetron Sputtered $Ag_2Cu_2O_3$ Films
    Autorzy:
    Sreedhar, A.
    Hari Prasad Reddy, M.
    Uthanna, S.
    Martins, R.
    Elangovan, E.
    Pierson, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/1492600.pdf
    Data publikacji:
    2011-12
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    71.20.-b
    71.15.Mb
    78.20.Ci
    74.25.Gz
    Opis:
    $Ag_2Cu_2O_3$ films were deposited on glass and silicon substrates by RF magnetron sputtering of metallic equimolar $(Ag_{50}Cu_{50})$ alloy target in $Ar-O_{2}$ mixture at different substrate temperature $(T_{s})$ ranging between 303 and 523 K. The effect of $T_{s}$ on the core level binding energies, structural and electrical properties of the films was systematically studied. The films deposited at room temperature were amorphous. The films deposited at 373 K were polycrystalline and the crystallinity was increased when the $T_{s}$ was increased to 423 K. The films deposited at 423 K and subsequently annealed at 498 K exhibits single phase $Ag_2Cu_2O_3$. In the case of films deposited at higher $T_{s}$ of 523 K, $Ag_2O$ was decomposed into Ag. The electrical resistivity of the films deposited at 303 K was $1.2 \times 10^{-5}$ Ω cm, whereas the films formed at 423 K and subsequently annealed at 498 K showed electrical resistivity of $2.2 \times 10^{-3}$ Ω cm due to improvement in the crystallinity of single phase $Ag_2Cu_2O_3$.
    Źródło:
    Acta Physica Polonica A; 2011, 120, 6A; A-037-A-039
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Structural and Optical Behaviour οf~Ni Doped CdS Nanoparticles Synthesized by Chemical Co-Precipitation Method
    Autorzy:
    Siva Kumar, K.
    Divya, A.
    Sreedhara Reddy, P.
    Uthanna, S.
    Martins, R.
    Elangovan, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/1492639.pdf
    Data publikacji:
    2011-12
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    61.05.Cp
    61.72.-y
    78.55.Et
    78.67.Bf
    Opis:
    Pure and Ni (2 at.%) doped cadmium sulfide (CdS) nanoparticles have been synthesized by chemical co-precipitation method at room temperature. Effect of Ni doping on CdS compound semiconductors has been analyzed using X-ray diffractometer, transmission electron microscope, energy dispersive spectroscopy, Raman and optical absorption studies. X-ray diffraction study confirmed the structure of the obtained nanoparticles to be single-phase zinc blende with the diffractions from (111), (220) and (311) planes. Energy dispersive spectroscopy study confirmed the presence of Ni in the CdS lattice. The average particle size obtained from the transmission electron microscopy studies are in agreement with the crystallite size calculated from X-ray diffraction data. The optical studies exhibited a clear red shift of absorption edge as a function of Ni doping.
    Źródło:
    Acta Physica Polonica A; 2011, 120, 6A; A-052-A-054
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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