- Tytuł:
- Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model - a type II isobolographic analysis
- Autorzy:
-
Luszczki, J.J.
Wlaz, A.
Kondrat-Wrobel, M.W.
Pyrka, D.
Florek-Luszczki, M. - Powiązania:
- https://bibliotekanauki.pl/articles/3145.pdf
- Data publikacji:
- 2014
- Wydawca:
- Instytut Medycyny Wsi
- Tematy:
-
6 Hz psychomotor seizure model
antiepileptic drug
drug interaction
ethosuximide
levetiracetam
isobolographic analysis - Opis:
- The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in combination with ethosuximide in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. With type II isobolographic analysis, the combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05 and P<0.01, respectively) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. The combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 appear to be particularly favorable combinations exerting supra-additive interaction in the mouse 6 Hz psychomotor seizure model. Finally, it may be concluded that because of the synergistic interactions between levetiracetam and ethosuximide, the combination might be useful in clinical practice.
- Źródło:
-
Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395 - Pojawia się w:
- Journal of Pre-Clinical and Clinical Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł