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    Wyświetlanie 1-3 z 3
    Tytuł:
    Functional neuromarkers for neuropsychology
    Autorzy:
    Kropotov, Juri D
    Powiązania:
    https://bibliotekanauki.pl/articles/2137701.pdf
    Data publikacji:
    2018-03-19
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    neuroimaging
    quantitative EEG
    event related de/synchronization
    event-related potentials
    Opis:
    This article is written to commemorate the 40th year of the scientific career of Professor Maria Pąchalska, Head of the Department of Neuropsychology and Neurorehabilitation at Krakow University, President of the Polish Neuropsychological Society, and the Editor-in-chief of Acta Neuropsychologica, with whom I have been collaborating for over ten years. The subject matter of our work includes the introduction of HBI methodology to clinics and the search for neuromarkers in particular disease entities. What is the new methodology we are talking about? In general, we think of a biomarker (or biological marker) as a characteristic that can be objectively measured and evaluated as an index of normal or pathological biological processes. For disorders of the central nervous system, biomarkers can be classified as clinical, neuroimaging, biochemical or genetic, according to the type of information they provide. Expectations for the development of biomarkers are high, since they could lead to a significant improvement in diagnosing and possibly preventing neurological and psychiatric diseases. Neuroimaging is an array of neuroscience methods that include the techniques of magnetic resonance imaging (MRI), functional MRI (fMRI), and PET (positron emission tomography), as well as Electroencephalogram (EEG) and Magnetoencephalogram (MEG) techniques, such as quantitative EEG (QEEG), event related de/synchronization (ERD/ERS) and event-related potentials (ERPs).
    Źródło:
    Acta Neuropsychologica; 2018, 16(1); 1-7
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    FUNCTIONAL NEUROMARKERS OF POST-TRAUMATIC STRESS DISORDER (PTSD) IN A MAJOR ISCHEMIC STROKE SURVIVOR AFTER CAROTID ENDARTERECTOMY (CEA) REVASCULARIZATION
    Autorzy:
    Trystuła, Mariusz
    Góral-Półrola, Jolanta
    Kropotov, Juri D
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/2137757.pdf
    Data publikacji:
    2018-12-20
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    Event-Related Potentials (ERPs)
    cued GO/NOGO task
    information processing
    functional neuromarkers
    Opis:
    The aim of this study was to test the hypothesis of developing Post-Traumatic Stress Disorder (PTSD) in a major right-hemisphere ischemic brain stroke survivor half a year after CEA revascularization, with the use of Event Related Potentials (ERPs). He was in a serious condition and had limited consciousness. Therefore, the doctor informed the patient's wife about the possibility of sudden death. The patient heard this information and remembered it, which was one of the main causes of the development of PTSD. On the basis of previous research amplitudes of P3 ERP, components elicited in the cued GO/NOGO tasks have been chosen as the candidate for PTSD neuromarkers . A 44-year-old patient had a major ischemic brain stroke while sizeable atherosclerotic plaque causing critical stenosis of the internal carotid artery in Angio-CT was dioscovered. The patient was urgently operated on using CEA. After the operation he had the opportunity to see the removed plaque which had been the cause of his stroke. Despite the positive postoperative recovery, half a year later, the patient began to complain of flashbacks, anxiety, trouble in falling and staying asleep, difficulty in concentration, a loss of interest. For the diagnosis of PTSD we used Checklist Specific for a stressor (PCL-S). Additionally we used Checklist according to the Diagnostic Statistical Manual-5 (DSM-5) classification, and the patient met the PTSD criteria. The cognitive profile of the patient was measured with the use of the Wechsler Memory Test – III (WMS-III). Subsequently, the patient participated in the cued GO/NOGO task (Kropotov, 2009) with a recording 19-channel EEG. The P3 GO and NOGO waves in this task were found to be significantly smaller at p
    Źródło:
    Acta Neuropsychologica; 2018, 16(4); 417-429
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    FUNCTIONAL NEUROMARKERS OF COGNITIVE IMPAIRMENT IN VASCULAR DEMENTIA: A CASE STUDY
    Autorzy:
    Supińska, Marzena
    Górla-Półrola, Jolanta
    Cielebąk, Ksenia
    Herman-Sucharska, Izabela
    Kropotov, Juri D
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/2137937.pdf
    Data publikacji:
    2020-07-02
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    Cognitive impairment
    Quantitative Electro- Encephalogram (QEEG)
    Event-Related Potentials (ERPs)
    cued GO/NOGO task
    Opis:
    Early diagnosis and monitoring of disease progression in patients with Vascular Dementia (VaD) have become vital in clinical practice, as disease modifying treatments for VaD become available. The goal of our research was to study cognitive impairment in a patient at an early stage of VaD. We evaluated latencies of the P3 GO and NOGO components of event-related potentials (ERPs), elicited in cued GO/NOGO tasks, as potential neuromarkers of cognitive im- pairment, as suggested by previous research. The patient, a right-handed, 53-year-old male with a college edu- cation, suffered a transient ischemic attack (TIA) in 2011. During this attack, which lasted for a few minutes, he was confused and had trouble speaking, trouble seeing in both eyes, difficulty walking, problems with balance and coordination, and strange behavior. Se - ven years later, in 2018, he was assessed using the HBI methodol- ogy, which consisted of recording (1) a 19-channel EEG in resting state (with eyes open and eyes closed), and (2) a cued GO/NOGO task, and then comparing the results with EEG spectra and Event- Related Potentials (ERPs) data from normative and patient data - bases. The patient died in 2019. Post-mortem studies confirmed cortical microhaemorrhages neuropathological criteria for VaD. We did not found deposits of hyperphosphorylated tau (HPτ) and Aβ, which fulfil the neuropathological criteria for AD. The parietal-temporal-occipital EEG power was significantly higher in all conditions in this subject in comparison to healthy controls, indicating idling of the corresponding areas. The amplitude and la- tency of the P3 GO wave were found to be intact in the subject, in- dicating normal posterior cortical functioning in the cognitive task. The latency of the P3 GO wave was found to be significantly higher in the subject, indicating impairment of engagement operations. In a GO/NOGO task, ERPs provide a useful tool for assessment of brain functioning in clinical settings.
    Źródło:
    Acta Neuropsychologica; 2020, 18(3); 313-325
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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