Wszystkie pola: Denis, D. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Use of multi-planar reconstruction (MPR) and 3-dimentional (3D) CT to assess stability criteria in C2 vertebral fractures
Autorzy:: Krupski, W.
Kurys-Denis, E.
Matuszewski, L.
Plezia, B.
Powiązania:: https://bibliotekanauki.pl/articles/3690.pdf
Data publikacji:: 2007
Wydawca:: Instytut Medycyny Wsi
Źródło:: Journal of Pre-Clinical and Clinical Research; 2007, 01, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: PDGF-BB homodimer serum level – a good indicator of the severity of alcoholic liver cirrhosis
Autorzy:: Kurys-Denis, E.
Prystupa, A.
Luchowska-Kocot, D.
Krupski, W.
Bis-Wencel, H.
Panasiuk, L.
Powiązania:: https://bibliotekanauki.pl/articles/2085441.pdf
Data publikacji:: 2020
Wydawca:: Instytut Medycyny Wsi
Tematy:: alcohol
liver cirrhosis
Child-Pugh score
platelet derived growth factor AA
platelet growth factor AB
platelet derived
growth factor BB
Opis:: Introduction. Liver cirrhosis is a chronic disease in which progressive fibrosis is noted. This process leads to changed architectonics of the liver parenchyma and the appearance of regenerative nodules, all of which are caused by pathological activation of the hepatic stellate cells. This process is enhanced on a molecular level by many cytokines, with platelet-derived growth factors (PDGFs) playing the key role. Objective. The aim of the study was to assess serum concentrations of PDGFs active biodymers (PDGF-AA, PDGF-BB and PDGF-AB) in patients with alcoholic liver cirrhosis, and to correlate them with the stage of disease. Materials and method. 64 patients with alcoholic cirrhosis and a control group of 16 healthy individuals were analysed. Liver cirrhosis was determined based on clinical image, history of the patients’ alcohol consumption, laboratory findings and abdominal ultrasonography. The serum PDGF-AA, PDGF-BB and PDGF-AB concentrations were determined using ELISA kits. Results. Serum concentration of PDGF-AA and PDGF-BB homodimers increases in patients with alcoholic liver cirrhosis (p=0.034 and p<0.0001, respectively), unlike the serum concentration of PDGF-AB heterodimer (p>0.05). When the stage of the disease increases, the concentrations of PDGF-AA and PGFD-BB in blood also oncrease. Furthermore, the serum level of both PDGF-AA and PDGF-BB correlates significantly with the severity of alcoholic liver cirrhosis (measured by Pugh-Child’s scale), the correlation being stronger in the case of PDGF-BB levels than PDGF-AA (R=0.28; p=0.027 and R=0.26; p=0.038, respectively). Conclusions. The plasma levels of PDGF-AA and -BB may be indicators of alcohol-induced liver fibrosis process, and might be considered as future possible treatment targets, with PDGF-BB levels being an even better indicator than PDGF-AA levels.
Źródło:: Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 80-85
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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