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    Wyświetlanie 1-5 z 5
    Tytuł:
    Polish Artificial Heart - new coatings, technology, diagnostics
    Autorzy:
    Sarna, J.
    Kustosz, R.
    Major, R.
    Lackner, J.
    Major, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/200025.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    pulsed laser deposition
    microstructure
    cell adhesion
    Opis:
    Since 1991, the Foundation for Cardiac Surgery Development in Zabrze has been implementing research on the artificial heart. In 1995, an artificial ventricle, POLVAD, was implanted to a patient, and in 1998, the prototype of a clinical controller, POLPDU-401, was created. A further development of the studies on an implantable artificial heart requires an integrated approach and an application of advanced methods of materials sciences in order to develop new materials suitable for the contact with blood, as well as to apply a multilateral biomedical diagnostics in hydrodynamic conditions. The estimation of the cell–material interaction plays an important role in the biomaterial design. An analysis of the influence of the carbon content in titanium nitride on the biological and biophysical properties of biomaterial coatings was studied. The cell-material reactions were considered in dynamic and static conditions. Three groups of materials were under examinations – titanium nitride (TiN), as well as titanium carbonitride with a low and high carbon content – of which the best properties were observed for TiN. We found a strong influence of the stoichiometry of TiN (atomic ratio of Ti/N) on the biocompatibility. A non-stoichiometric TiN could have a negative influence on the surrounding tissue.
    Źródło:
    Bulletin of the Polish Academy of Sciences. Technical Sciences; 2010, 58, 2; 329-335
    0239-7528
    Pojawia się w:
    Bulletin of the Polish Academy of Sciences. Technical Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of surface modification methods for ReligaHeart® cardiac support system
    Autorzy:
    Major, R.
    Kustosz, R.
    Trembecka-Wójciga, K.
    Lackner, J. M.
    Major, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/352605.pdf
    Data publikacji:
    2016
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    ReligaHeart® cardiac support system
    pneumatic heart
    blood-polymer barrier
    proangiogenic effect
    Opis:
    The work is a review of the methods of the surface modification performed by the authors dedicated for for cardiac support system. It presents the evolution of designing the surface dedicated to direct contact with blood. Initially thin and ultrathin coatings were developed. They were designed as a blood-polymer barrier. The pneumatic heart assist devices are made of a medical grade polyurethane. A major milestone was to create advanced ceramic thin films expressing the flexible effects deposited by physical techniques. Coatings have evolved. Another milestone was the surface reproducing the microenvironment to capture progenitor cells from the bloodstream. Thin coatings were prepared, using methods of ion been, controlled residual stresses were introduced. Wrinkles appeared without cracking. This enabled taking control over the process of cell differentiation. Alternatively, the tissue inspired structure resulted of the coating in the form of extracellular matrix. The outer surface was modified with synthetic materials. This enabled the effective proteins docking to induce cell growth, recreating the luminal side of the blood vessel. Coagulation processes have been slowed down. In addition, it was found pro-angiogenic effect.
    Źródło:
    Archives of Metallurgy and Materials; 2016, 61, 3; 1399-1404
    1733-3490
    Pojawia się w:
    Archives of Metallurgy and Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Migration channels produced by laser ablation for substrate endothelialization
    Autorzy:
    Major, R.
    Maksymow, K.
    Marczak, J.
    Lackner, J.
    Kot, M.
    Major, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/201285.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    inorganic coatings
    pulsed laser ablation
    tissue scaffold
    endothelial cells migration
    Opis:
    Seeding of cells on functional, biocompatible scaffolds is a crucial step in achievement the desired engineered tissue. In the present study, a pulsed laser modification onto inorganic substrate was made to promote endothelium cells migration and spread. Presented scaffolds were fabricated on carbon and titanium based coatings. Fabricated films provided very good mechanical properties together with a chemical stability preservation. The substrate modification consisted of grid-like template fabrication of micrometer size meshes. The microstructure analysis of laser traces revealed the grain size increase in the zone of laser beam interaction, which exerts an influence on a surface topography. Endothelium cells locomotion was observed within 10 day time period. As a result it was shown that the modified area enhanced cells adhesion with a preferred static behavior. The performed research work improved our understanding on the pulsed laser ablation process and template size influence on cells spatial arrangement. It constituted an important step towards fabrication of inorganic, biocompatible scaffolds for successful substrate endothelialization.
    Źródło:
    Bulletin of the Polish Academy of Sciences. Technical Sciences; 2012, 60, 2; 337-342
    0239-7528
    Pojawia się w:
    Bulletin of the Polish Academy of Sciences. Technical Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biomechanical properties of the thin PVD coatings defined by red blood cells
    Autorzy:
    Trembecka-Wojciga, K.
    Major, R.
    Lackner, J. M.
    Bruckert, F.
    Jasek, E.
    Major, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/201364.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    biomechanical properties
    thin PVD coatings
    red blood cells
    właściwości biomechaniczne
    cienkie powłoki PVD
    krwinki czerwone
    Opis:
    The measurement of the strength of bonds between biomaterials and cells is a major challenge in biotribology since it allows for the identification of different species in adhesion phenomena. Biomaterials, such as diamond-like carbon (DLC), titanium, and titanium nitride, seem to be good candidates for future blood-contact applications. These materials were deposited as thin films by the hybrid pulsed laser deposition (PLD) technique to examine the influence of such surfaces on cell behavior. The biomaterial examinations were performed in static conditions with red blood cells and then subjected to a dynamical test to observe the cell detachment kinetics. The tests revealed differences in behavior with respect to the applied coating material. The strongest cell-biomaterial interaction was observed for the carbon-based materials compared to the titanium and titanium nitride. Among many tests, a radial flow interaction analysis gives the opportunity to analyze cell adhesion to the applied material with the high accuracy. Analysis of concentrates helped to select materials for further dynamic tests on blood using an aortic flow simulator. In this case, the platelet adhesion to the surface and their degree of activation was analyzed. The quality of the selected coating was tested using a scratch test. The analyses of the microstructure were done using high resolution transmission electron microscopy. The phase composition and the residual stress were analyzed using X-ray diffraction methods.
    Źródło:
    Bulletin of the Polish Academy of Sciences. Technical Sciences; 2015, 63, 3; 697-705
    0239-7528
    Pojawia się w:
    Bulletin of the Polish Academy of Sciences. Technical Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Initial in vivo biocompatybility evaluation of biomaterials used in the new biomimetic heart valve
    Autorzy:
    Gonsior, M.
    Zawidlak-Węgrzyńska, B.
    Janiczak, K.
    Gonsior, D.
    Kustosz, R.
    Major, R.
    Lackner, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/283829.pdf
    Data publikacji:
    2018
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    biomaterials
    polyurethane
    biocompatibility
    Źródło:
    Engineering of Biomaterials; 2018, 21, 148; 81
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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