Temat: biological synthesis - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Zasady Schiffa : wybrane syntezy, reakcje i aktywność biologiczna
Schiff bases : selected syntheses, reactions and biological activity
Autorzy:: Nowicka, A.
Liszkiewicz, H.
Nawrocka, W. P.
Powiązania:: https://bibliotekanauki.pl/articles/172082.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: zasada Schiffa
iminy
aktywność biologiczna
synteza
struktura
Schiff bases
imines
biological activity
synthesis
structure
Opis:: Schiff bases are compounds with a functional group that contains a carbon- -nitrogen double bond with the nitrogen atom connected to an aryl or alkyl group. Schiff bases are condensation products of primary amines with carbonyl compound. Several studies showed that the presence of a lone pair of electrons on the nitrogen atom of the azomethine determine biological and chemical properties of imines. Schiff bases are generally excellent chelating agents, because of the special properties of C=N bond. Their metal complexes have been widely studied because they possess anticancer in vitro and herbicidal applications. Imines also have biological importance. Schiff bases are common enzymatic intermediates where an amine reacts with an aldehyde or ketone of a cofactor or a substrate. Imines have been reported for their biological properties such as antibacterial (E. coli, S. aureus), antifungal (C. albicans) activities. A large number of different Schiff bases are active against a wide range of protozoan (T. gypseum, P. viticola).
Źródło:: Wiadomości Chemiczne; 2014, 68, 3-4; 187-209
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Syntezy, struktury i aktywność biologiczna pochodnych imidazo[4,5-b] pirydyny. Część 1
Synthesis, structures and biological activity of imidazo [4,5-b]pyridine derivatives. Part 1
Autorzy:: Liszkiewicz, H.
Nowicka, A.
Nawrocka, W. P.
Powiązania:: https://bibliotekanauki.pl/articles/171672.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: pochodne imidazo[4,5-b]pirydyny
aktywność biologiczna
synteza
struktura
imidazo[4,5-b]pyridine derivatives
biological activity
synthesis
structure
Opis:: This review presents most of the literature data about imidazo[4,5-b]pyridine derivatives and their biological activity. The main goal of this paper is to present various methods for the preparation of imidazo[4,5-b]pyridine analogues. There are some drugs, imidazo[4,5-b]pyridine derivatives, registered in the world, which exhibit diverse pharmacological activities. Noberastine [4] represent antihistaminic II generation drug with selective activity to H1 receptors. Tenatoprazole [5] is a novel proton pump inhibitor with a prolonged plasma half-life which possesses antiulcer activity. Sulmazole [3] is a new cardiotonic agent, an A1 adenosine receptor antagonist. Based on the review of the chemical literature, derivatives of imidazole[4,5-b] pyridine showed a multipharmacological effects. Presented compounds exhibit anticancer [14, 17, 19], antidepressant [44, 45], cardiotonic, anticoagulant [37] activities. Some of them can be used in the treatment of heart diseases [3]. There were also described derivatives of imidazo[4,5-b]pyridine with the potential use in the treatment of diabetes [48], hypertension and hyperlipidemia. Some chemical compounds which contain in their structure the imidazo[4,5-b]pyridine system inhibit neurodegeneration [34, 38] and can be used in the treatment of neurodegenerative disorders eg. Parkinson’s disease, Alzheimer’s disease or multiple sclerosis. In addition, some of the imidazo[4,5-b]pyridine possess antivirial [40–42], antimicrobial and cytotoxic activities.
Źródło:: Wiadomości Chemiczne; 2012, 66, 11-12; 1071-1095
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Syntezy, struktury i aktywność biologiczna pochodnych imidazo[4,5-b] pirydyny. Część II
Synthesis, structures and biological activity of imidazo[4,5-b]pyridine derivatives. Part 2
Autorzy:: Liszkiewicz, H.
Nowicka, A.
Nawrocka, W. P.
Powiązania:: https://bibliotekanauki.pl/articles/171764.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: pochodne imidazo[4,5-b]pirydyny
aktywność biologiczna
syntezy
struktury
imidazo[4,5-b]pyridine derivatives
biological activity
synthesis
structures
Opis:: The main goal of this article is to present selected syntheses, structures and a various biological activity of imidazo[4,5-b]pyridine derivatives. During the past 20 years the biological activity of imidazo[4,5-b]pyridine have been intensively studied. Based on the review of the chemical literature, it was shown that derivatives of imidazole[4,5-b]pyridine showed a multipharmacological effects such as antibacterial effect [20–22] and antituberculotic activity [25–33], nonsteroidal antiinflammatory activity [35–43] and analgesic [44, 45] effect. Among compounds of this class antagonists of angiotensin II receptors that exhibit hypotensive activity are also known [9–11]. Compounds containing imidazo[4,5-b]pyridine moiety can be synthesized from different substrates. The most useful starting compounds for the synthesis of imidazo[4,5-b]pyridine are derivatives of 2,3-diaminopyridine [1–3].
Źródło:: Wiadomości Chemiczne; 2013, 67, 3-4; 227-250
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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