Autor: Walkowiak, Jarosław - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Genotyp a funkcja zewnątrzwydzielnicza trzustki w mukowiscydozie
Autorzy:: Lisowska, Aleksandra
Biczysko, Maciej
Walkowiak, Jarosław
Powiązania:: https://bibliotekanauki.pl/articles/551981.pdf
Data publikacji:: 2011
Wydawca:: Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:: mukowiscydoza
genotyp
mutacje genu CFTR
funkcja zewnątrzwydzielnicza trzustki
Źródło:: Family Medicine & Primary Care Review; 2011, 2; 332-333
1734-3402
Pojawia się w:: Family Medicine & Primary Care Review
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Small intestine bacterial overgrowth is frequent in cystic fibrosis: combined hydrogen and methane measurements are required for its detection
Autorzy:: Lisowska, Aleksandra
Wójtowicz, Jerzy
Walkowiak, Jarosław
Powiązania:: https://bibliotekanauki.pl/articles/1040476.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cystic fibrosis
small intestine bacterial overgrowth
breath test
hydrogen
methane
Opis:: Introduction: Hydrogen breath test (BT) is commonly used as a diagnostic tool for the detection of small intestine bacterial overgrowth (SIBO). It was reported that colonic methane production is far more frequent in cystic fibrosis (CF) patients than in other subjects. Therefore, measuring exclusively hydrogen in the diagnostic breath test for diagnosing SIBO might be of limited value. We aimed to assess the usefulness of combined measurement of hydrogen and methane expiration for the diagnosis of SIBO in CF. Material and Methods: The study comprised 62 CF patients aged 5 to 18 years. Three-hundred-ninety subjects assessed due to gastrointestinal symptoms for the presence of SIBO served as a comparative group. In all subjects hydrogen/methane BT using glucose was performed. A positive BT was defined as fasting hydrogen ≥ 20 ppm or fasting methane ≥ 10 ppm or a rise of ≥ 12 ppm hydrogen or ≥ 6 ppm methane over baseline during the test. Results: In 23 (37.1%) CF patients and in 52 (13.3%) subjects from the comparative group abnormal BT results were found. In seven (11.3%) CF patients and 29 (7.4%) of the other subjects studied methane measurement allowed diagnosis of SIBO. Conclusions: Small intestine bacterial overgrowth is frequent in cystic fibrosis. For its detection in cystic fibrosis and other gastrointestinal patients, combined hydrogen and methane measurement instead of hydrogen breath test should be applied. Without the additional measurement of methane a significant percentage of SIBO will be missed.
Źródło:: Acta Biochimica Polonica; 2009, 56, 4; 631-634
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Normal levels of serum pancreatic enzymes in patients with progressive familial intrahepatic cholestasis type 2
Autorzy:: Walkowiak, Jaroslaw
Jankowska, Irena
Lisowska, Aleksandra
Biczysko, Maciej
Wierzbicka, Aldona
Pawłowska, Joanna
Powiązania:: https://bibliotekanauki.pl/articles/1042733.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: pancreatitis
pancreatic enzymes
lipase
progressive familial intrahepatic cholestasis type 2
elastase-1
Opis:: Introduction. High prevalence of elevated serum pancreatic enzymes in children with cholestasis with normal fecal elastase-1 concentrations has been documented. However, this state is related predominantly to biliary atresia. Therefore, we aimed to assess pancreatic damage by measuring serum pancreatic enzymes in patients with progressive familial intrahepatic cholestasis type 2 (PFIC type 2). Materials and methods. Twenty PFIC type 2 patients with normal serum bilirubin and bile acid concentrations were included in the study. Thirty pancreatic insufficient cystic fibrosis (PI-CF) patients, thirty patients with acute pancreatitis (AP) and thirty healthy subjects (HS) served for the purpose of comparison. In all subjects, serum lipase and elastase-1 levels were measured. Results. In all but one PFIC type 2 patients and all HS normal lipase activities were found. Serum elastase-1 concentrations were normal in all PFIC type 2 patients and HS. The enzyme levels were very similar in both groups studied. Lipase activities in PFIC type 2 patients were significantly higher than in PI-CF patients (p < 0.00001) and lower than in patients with AP (p < 0.00001). Serum elastase-1 levels in PFIC type 2 patients were significantly lower than in patients with AP (p < 0.00001) and not different from those in PI-CF patients. In conclusion. serum pancreatic enzymes in patients with PFIC type 2 are normal. No pancreatic damage in these patients could be detected.
Źródło:: Acta Biochimica Polonica; 2010, 57, 4; 573-575
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis
Autorzy:: Lisowska, Aleksandra
Kobelska-Dubiel, Natalia
Jankowska, Irena
Pawłowska, Joanna
Moczko, Jerzy
Walkowiak, Jarosław
Powiązania:: https://bibliotekanauki.pl/articles/1039343.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: small intestinal bacterial overgrowth
progressive familial intrahepatic cholestasis
hydrogen-methane breath test
Opis:: Background & Aims: To date, no studies concerning the presence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis were published. Based upon characteristic of progressive familial intrahepatic cholestasis one can expect the coexistence of small intestinal bacterial overgrowth. The aim of the study was to assess the incidence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis. Methods: 26 patients aged 8 to 25 years with progressive familial intrahepatic cholestasis were included in the study. Molecular analysis of ABCB11 gene was performed in the vast majority of patients. In all patients Z-score for body weight and height, biochemical tests (bilirubin, bile acid concentration, fecal fat excretion) were assessed. In all patients hydrogen-methane breath test was performed. Results: On the basis of first hydrogen-methane breath test, diagnosis of small intestinal bacterial overgrowth was confirmed in 9 patients (35%), 5 patients (19%) had borderline results. The second breath test was performed in 10 patients: in 3 patients results were still positive and 2 patients had a borderline result. The third breath test was conducted in 2 patients and positive results were still observed. Statistical analysis did not reveal any significant correlations between clinical, biochemical and therapeutic parameters in patients with progressive familial intrahepatic cholestasis and coexistence of small intestinal bacterial overgrowth. Conclusions: Our results suggest that small intestinal bacterial overgrowth is frequent in patients with progressive familial intrahepatic cholestasis. Moreover, it seems that this condition has the tendency to persist or recur, despite the treatment.
Źródło:: Acta Biochimica Polonica; 2014, 61, 1; 103-107
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Antibiotic therapy and fat digestion and absorption in cystic fibrosis
Autorzy:: Lisowska, Aleksandra
Pogorzelski, Andrzej
Oracz, Grzegorz
Skorupa, Wojciech
Cofta, Szczepan
Szydłowski, Jarosław
Socha, Jerzy
Walkowiak, Jarosław
Powiązania:: https://bibliotekanauki.pl/articles/1039883.pdf
Data publikacji:: 2011
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: stable isotope breath test
malabsorption
antibiotic therapy
cystic fibrosis
Opis:: Antibiotic therapy in the cystic fibrosis (CF) mouse model has been shown to result in reduced bacterial load of the intestine and significant body mass gain. The effect was suggested to be linked to the improvement of intestinal digestion and absorption. Therefore, we aimed to assess the influence of routinely applied antibiotic therapy in CF patients on fat assimilation. Twenty-four CF patients aged 6 to 30 years entered the study. Inclusion criteria comprised confirmed exocrine pancreatic insufficiency and bronchopulmonary exacerbation demanding antibiotic therapy. Exclusion criteria comprised: antibiotic therapy six weeks prior to the test, liver cirrhosis, diabetes mellitus, oxygen dependency, the use of systemic corticosteroids. In all enrolled CF subjects, 13C-labelled mixed triglyceride breath test (13C MTG-BT) was performed to assess lipid digestion and absorption, before and after antibiotic therapy. Sixteen subjects were treated intravenously with ceftazidime and amikacin, eight patients orally with ciprofloxacin. Cumulative percentage dose recovery (CPDR) was considered to reflect digestion and absorption of lipids. The values are expressed as means (medians). The values of CPDR before and after antibiotic therapy did not differ in the whole studied group [4.6(3.3) % vs. 5.7(5.3) %, p = 0.100] as well as in the subgroup receiving them intravenously [4.6(3.2) % vs. 5.7(5.3) %, p = 0.327] or in that with oral drug administration [4.6(3.4) % vs. 5.7(5.4) %, p = 0.167]. In conclusion, antibiotic therapy applied routinely in the course of pulmonary exacerbation in CF patients does not seem to result in an improvement of fat digestion and absorption.
Źródło:: Acta Biochimica Polonica; 2011, 58, 3; 345-347
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Niedobór witaminy K u niemowląt chorych na mukowiscydozę
Autorzy:: Krzyżanowska, Patrycja
Lisowska, Aleksandra
Woś, Halina
Trawińska-Bartnicka, Maria
Bober, Lyudmyla
Rohovyk, Nataliya
Rachel, Marta
Walkowiak, Jarosław
Powiązania:: https://bibliotekanauki.pl/articles/552145.pdf
Data publikacji:: 2011
Wydawca:: Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:: mukowiscydoza, witamina K
niekarboksylowana protrombina
Źródło:: Family Medicine & Primary Care Review; 2011, 2; 171-173
1734-3402
Pojawia się w:: Family Medicine & Primary Care Review
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Single dose of green tea extract decreases lipid digestion and absorption from a test meal in humans
Autorzy:: Walkowiak, Jarosław
Bajerska, Joanna
Kargulewicz, Angelika
Lisowska, Aleksandra
Siedlerski, Gwidon
Szczapa, Tomasz
Kobelska-Dubiel, Natalia
Grzymisławski, Marian
Powiązania:: https://bibliotekanauki.pl/articles/1039556.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: green tea
digestion
absorption
mixed triglyceride breath test
Opis:: Background & Aims: Green tea is known worldwide for its high content of polyphenolic compounds and multifactorial beneficial effects on human health. The role of green tea as an inhibitor of lipid hydrolysis is widely discussed. The aim of the study was to assess the influence of green tea extract on lipid digestion and absorption. Methods: The study comprised 32 healthy volunteers aged 23 to 30 years with normal exocrine pancreatic function. In all subjects 13C-labelled mixed triglyceride breath test was performed twice with and without green tea extract ingestion. Cumulative percentage dose recovery was considered to reflect digestion and absorption of lipids. Values are expressed as medians and 1st-3rd quartile distribution. Results: In all subjects, cumulative percentage dose recovery values were normal in a placebo test (36.8% <30.1-43.3%>). These results were significantly higher (p=0.021) than those obtained in green tea extract test (28.8% <23.1-37.2%>). Results of six tests with GTE were abnormal. Conclusions: Single dose of green tea extract taken with a test meal decreases lipid digestion and absorption in humans.
Źródło:: Acta Biochimica Polonica; 2013, 60, 3; 481-483
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Adult-type hypolactasia and lactose malabsorption in Poland
Autorzy:: Mądry, Edyta
Lisowska, Aleksandra
Kwiecień, Jarosław
Marciniak, Ryszard
Korzon-Burakowska, Anna
Drzymała-Czyż, Sławomira
Mojs, Ewa
Walkowiak, Jarosław
Powiązania:: https://bibliotekanauki.pl/articles/1042735.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: lactose malabsorption
hypolactasia
genetic predisposition
lactose intolerance
Opis:: Background: The available data on the incidence of lactose malabsorption are contradictory. Potential bias in random selection is a major drawback of studies performed to-date. Moreover, molecular analysis of polymorphism -13910 C>T upstream of the lactase (LCT) gene (NM_005915.4:c.1917+326C>T; rs4988235) has not been reported in those studies. Therefore, in this study we aimed to assess genetic predisposition and clinical manifestation of adult-type hypolactasia (ATH). Patients and methods: In two-hundred randomly chosen healthy subjects (HS) aged from 18 to 20 years, the presence of -13910 C>T polymorphic variants upstream of the LCT gene was assessed. In a subgroup of subjects with genotype predisposing to ATH, hydrogen-methane breath test (BT) with lactose loading was conducted to determine the current state of lactase activity. In addition, clinical symptoms typical for lactose malabsorption were assessed using the questionnaire method. Results: Sixty-three out of 200 (31.5 %) HS had -13910 C/C genotype. Thus, genetically determined lactase persistence is expected in the remaining 137 (68.5 %) subjects. Thirteen out of 53 (24.5 %) HS having -13910 C/C genotype were proved to be lactose intolerant. Recalculating the data for the entire studied population it implies the incidence of lactose malabsorption in 7.7 % of subjects. Only three out of 13 (23.1 %) subjects with abnormal BT results, reported clinical symptoms related to lactose consumption. Conclusions: Significantly lower than previously reported incidence of clinically detectable lactose malabsorption in young healthy adults in Poland has been documented. The -13910 C/C genotype upstream of the LCT gene indicates a predisposition to ATH, but definitely does not define the current ability to tolerate lactose.
Źródło:: Acta Biochimica Polonica; 2010, 57, 4; 585-588
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Cystic fibrosis is a risk factor for celiac disease
Autorzy:: Walkowiak, Jarosław
Blask-Osipa, Anna
Lisowska, Aleksandra
Oralewska, Beata
Pogorzelski, Andrzej
Cichy, Wojciech
Sapiejka, Ewa
Kowalska, Mirosława
Korzon, Michał
Szaflarska-Popławska, Anna
Powiązania:: https://bibliotekanauki.pl/articles/1040437.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cystic fibrosis
celiac disease
antiendomysial antibodies
genetic predisposition
Opis:: Background: The coexistence of cystic fibrosis (CF) and celiac disease (CD) has been reported. To our knowledge there is no study directly comparing the incidence of CD in CF patients to that in the general population at the same time. There is no published data on genetic predisposition to CD in CF patients either. Therefore, in the present study we aimed to assess the genetic predisposition to CD and its incidence in CF patients comparing it to data from the general population. Patients and methods: Two hundred eighty-two CF patients were enrolled in the study. In 230 CF patients the genetic predisposition to CD (the presence of HLA-DQ2/ DQ8) was assessed. In all CF patients, serological screening for CD was conducted. In patients with positive antiendomysial antibodies (EMA) gastroduenoscopy was offered. Intestinal histology was classified according to modified Marsh criteria. The results of serological CD screening in 3235 Polish schoolchildren and HLA-DQ typing in 200 healthy subjects (HS) were used for comparison. Results: Positive EMA was found in 2.84% of the studied CF patients. The incidence of proven CD was 2.13%. The incidence of CD as well as positive serological screening were significantly more frequent in the CF group than in the general population. The frequency of CD-related HLA-DQ alleles in CF and HS did not differ. Conclusions: Genetic predisposition to celiac disease in cystic fibrosis patients is similar to that of the general population. However, our results suggest that cystic fibrosis is a risk factor for celiac disease development.
Źródło:: Acta Biochimica Polonica; 2010, 57, 1; 115-118
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki