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    Wyświetlanie 1-6 z 6
    Tytuł:
    [sprawozdanie] Konferencja naukowa Linguistics beyond and within – the outskirts of the regular, Lublin, 18–19 października 2017 roku
    Autorzy:
    Król, Magdalena
    Pilch, Krystian
    Powiązania:
    https://bibliotekanauki.pl/articles/475696.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Instytut Języka Polskiego PAN
    Źródło:
    Socjolingwistyka; 2018, 32; 303-307
    0208-6808
    Pojawia się w:
    Socjolingwistyka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sorption of oil products on the synthetic zeolite granules
    Autorzy:
    Król, Magdalena
    Rożek, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/127613.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Mineralogiczne
    Tematy:
    sorbent
    adsorption
    oil pollution
    zeolite Na-P1
    expanded glass
    Opis:
    In this work, lightweight granules of zeolite Na-P1 based on expanded glass aggregates were synthesized for the application in oil products’ sorption. The sorption of gasoline, diesel and silicone oil tests were also conducted for raw expanded glass, zeolite A, clinoptilolite and mineral sorbent available at a fuel station. All sorbents were also characterized in terms of the phase composition (X-ray diffraction) and structure (infrared spectroscopy). The zeolite Na-P1 granules achieved the highest values of sorption capacities (1.8, 2.1 and 2.6 g/g, respectively), which makes them promising materials for oils’ removal.
    Źródło:
    Mineralogia; 2020, 51, 1; 1-7
    1899-8291
    1899-8526
    Pojawia się w:
    Mineralogia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Plany ścieżki muzealnej Uniwersytetu Medycznego we Wrocławiu
    Plans for the museum path of the Medical University in Wrocław
    Autorzy:
    Pluta, Dominika
    Król, Magdalena
    Dobosz, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/2171584.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
    Tematy:
    muzea medyczne
    ścieżka muzealna
    Uniwersytet Medyczny Wrocław
    medical museums
    museum path
    Wrocław Medical University
    Opis:
    People have always been interested in discovering their past and seeking answers to their existential questions. Therefore institutions like museums, which collect exhibits related to the history and development of humans, have been known since antiquity. However, museology today has changed and is no longer confined to establishments related to popular fields like painting, sculpture and archaeology. Nowadays, there are also museums dedicated to medical sciences, which present the history of humanity in the sphere of its biological development. The Medical University in Wrocław can boast of several such establishments, although so far they have been treated as separate institutions. For this reason, the idea was created to combine them all into a single museum route, and to make it available to a broader visitor base. Thanks to this, people can view items from old and modern medicine practice located in many different sites, allowing them to deepen their knowledge and expand their interests. To make it easier for visitors to navigate through such a diverse complex, a special museum path has been created, along with a description of each location.
    Źródło:
    Opuscula Musealia; 2019, 26; 183-190
    0239-9989
    2084-3852
    Pojawia się w:
    Opuscula Musealia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Developmental toxicity of N-methylaniline following prenatal oral administration in rats
    Autorzy:
    Sitarek, Krystyna
    Gromadzińska, Jolanta
    Stetkiewicz, Jan
    Lutz, Piotr
    Król, Magdalena
    Domeradzka-Gajda, Katarzyna
    Wąsowicz, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/2177441.pdf
    Data publikacji:
    2016-02-10
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    rat
    N-methylaniline
    NMA
    developmental toxicity
    metHb
    toxicity
    Opis:
    Objectives The objective of the study was to assess prenatal toxicity of N-methylaniline (NMA) administered by gavage to pregnant female rats. Material and Methods Pregnant female rats were administered N-methylaniline in corn oil by gavage at daily doses of 0.8 mg/kg of body weight (b.w.), 4 mg/kg b.w., 20 mg/kg b.w. and 100 mg/kg b.w. from implantation (the 5th day post mating) to the day prior to the scheduled caesarean section (the 20th day of pregnancy). General behavior, body weight, food and water consumption, hematological, biochemical analyses and pathomorphological changes of the dams were recorded. Results All the females survived until the end of the study. The test substance was toxic to pregnant females, even at the lowest of the used doses, i.e., 0.8 mg/kg b.w./day. Lower weight gain during pregnancy and significantly higher NMA-dose-dependent absolute weight of the organs were noted in the exposed females. The females from the groups exposed at doses of 20 mg/kg b.w./day and 100 mg/kg b.w./day developed anemia and showed higher concentrations of free thyroxine (FT3) and free triiodothyronine (FT4) thyroid hormones. Total protein concentration exhibited an increase in all the exposed groups of females. In the prenatal toxicity study, administration of N-methylaniline throughout the embryonic and fetal periods produced embryotoxic effects at doses ranging 4–100 mg/kg b.w./day. Conclusions Considering the data obtained in this study, it is reasonable to assume that N-methylaniline administered orally to pregnant rats is toxic for mothers even at a low dose of 0.8 mg/kg b.w./day. However, this dose was not associated with any significant effects to their offspring. This prenatal exposure level may be considered as no-observed-adverse-effect level (NOAEL) for the progeny and a dose of 4 mg/kg b.w./day as the lowest-observed-adverse-effect level (LOAEL) for the progeny.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2016, 29, 3; 479-492
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The ESR1 and GPX1 gene expression level in human malignant and non-malignant breast tissues
    Autorzy:
    Król, Magdalena
    Galicki, Michał
    Grešner, Peter
    Wieczorek, Edyta
    Jabłońska, Ewa
    Reszka, Edyta
    Morawiec, Zbigniew
    Wąsowicz, Wojciech
    Gromadzińska, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1038523.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    estrogen receptor
    antioxidant enzymes
    gene expression
    breast cancer tissue
    Opis:
    Background: The aim of this study was to establish whether the gene expression of estrogen receptor alpha (encoded by ESR1) correlates with the expression of glutathione peroxidase 1 (encoded by GPX1) in the tumor and adjacent tumor-free breast tissue, and whether this correlation is affected by breast cancer. Such relationships may give further insights into breast cancer pathology with respect to the status of estrogen receptor. Methods: We used the quantitative real-time PCR technique to analyze differences in the expression levels of the ESR1 and GPX1 genes in paired malignant and non-malignant tissues from breast cancer patients. Results: ESR1 and GPX1 expression levels were found to be significantly down-regulated by 14.7% and 7.4% (respectively) in the tumorous breast tissue when compared to the non-malignant one. Down-regulation of these genes was independent of the tumor histopathology classification and clinicopathological factors, while the ESR1 mRNA level was reduced with increasing tumor grade (G1: 103% vs. G2: 85.8% vs. G3: 84.5%; p<0.05). In the non-malignant and malignant breast tissues, the expression levels of ESR1 and GPX1 were significantly correlated with each other (Rs=0.450 and Rs=0.360; respectively). Conclusion: Our data suggest that down-regulation of ESR1 and GPX1 was independent of clinicopathological factors. Down-regulation of ESR1 gene expression was enhanced by the development of the disease. Moreover, GPX1 and ESR1 gene expression was interdependent in the malignant breast tissue and further work is needed to determine the mechanism underlying this relationship.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 51-57
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prognostic value of lymphocyte-related systemic inflammatory biomarkers in triple negative breast cancer
    Wartość prognostyczna biomarkerów stanu zapalnego powiązanych z limfocytami w potrójnie ujemnym raku piersi
    Autorzy:
    Oraczewski, Rafał Karol
    Czerniawska-Meler, Małgorzata
    Korzeniewicz, Martyna
    Kade, Grzegorz
    Kozielec, Zygmunt
    Michalak, Maciej
    Król, Magdalena
    Zdaniukiewicz, Adam
    Bodnar, Lubomir
    Powiązania:
    https://bibliotekanauki.pl/articles/2159007.pdf
    Data publikacji:
    2022-06-29
    Wydawca:
    Medical Education
    Tematy:
    triple negative breast cancer
    neutrophil-to-lymphocyte ratio
    platelet-to-lymphocyte ratio
    the systemic immune inflammation index
    prognostic factor
    potrójnie ujemny rak piersi
    czynnik prognostyczny
    stosunek neutrofilów do limfocytów
    stosunek płytek do limfocytów
    wskaźnik ogólnoustrojowej reakcji immunologiczno-zapalnej
    Opis:
    The aim was to evaluate inflammatory biomarkers as prognostic factors in patients with triple negativbreast cancer. We have collected data from 143 patients and evaluated using Chi-Squared test, Wilcoxon–Mann–Whitney test and Cox regression. We found a relationship between high neutrophil- to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index and local advancement features: tumor (T3/T4) (P = 0.0001, P = 0.0198, P = 0.0001), positive regional lymph nodes (P = 0.0014, P = 0.0075, P = 0.0206). In the multivariate analysis metastatic disease, worse performance status and high NLR (Hazard ratio: 4.48 [2.05–9.80], P=0.0002; 2.23 [1.24–4.03], P=0.0010; 2.23 [1.24–4.03], P=0.0075) were adverse prognostic factors. High neutrophil-to-lymphocyte ratio with worse performance status turned out an adverse independent prognostic factors.
    Celem pracy było określenie wartości prognostycznej markerów stanu zapalnego u pacjentów z potrójnie ujemnym rakiem piersi. Zebrano dane dotyczące 143 chorych i oceniono używając testu chi-kwadrat, testu Wilcoxon–Mann–Whitney oraz regresji Coxa. Stwierdzono związek między wysokim poziomem stosunku neutrofilów do limfocytów, płytek do limfocytów, wskaźnikiem ogólnoustrojowej reakcji immunologiczno-zapalnej a miejscowym stopniem zaawansowania: guz (T3/T4) (P=0.0001, P=0.0198, P=0.0001), dodatnie regionalne węzły chłonne (P=0.0014, P=0.0075, P=0.0206). Wielowymiarowa analiza wykazała, że choroba rozsiana, gorszy stan sprawności oraz wysoki stosunek neutrofilów do limfocytów (Hazard ratio: 4.48 [2.05-9.80], P=0.0002; 2.23 [1.24-4.03], P=0.0010; 2.23 [1.24-4.03], P=0.0075) stanowią negatywne czynniki prognostyczne. Wysoki stosunek neutrofilów do limfocytów oraz gorszy stan sprawności stanowią niezależne negatywne czynniki prognostyczne.
    Źródło:
    OncoReview; 2022, 12, 2; 25-34
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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