Autor: Boguń, Maciej - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Influence of chitosan nonwoven fabric modification on its physicochemical and biological properties
Autorzy:: Dzierzkowska, Ewa
Ścisłowska-Czarnecka, Anna
Kolesińska, Beata
Boguń, Maciej
Stodolak-Zych, Ewa
Powiązania:: https://bibliotekanauki.pl/articles/284448.pdf
Data publikacji:: 2019
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: nonwoven fabric
modification
physicochemical properties
biological properties
Źródło:: Engineering of Biomaterials; 2019, 22, no.153; 108
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Synthetic extracellular matrix as a substrate for regenerative medicine
Autorzy:: Stodolak-Zych, Ewa
Menaszek, Elżbieta
Twardy, Aleksandra
Ścisłowska-Czarnecka, Anna
Boguń, Maciej
Kolesińska, Beata
Powiązania:: https://bibliotekanauki.pl/articles/285740.pdf
Data publikacji:: 2019
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: synthetic extracellular matrix
biomimetic
peptide
polysaccharides
laboratory model
Opis:: The work presents materials characteristics of fibrous polysaccharide substrates (calcium alginate, CA) modified with short peptides. Three types of synthesized peptides (hexapeptides) were composed of: cysteine (C) and tryptophan (W) named - (WWC)2or cysteine (C) and tyrosine (Y) named (YYC)2 or phenyloalanine (F) named 6F. The peptides size distribution (DLS method) showed that they agglomerated in an alcohol medium. These results were used to select a modification method of the fibrous substrates i.e. the peptides were deposited on the fibrous alginate substrate by the electrospraying technique. Using this method three kinds of polysaccharide- peptides systems were obtained i.e.: CA/(WWC)2, CA/(YYC)2CA/6F. As a reference material, the pure calcium alginate fibrous substrate was used. The results of modification with short peptides were evaluated via scanning electron microscopy (SEM): small aggregates were observed (40-100 nm) on the surface of fibers, and the fibers size remained the same after modification (11-12 μm). The size of aggregates depended on the kind of short peptide; the smaller (40 nm) aggregates were observed when the peptide had only aromatic chain (6F), the bigger (<100 nm) ones were observed when the peptide had heterocyclic rings in the chain (WWC and YYC). All materials were contacted with osteoblast-like cells (MG-63) to test biocompatibility (cells viability after 3 and 7 days) and the results proved showed higher viability in the polysaccharide-peptide system which increased with the time of observation. The durability of polysaccharide-peptide systems was tested using the enzymatic assay: collagenase confirmed the stability of materials. The progress of degradation rate was observed using infrared spectroscopy (FTIR-ATR) - the ratio on bands with C-O and C-OH increased after degradation under in vitro conditions.Results of the investigations on the fibrous substrates have confirmed that the system is a good model of an extracellular matrix (ECM) due to its chemical composition and microstructure which both have biomimetic characteristics. Thus, it may be used as a filling of bone defects supporting the regeneration of the damaged tissue. Additionally, it may also serve as the model research system of ECM.
Źródło:: Engineering of Biomaterials; 2019, 22, 152; 10-15
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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